2.7.7.15: choline-phosphate cytidylyltransferase

This is an abbreviated version!
For detailed information about choline-phosphate cytidylyltransferase, go to the full flat file.

Reaction

Synonyms

AtCCT1, CCT, CCT-alpha, CCT1, CCT2, CCTalpha, CCTalpha236, CCTbeta, CCTbeta2, CCTbeta3, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, choline-phosphate cytidylyltransferase A, choline-phosphate cytidylyltransferase-alpha, cholinephosphate cytidylyltransferase, CpCCT1, cpcT, CTalpha, CTbeta2, CTP-phosphocholine cytidylyltransferase, CTP:cholinephosphate cytidylyltransferase, CTP:phosphocholine cytidylyltransferase, CTP:phosphocholine cytidylyltransferase alpha, CTP:phosphocholine cytidylyltransferase alpha-isoform, CTP:phosphocholine cytidylyltransferase beta2, CTP:phosphocholine cytidylyltransferase beta3, CTP:phosphocholine cytidylyltransferase CCT, CTP:phosphocholine cytidylyltransferase-alpha, CTP:phosphocholine cytidylyltransferase-beta2, CTP:phosphocholine cytidylyltranspherase alpha, CTP:phosphorylcholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase CCT1, CTP:phosphorylcholine cytidylyltransferase CCT2, cytidine diphosphocholine pyrophosphorylase, cytidylyltransferase, cytidylyltransferase, choline phosphate, LmjF.18.1330, More, PCYT1A, PF3D7_1316600, PfCCT, phosphocholine cytidylyltransferase, phosphocholine cytidylyltransferase alpha, phosphorylcholine cytidylyltransferase, phosphorylcholine transferase, phosphorylcholine:CTP cytidylyltransferase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.15 choline-phosphate cytidylyltransferase

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Results	in table
36	Activating Compound
5722	AA Sequence
4	Application
1	CAS Registry Number
38	Cloned(Commentary)
1	Crystallization (Commentary)
164	Disease/ Diagnostics
9	Expression
36	General Information
6	General Stability
69	Inhibitors
4	Ki Value [mM]
106	KM Value [mM]
83	Localization
14	Metals/Ions
29	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
267	Organism
11	Pathway
38	PDB ID
11	pH Optimum
1	pH Range
1	pI Value
19	Posttranslational Modification
79	Protein Variants
33	Purification (Commentary)
4	Reaction
1	Reaction Type
102	Reference
104	Source Tissue
31	Specific Activity [micromol/min/mg]
10	Storage Stability
126	Substrates and Products (Substrate)
24	Subunits
117	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
9	Temperature Stability [°C]
14	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 2.7.7.15 - choline-phosphate cytidylyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

CTP + choline phosphate

diphosphate + CDP-choline

7 entries

CTP + choline phosphate

diphosphate + CDPcholine

9 entries

CTP + phosphocholine

diphosphate + CDP-choline

13 entries

additional information

?

-

8 entries

CTP + choline phosphate

diphosphate + CDP-choline

Arabidopsis thaliana

-

rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation

662451

-

-

?

CTP + choline phosphate

diphosphate + CDP-choline

Drosophila melanogaster

-

rate limiting enzyme for the synthesis of phosphatidylcholine

661238

-

-

?

CTP + choline phosphate

diphosphate + CDP-choline

Homo sapiens

-

rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis

662451

-

-

?

CTP + choline phosphate

diphosphate + CDP-choline

Meriones unguiculatus

-

rate limiting enzyme for the synthesis of phosphatidylcholine

662689

-

-

?

CTP + choline phosphate

diphosphate + CDP-choline

Mus musculus

-

rate limiting enzyme for the synthesis of phosphatidylcholine

660981, 662320

-

-

?

CTP + choline phosphate

diphosphate + CDP-choline

Mus musculus

-

rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility

662451

-

-

?

CTP + choline phosphate

diphosphate + CDP-choline

Rattus norvegicus

-

rate limiting enzyme for the synthesis of phosphatidylcholine

660981, 661213, 662237, 662320, 662364, 663437

-

-

?

CTP + choline phosphate

diphosphate + CDPcholine

Pisum sativum

-

rate limiting step in synthesis of phosphatidylcholine

642891

-

-

?

CTP + choline phosphate

diphosphate + CDPcholine

Rattus norvegicus

-

beta2 isoform specifically up-regulated during neuronal differentiation to increase phosphatidyl choline biosynthesis for growing neuritis

642913

-

-

?

CTP + choline phosphate

diphosphate + CDPcholine

Rattus norvegicus

-

rate limiting step in synthesis of phosphatidylcholine

642893

-

-

?

CTP + choline phosphate

diphosphate + CDPcholine

Rattus norvegicus

-

membrane binding segment has important role in cellular lipid metabolism

642916

-

-

?

CTP + choline phosphate

diphosphate + CDPcholine

Rattus norvegicus

-

catalyzes a major rate-limiting step in the biosynthesis of phosphocholine

642908, 642909

-

-

?

CTP + choline phosphate

diphosphate + CDPcholine

Ricinus communis

-

catalyzes a major rate-limiting step in the biosynthesis of phosphocholine

642901

-

-

?

CTP + choline phosphate

diphosphate + CDPcholine

Streptococcus pneumoniae

-

plays a role in the biosynthesis of the phosphocholine-derivatized cell wall constituents that are critical for cell separation and pathogenesis

642922

-

-

?

CTP + choline phosphate

diphosphate + CDPcholine

Streptococcus pneumoniae

-

biosynthesis of the choline containing cell wall antigens, teichoic acid and lipoteichoic acid

642925

-

-

?

CTP + choline phosphate

diphosphate + CDPcholine

Streptococcus pneumoniae R36A

-

biosynthesis of the choline containing cell wall antigens, teichoic acid and lipoteichoic acid

642925

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Arabidopsis thaliana

Q9ZV56

-

761501

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Craterostigma plantagineum

-

-

762177

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Cricetulus griseus

-

-

721712

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Drosophila melanogaster

-

-

721989

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Homo sapiens

-

-

721712

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Homo sapiens

P49585

-

761500, 761872

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Leishmania major

Q4QDQ6

-

762463

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Mus musculus

-

-

721989, 761981

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Plasmodium falciparum

P49587

-

762404

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Plasmodium falciparum

Q8IEE9

-

762455

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Rattus norvegicus

-

-

737438

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Rattus norvegicus

P19836

-

761489

-

-

?

CTP + phosphocholine

diphosphate + CDP-choline

Rattus norvegicus

Q9QZC4

-

761598

-

-

?

additional information

?

-

Mus musculus

-

key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine, hepatic phosphatidylcholine biosynthesis is an important regulator of plasma high density lipoprotein

693101

-

-

?

additional information

?

-

Rattus norvegicus

-

active lipoprotein form, i.e. H-form, is the membrane-associated form of the enzyme in adult lung

642905

-

-

?

additional information

?

-

Rattus norvegicus

-

comparison of lipid regulation of yeast and rat enzyme

642904

-

-

?

additional information

?

-

Rattus norvegicus

-

H-form is the active form of enzyme in cytoplasm

642902

-

-

?

additional information

?

-

Rattus norvegicus

-

change in relative distribution of H-form and L-form in cytosol may be important in the regulation of phosphatidylcholine synthesis

642902

-

-

?

additional information

?

-

Rattus norvegicus

-

active form of enzyme on the ER, enzyme in cytosol appears to be latent

642908

-

-

?

additional information

?

-

Rattus norvegicus

-

CTbeta2 facilitates neurite outgrowth and branching

693089

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

comparison of lipid regulation of yeast and rat enzyme

642904

-

-

?