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2.7.7.15: choline-phosphate cytidylyltransferase

This is an abbreviated version!
For detailed information about choline-phosphate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.15

Reaction

CTP
+
phosphocholine
=
diphosphate
 +
CDP-choline

Synonyms

AtCCT1, CCT, CCT-alpha, CCT1, CCT2, CCTalpha, CCTalpha236, CCTbeta, CCTbeta2, CCTbeta3, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, choline-phosphate cytidylyltransferase A, choline-phosphate cytidylyltransferase-alpha, cholinephosphate cytidylyltransferase, CpCCT1, cpcT, CTalpha, CTbeta2, CTP-phosphocholine cytidylyltransferase, CTP:cholinephosphate cytidylyltransferase, CTP:phosphocholine cytidylyltransferase, CTP:phosphocholine cytidylyltransferase alpha, CTP:phosphocholine cytidylyltransferase alpha-isoform, CTP:phosphocholine cytidylyltransferase beta2, CTP:phosphocholine cytidylyltransferase beta3, CTP:phosphocholine cytidylyltransferase CCT, CTP:phosphocholine cytidylyltransferase-alpha, CTP:phosphocholine cytidylyltransferase-beta2, CTP:phosphocholine cytidylyltranspherase alpha, CTP:phosphorylcholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase CCT1, CTP:phosphorylcholine cytidylyltransferase CCT2, cytidine diphosphocholine pyrophosphorylase, cytidylyltransferase, cytidylyltransferase, choline phosphate, LmjF.18.1330, More, PCYT1A, PF3D7_1316600, PfCCT, phosphocholine cytidylyltransferase, phosphocholine cytidylyltransferase alpha, phosphorylcholine cytidylyltransferase, phosphorylcholine transferase, phosphorylcholine:CTP cytidylyltransferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.15 choline-phosphate cytidylyltransferase

Cloned

Cloned on EC 2.7.7.15 - choline-phosphate cytidylyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
CCTbeta2 isoform
-
deletion construct 1-236: expressed in T.ni cell using a baculovirus expression system, expressed in Escherichia coli BL21
deletion mutant which is truncated after residue 236, called CCTalpha236
-
expressed as native and His-tag fusion protein in Sf9 insect cells, native protein expressed in Escherichia coli but expressed protein was found to be misfolded
-
expressed in A-549 cell
-
expressed in A-549 cells
-
expressed in an adenoviral system
-
expressed in CHO-58 cells
-
expressed in Escherichia coli
-
expressed in Escherichia coli Rosetta cells and expressed by baculovirus infection of Trichoplusia ni cells
-
expressed in High 5 cells
-
expressed in insect cells
-
expressed in mice
-
expressed in PC-12 cells
-
expressed in Sf9 cells and Schneider 2 cells
expression in COS-1 cells, which have very low endogenous CTP:phosphocholine cytidylyltransferase activity
expression in Escherichia coli
full length enzyme and various truncated enzymes expressed in transgenic mice
-
heterologous expression of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum rescues Chinese Hamster Ovary cells deficient in the Kennedy phosphatidylcholine biosynthesis pathway
His-tagged version expressed in Sf9 cell using a baculovirus exression system
isozyme CCTalpha is expressed in baculovirus-infected cells
native and mutant enzyme expressed as His-tag fusion proteins in COS-1 cells
-
overexpression of the CTP:phosphocholine cytidylyltransferase (AtCCT1) catalytic domain in Nicotiana benthamiana leaves increased phosphatidylcholine content, and sucrose nonfermenting 1-related protein kinase 1 (SnRK1) co-expression reduces this effect
wild-type and deletion mutants delta312-367, delta231-367 and delta257-367
-
wild-type and truncated form
-
wild-type and truncated forms
-