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2.7.7.15: choline-phosphate cytidylyltransferase

This is an abbreviated version!
For detailed information about choline-phosphate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.15

Reaction

CTP
+
phosphocholine
=
diphosphate
+
CDP-choline

Synonyms

AtCCT1, CCT, CCT-alpha, CCT1, CCT2, CCTalpha, CCTalpha236, CCTbeta, CCTbeta2, CCTbeta3, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, choline-phosphate cytidylyltransferase A, choline-phosphate cytidylyltransferase-alpha, cholinephosphate cytidylyltransferase, CpCCT1, cpcT, CTalpha, CTbeta2, CTP-phosphocholine cytidylyltransferase, CTP:cholinephosphate cytidylyltransferase, CTP:phosphocholine cytidylyltransferase, CTP:phosphocholine cytidylyltransferase alpha, CTP:phosphocholine cytidylyltransferase alpha-isoform, CTP:phosphocholine cytidylyltransferase beta2, CTP:phosphocholine cytidylyltransferase beta3, CTP:phosphocholine cytidylyltransferase CCT, CTP:phosphocholine cytidylyltransferase-alpha, CTP:phosphocholine cytidylyltransferase-beta2, CTP:phosphocholine cytidylyltranspherase alpha, CTP:phosphorylcholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase CCT1, CTP:phosphorylcholine cytidylyltransferase CCT2, cytidine diphosphocholine pyrophosphorylase, cytidylyltransferase, cytidylyltransferase, choline phosphate, LmjF.18.1330, More, PCYT1A, PF3D7_1316600, PfCCT, phosphocholine cytidylyltransferase, phosphocholine cytidylyltransferase alpha, phosphorylcholine cytidylyltransferase, phosphorylcholine transferase, phosphorylcholine:CTP cytidylyltransferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.15 choline-phosphate cytidylyltransferase

Activating Compound

Activating Compound on EC 2.7.7.15 - choline-phosphate cytidylyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
activator protein-1
-
potential regulator of CCTbeta2 expression in neuronal cells
-
conduritol-B-epoxide
diphosphatidylglycerol
-
dithiothreitol
-
20 mM
fatty acids
-
activity slightly enhanced by addition of saturated fatty acids, markedly increased by addition of unsaturated fatty acids regardless of chain length and number of double bonds
glucosylceramide
Lipids
-
phosphatidylcholine
6fold enhancement of activity at 0.025 mM
phosphatidylglycerol
phosphatidylinositol
-
retinoblastoma protein
-
regulates CTalpha expression by different mechanisms depending on the phase of the cell cycle, the regulation of CTalpha expression requires both the Sp1 and the retinoblastoma control elements
-
Sp1
-
Sp1 stimulates CTalpha transcription, and Sp1-mediated transcription is stimulated by the retinoblastoma protein
-
additional information
-