2.7.7.13: mannose-1-phosphate guanylyltransferase
This is an abbreviated version!
For detailed information about mannose-1-phosphate guanylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.13
-
2.7.7.13
-
asa
-
phosphomannomutase
-
l-ascorbic
-
limb-girdle
-
myasthenic
-
l-galactose
-
dystroglycanopathies
-
gmpase
-
gdp-l-galactose
-
mannose-containing
-
alpha-dystroglycan
-
l-galactono-1,4-lactone
-
smirnoff-wheeler
-
acerola
-
l-galactose-1-phosphate
-
drug development
-
synthesis
-
medicine
-
agriculture
- 2.7.7.13
- asa
- phosphomannomutase
-
l-ascorbic
-
limb-girdle
-
myasthenic
- l-galactose
- dystroglycanopathies
-
gmpase
- gdp-l-galactose
-
mannose-containing
- alpha-dystroglycan
- l-galactono-1,4-lactone
-
smirnoff-wheeler
- acerola
-
l-galactose-1-phosphate
- drug development
- synthesis
- medicine
- agriculture
Reaction
Synonyms
BceA, BceA(J) protein, BceAJ, CYT1, GDP-alpha-D-mannose pyrophosphorylase, GDP-D-mannose pyrophosphorylase, GDP-Man pyrophosphorylase, GDP-mannose pyrophosphorylase, GDP-mannose pyrophosphorylase B, GDP-ManPP, GDP-MP, GDPMan pyrophosphorylase, GMP, GMP3, GMPase, GMPBB, GMPP, GMPP1, GMPP2, GMPP3, GMPPB, GTP-alpha-D-Man-1-P guanylyltransferase, GTP-mannose 1-phosphate guanylyltransferase, GTP-mannose-1-phosphate guanylyltransferase, guanidine diphosphomannose pyrophosphorylase, guanidine diphosphomannose pyrophoyphorylase, guanosine 5'-diphosphate-mannose pyrophosphorylase, guanosine 5'-diphospho-D-mannose pyrophosphorylase, guanosine diphosphate mannose pyrophosphorylase, guanosine diphosphate mannose pyrophosphorylase B, guanosine diphosphate-mannose pyrophosphorylase, guanosine diphosphomannose pyrophosphorylase, guanosine triphosphate-mannose 1-phosphate guanylyltransferase, guanosine-diphospho-D-mannose pyrophosphorylase, guanylyltransferase, mannose 1-phosphate, LDBPK_230120, Man-1-PGTase, mannose 1-phosphate guanyltransferase, mannose 1-phosphate guanylyltransferase (guanosine triphosphate), mannose-1-phosphate guanyl transferase, mannose-1-phosphate guanyltransferase beta, mannose-1-phosphate guanylyltransferase, More, MPG, MPG transferase, multiple sugar-1-P NTase, NDP-sugar pyrophosphorylase, NSPase, Os01g0847200, Os03g0268400, OsVTC1-1, OsVTC1-3, OsVTC1-8, PFManC, PH0925, PH0925 protein, PIM-GMP, RfbM, VCT1-1, VCT1-3, VTC1, VTC1-1, VTC1-3
ECTree
2.7.7.13 mannose-1-phosphate guanylyltransferaseAdvanced search results
results (
results (Reference
top
Reference on EC 2.7.7.13 - mannose-1-phosphate guanylyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
May, T.B.; Shinabarger, D.; Boyd, A.; Chakrabarty, A.M.
Identification of amino acid residues involved in the activity of phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase. A bifunctional enzyme in the alginate biosynthetic pathway of Pseudomonas aeruginosa
J. Biol. Chem.
269
4872-4877
1994
Pseudomonas aeruginosa (P07874)
Shinabarger, D.; Berry, A.; May, T.B.; Rothmel, R.; Fialho, A.; Chakrabarty, A.M.
Purification and characterization of phosphomannose isomerase-guanosine diphospho-D-mannose pyrophosphorylase. A bifunctional enzyme in the alginate biosynthetic pathway of Pseudomonas aeruginosa
J. Biol. Chem.
266
2080-2088
1991
Pseudomonas aeruginosa (P07874), Pseudomonas aeruginosa
Elling, L.; Ritter, J.E.; Verseck, S.
Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose
Glycobiology
6
591-597
1996
Arthrobacter sp., Salmonella enterica, Sus scrofa
Preiss, J.; Wood, E.
Sugar nucleotide reactions in Arthrobacter. I. Guanosine diphosphate mannose pyrophosphorylase: purification and properties
J. Biol. Chem.
239
3119-3126
1964
Arthrobacter sp., Arthrobacter sp. NRRL B1973
Szumilo, T.; Drake, R.R.; York, J.L.; Elbein, A.D.
GDP-mannose pyrophosphorylase. Purification to homogeneity, properties, and utilization to prepare photoaffinity analogs
J. Biol. Chem.
268
17943-17950
1993
Sus scrofa
Smoot, J.W.; Serif, G.S.
Purification of GTP:alpha-D-mannose-1-phosphate guanyltransferase
Eur. J. Biochem.
148
83-87
1985
Sus scrofa
Hashimoto, H.; Sakakibara, A.; Yamasaki, M.; Yoda, K.
Saccharomyces cerevisiae VIG9 encodes GDP-mannose pyrophosphorylase, which is essential for protein glycosylation
J. Biol. Chem.
272
16308-16314
1997
Saccharomyces cerevisiae (P41940), Saccharomyces cerevisiae
Fey, S.; Elling, L.; Kragl, U.
The cofactor Mg2+ - a key switch for effective continuous enzymic production of GDP-mannose using recombinant GDP-mannose pyrophosphorylase
Carbohydr. Res.
305
475-481
1998
Salmonella enterica
-
Kruszewska, J.S.; Saloheimo, M.; Penttila, M.; Palamarczyk, G.
Isolation of a Trichoderma reesei cDNA encoding GTP: a-D-mannose-1-phosphate guanyltransferase involved in early steps of protein glycosylation
Curr. Genet.
33
445-450
1998
Trichoderma reesei (O74624), Trichoderma reesei
Ning, B.; Elbein, A.D.
Purification and properties of mycobacterial GDP-mannose pyrophosphorylase
Arch. Biochem. Biophys.
362
339-345
1999
Mycolicibacterium smegmatis
Ohta, A.; Chibana, H.; Arisawa, M.; Sudoh, M.
The VIG9 gene products from the human pathogenic fungi Candida albicans and Candida glabrata encode GDP-mannose pyrophosphorylase
Biochim. Biophys. Acta
1475
265-272
2000
Candida albicans (O93827), Candida albicans, [Candida] glabrata (Q9Y725), [Candida] glabrata
Ning, B.; Elbein, A.D.
Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase: evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins
Eur. J. Biochem.
267
6866-6874
2000
Sus scrofa
Watt, G.M.; Flitsch, S.L.; Fey, S.; Elling, L.; Kragl, U.
The preparation of deoxy derivatives of mannose-1-phosphate and their substrate specificity towards recombinant GDP-mannose pyrophosphorylase from Salmonella enterica, group B
Tetrahedron
11
621-628
2000
Salmonella enterica
-
Garami, A.; Ilg, T.
Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability
EMBO J.
20
3657-3666
2001
Leishmania mexicana
Wu, B.; Zhang, Y.; Zheng, R.; Guo, C.; Wang, P.G.
Bifunctional phosphomannose isomerase/GDP-D-mannose pyrophosphorylase is the point of control for GDP-D-mannose biosynthesis in Helicobacter pylori
FEBS Lett.
519
87-92
2002
Helicobacter pylori
Janik, A.; Sosnowska, M.; Kruszewska, J.; Krotkiewski, H.; Lehle, L.; Palamarczyk, G.
Overexpression of GDP-mannose pyrophosphorylase in Saccharomyces cerevisiae corrects defects in dolichol-linked saccharide formation and protein glycosylation
Biochim. Biophys. Acta
1621
22-30
2003
Saccharomyces cerevisiae (P41940), Saccharomyces cerevisiae
Zakrzewska, A.; Palamarczyk, G.; Krotkiewski, H.; Zdebska, E.; Saloheimo, M.; Penttila, M.; Kruszewska, J.S.
Overexpression of the gene encoding GTP:mannose-1-phosphate guanyltransferase, mpg1, increases cellular GDP-mannose levels and protein mannosylation in Trichoderma reesei
Appl. Environ. Microbiol.
69
4383-4389
2003
Trichoderma reesei (O74624)
Uccelletti, D.; Staneva, D.; Rufini, S.; Venkov, P.; Palleschi, C.
Enhanced secretion of heterologous proteins in Kluyveromyces lactis by overexpression of the GDP-mannose pyrophosphorylase, KlPsa1p
FEMS Yeast Res.
5
735-746
2005
Kluyveromyces lactis
Sacchetti, S.; Bartolucci, S.; Rossi, M.; Cannio, R.
Identification of a GDP-mannose pyrophosphorylase gene from Sulfolobus solfataricus
Gene
332
149-157
2004
Saccharolobus solfataricus, Saccharolobus solfataricus P2
Sousa, S.A.; Moreira, L.M.; Wopperer, J.; Eberl, L.; Sa-Correia, I.; Leitao, J.H.
The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities
Biochem. Biophys. Res. Commun.
353
200-206
2007
Burkholderia cepacia, Burkholderia cepacia (Q06XM8), Burkholderia cepacia IST408, Burkholderia cepacia IST408 (Q06XM8)
Dowdle, J.; Ishikawa, T.; Gatzek, S.; Rolinski, S.; Smirnoff, N.
Two genes in Arabidopsis thaliana encoding GDP-l-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability
Plant J.
52
673689
2007
Arabidopsis thaliana
Badejo, A.A.; Jeong, S.T.; Goto-Yamamoto, N.; Esaka, M.
Cloning and expression of GDP-d-mannose pyrophosphorylase gene and ascorbic acid content of acerola (Malpighia glabra L.) fruit at ripening stages
Plant Physiol. Biochem.
45
665-672
2007
Malpighia glabra
Sousa, S.A.; Moreira, L.M.; Leitao, J.H.
Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities
Appl. Microbiol. Biotechnol.
80
1015-1022
2008
Burkholderia cenocepacia (B4EMQ6)
Mizanur, R.M.; Pohl, N.L.B.
Phosphomannose isomerase/GDP-mannose pyrophosphorylase from Pyrococcus furiosus: a thermostable biocatalyst for the synthesis of guanidinediphosphate-activated and mannose-containing sugar nucleotides
Org. Biomol. Chem.
7
2135-2139
2009
Pyrococcus furiosus
Jiang, H.; Ouyang, H.; Zhou, H.; Jin, C.
GDP-mannose pyrophosphorylase is essential for cell wall integrity, morphogenesis and viability of Aspergillus fumigatus
Microbiology
154
2730-2739
2008
Aspergillus fumigatus (Q4U3E8), Aspergillus fumigatus, Aspergillus fumigatus Af293 (Q4U3E8)
Siddique, S.; Endres, S.; Atkins, J.M.; Szakasits, D.; Wieczorek, K.; Hofmann, J.; Blaukopf, C.; Urwin, P.E.; Tenhaken, R.; Grundler, F.M.; Kreil, D.P.; Bohlmann, H.
Myo-inositol oxygenase genes are involved in the development of syncytia induced by Heterodera schachtii in Arabidopsis roots
New Phytol.
184
457-472
2009
Arabidopsis thaliana (O22287), Arabidopsis thaliana (Q8H1Q7), Arabidopsis thaliana (Q9M2S0)
Asencion Diez, M.D.; Demonte, A.; Giacomelli, J.; Garay, S.; Rodrigues, D.; Hofmann, B.; Hecht, H.J.; Guerrero, S.A.; Iglesias, A.A.
Functional characterization of GDP-mannose pyrophosphorylase from Leptospira interrogans serovar Copenhageni
Arch. Microbiol.
192
103-114
2010
Leptospira interrogans serovar Copenhageni
Denton, H.; Fyffe, S.; Smith, T.K.
GDP-Mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei
Biochem. J.
425
603-614
2010
Trypanosoma brucei (B9WNA1), Trypanosoma brucei
Barth, C.; Gouzd, Z.A.; Steele, H.P.; Imperio, R.M.
A mutation in GDP-mannose pyrophosphorylase causes conditional hypersensitivity to ammonium, resulting in Arabidopsis root growth inhibition, altered ammonium metabolism, and hormone homeostasis
J. Exp. Bot.
61
379-394
2010
Arabidopsis thaliana
Qin, C.; Qian, W.; Wang, W.; Wu, Y.; Yu, C.; Jiang, X.; Wang, D.; Wu, P.
GDP-mannose pyrophosphorylase is a genetic determinant of ammonium sensitivity in Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
105
18308-18313
2008
Arabidopsis thaliana
Lackovic, K.; Parisot, J.P.; Sleebs, N.; Baell, J.B.; Debien, L.; Watson, K.G.; Curtis, J.M.; Handman, E.; Street, I.P.; Kedzierski, L.
Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library
Antimicrob. Agents Chemother.
54
1712-1719
2010
Leishmania major
Zou, L.; Zheng, R.B.; Lowary, T.L.
Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica
Beilstein J. Org. Chem.
8
1219-1226
2012
Salmonella enterica
Pelissier, M.C.; Lesley, S.A.; Kuhn, P.; Bourne, Y.
Structural insights into the catalytic mechanism of bacterial guanosine-diphospho-D-mannose pyrophosphorylase and its regulation by divalent ions
J. Biol. Chem.
285
27468-27476
2010
Thermotoga maritima (Q9X0C3), Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 (Q9X0C3)
Pomel, S.; Rodrigo, J.; Hendra, F.; Cave, C.; Loiseau, P.M.
In silico analysis of a therapeutic target in Leishmania infantum: the guanosine-diphospho-D-mannose pyrophosphorylase
Parasite
19
63-70
2012
Leishmania infantum (A4I048), Leishmania infantum
Kempinski, C.F.; Haffar, R.; Barth, C.
Toward the mechanism of NH4+ sensitivity mediated by Arabidopsis GDP-mannose pyrophosphorylase
Plant Cell Environ.
34
847-858
2011
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Kumar, R.; Mustafiz, A.; Sahoo, K.K.; Sharma, V.; Samanta, S.; Sopory, S.K.; Pareek, A.; Singla-Pareek, S.L.
Functional screening of cDNA library from a salt tolerant rice genotype Pokkali identifies mannose-1-phosphate guanyl transferase gene (OsMPG1) as a key member of salinity stress response
Plant Mol. Biol.
79
555-568
2012
Oryza sativa
Cronje, C.; George, G.M.; Fernie, A.R.; Bekker, J.; Kossmann, J.; Bauer, R.
Manipulation of L-ascorbic acid biosynthesis pathways in Solanum lycopersicum: elevated GDP-mannose pyrophosphorylase activity enhances L-ascorbate levels in red fruit
Planta
235
553-564
2012
Saccharomyces cerevisiae (P41940), Saccharomyces cerevisiae FY23 (P41940), Solanum lycopersicum
Li, L.; Liu, Y.; Wan, Y.; Li, Y.; Chen, X.; Zhao, W.; Wang, P.G.
Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives
Org. Lett.
15
5528-5530
2013
Pyrococcus furiosus
Akutsu, J.; Zhang, Z.; Morita, R.; Kawarabayasi, Y.
Identification and characterization of a thermostable bifunctional enzyme with phosphomannose isomerase and sugar-1-phosphate nucleotidylyltransferase activities from a hyperthermophilic archaeon, Pyrococcus horikoshii OT3
Extremophiles
19
1077-1085
2015
Pyrococcus horikoshii (O58649), Pyrococcus horikoshii DSM 12428 (O58649), Pyrococcus horikoshii ATCC 700860 (O58649)
Carss, K.J.; Stevens, E.; Foley, A.R.; Cirak, S.; Riemersma, M.; Torelli, S.; Hoischen, A.; Willer, T.; van Scherpenzeel, M.; Moore, S.A.; Messina, S.; Bertini, E.; Boennemann, C.G.; Abdenur, J.E.; Grosmann, C.M.; Kesari, A.; Punetha, J.; Quinlivan, R.; Waddell, L.B.; Young, H.K.; Wraige, E.; Yau, S.; Bro, L. et al.
Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of alpha-dystroglycan
Am. J. Hum. Genet.
93
29-41
2013
Danio rerio (Q6DBU5), Danio rerio, Homo sapiens (Q9Y5P6)
Daligaux, P.; Bernadat, G.; Tran, L.; Cave, C.; Loiseau, P.; Pomel, S.; Ha-Duong, T.
Comparative study of structural models of Leishmania donovani and human GDP-mannose pyrophosphorylases
Eur. J. Med. Chem.
107
109-118
2016
Leishmania donovani (E9BG32), Homo sapiens (Q9Y5P6), Leishmania donovani BPK282A1 (E9BG32)
Qin, H.; Deng, Z.; Zhang, C.; Wang, Y.; Wang, J.; Liu, H.; Zhang, Z.; Huang, R.; Zhang, Z.
Rice GDP-mannose pyrophosphorylase OsVTC1-1 and OsVTC1-3 play different roles in ascorbic acid synthesis
Plant Mol. Biol.
90
317-327
2016
Oryza sativa Japonica Group (Q6Z9A3), Oryza sativa Japonica Group (Q84JH5), Oryza sativa Japonica Group (Q941T9)
Zhang, C.; Ouyang, B.; Yang, C.; Zhang, X.; Liu, H.; Zhang, Y.; Zhang, J.; Li, H.; Ye, Z.
Reducing AsA leads to leaf lesion and defence response in knock-down of the AsA biosynthetic enzyme GDP-D-mannose pyrophosphorylase gene in tomato plant
PLoS ONE
8
e61987
2013
Solanum tuberosum, Solanum lycopersicum (Q54K39), Solanum lycopersicum
Carss, K.J.; Stevens, E.; Foley, A.R.; Cirak, S.; Riemersma, M.; Torelli, S.; Hoischen, A.; Willer, T.; van Scherpenzeel, M.; Moore, S.A.; Messina, S.; Bertini, E.; Boennemann, C.G.; Abdenur, J.E.; Grosmann, C.M.; Kesari, A.; Punetha, J.; Quinlivan, R.; Waddell, L.B.; Young, H.K.; Wraige, E.; Yau, S.; et, al.
Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of alpha-dystroglycan
Am. J. Hum. Genet.
93
29-41
2013
Homo sapiens (Q9Y5P6)
Qin, H.; Deng, Z.; Zhang, C.; Wang, Y.; Wang, J.; Liu, H.; Zhang, Z.; Huang, R.; Zhang, Z.
Rice GDP-mannose pyrophosphorylase OsVTC1-1 and OsVTC1-3 play different roles in ascorbic acid synthesis
Plant Mol. Biol.
90
317-327
2016
Oryza sativa Japonica Group (Q84JH5), Oryza sativa Japonica Group (Q941T9)
Zhang, C.; Ouyang, B.; Yang, C.; Zhang, X.; Liu, H.; Zhang, Y.; Zhang, J.; Li, H.; Ye, Z.
Reducing AsA leads to leaf lesion and defence response in knock-down of the AsA biosynthetic enzyme GDP-D-mannose pyrophosphorylase gene in tomato plant
PLoS ONE
8
e61987
2013
Solanum lycopersicum (Q6J1L7), Solanum lycopersicum
Sousa, S.A.; Moreira, L.M.; Wopperer, J.; Eberl, L.; Sa-Correira, I.; Leitao, J.H.
The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities
Biochem. Biophys. Res. Commun.
353
200-206
2007
Burkholderia cepacia (Q06XM8), Burkholderia cepacia, Burkholderia cepacia IST408 (Q06XM8), Burkholderia cepacia IST408
Badejo, A.A.; Jeong, S.T.; Goto-Yamamoto, N.; Esaka, M.
Cloning and expression of GDP-D-mannose pyrophosphorylase gene and ascorbic acid content of acerola (Malpighia glabra L.) fruit at ripening stages
Plant Physiol. Biochem.
45
665-672
2007
Malpighia glabra (A0EJL9), Malpighia glabra
Zhao, S.; Liu, L.
Expression and crystallographic studies of the Arabidopsis thaliana GDP-D-mannose pyrophosphorylase VTC1
Acta Crystallogr. Sect. F
72
795-798
2016
Arabidopsis thaliana (O22287), Arabidopsis thaliana
Zmuda, F.; Shepherd, S.; Ferguson, M.; Gray, D.; Torrie, L.; De Rycker, M.
Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment
Antimicrob. Agents Chemother.
63
e01082-19
2019
Trypanosoma cruzi (Q4CMK4), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q4CMK4)
Pomel, S.; Mao, W.; Ha-Duong, T.; Cave, C.; Loiseau, P.
GDP-mannose pyrophosphorylase A biologically validated target for drug development against leishmaniasis
Front. Cell. Infect. Microbiol.
9
186
2019
Homo sapiens, Leishmania donovani, Leishmania mexicana
html completed
