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2.7.7.13: mannose-1-phosphate guanylyltransferase

This is an abbreviated version!
For detailed information about mannose-1-phosphate guanylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.13

Reaction

GTP
+
alpha-D-mannose 1-phosphate
=
diphosphate
 +
GDP-mannose

Synonyms

BceA, BceA(J) protein, BceAJ, CYT1, GDP-alpha-D-mannose pyrophosphorylase, GDP-D-mannose pyrophosphorylase, GDP-Man pyrophosphorylase, GDP-mannose pyrophosphorylase, GDP-mannose pyrophosphorylase B, GDP-ManPP, GDP-MP, GDPMan pyrophosphorylase, GMP, GMP3, GMPase, GMPBB, GMPP, GMPP1, GMPP2, GMPP3, GMPPB, GTP-alpha-D-Man-1-P guanylyltransferase, GTP-mannose 1-phosphate guanylyltransferase, GTP-mannose-1-phosphate guanylyltransferase, guanidine diphosphomannose pyrophosphorylase, guanidine diphosphomannose pyrophoyphorylase, guanosine 5'-diphosphate-mannose pyrophosphorylase, guanosine 5'-diphospho-D-mannose pyrophosphorylase, guanosine diphosphate mannose pyrophosphorylase, guanosine diphosphate mannose pyrophosphorylase B, guanosine diphosphate-mannose pyrophosphorylase, guanosine diphosphomannose pyrophosphorylase, guanosine triphosphate-mannose 1-phosphate guanylyltransferase, guanosine-diphospho-D-mannose pyrophosphorylase, guanylyltransferase, mannose 1-phosphate, LDBPK_230120, Man-1-PGTase, mannose 1-phosphate guanyltransferase, mannose 1-phosphate guanylyltransferase (guanosine triphosphate), mannose-1-phosphate guanyl transferase, mannose-1-phosphate guanyltransferase beta, mannose-1-phosphate guanylyltransferase, More, MPG, MPG transferase, multiple sugar-1-P NTase, NDP-sugar pyrophosphorylase, NSPase, Os01g0847200, Os03g0268400, OsVTC1-1, OsVTC1-3, OsVTC1-8, PFManC, PH0925, PH0925 protein, PIM-GMP, RfbM, VCT1-1, VCT1-3, VTC1, VTC1-1, VTC1-3

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.13 mannose-1-phosphate guanylyltransferase

Inhibitors

Inhibitors on EC 2.7.7.13 - mannose-1-phosphate guanylyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4E)-4-[(6-chloro-1,3-benzodioxol-5-yl)methylidene]-1-(3,4-dimethylphenyl)pyrazolidine-3,5-dione
-
-
(4Z)-1-(4-fluorophenyl)-4-[(5-methyltetrahydrofuran-2-yl)methylidene]pyrazolidine-3,5-dione
-
-
2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methylbutanoic acid
-
2-(5-ethyl-1,3,4-thiadiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
-
-
2-methyl-9H-pyrido[2,3-b]indole
-
-
3-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)-1H-indole
-
-
3-(2-ethyl-5-methyl-2H-pyrrol-3-yl)-6-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
-
-
3-(azetidin-1-yl)-N-(imidazo[1,2-a]pyridin-3-ylmethyl)propan-1-amine
-
3-[2-(4-methoxyphenyl)ethyl]-2H-1,2,4-benzothiadiazine 1,1-dioxide
-
-
4-(4-benzylpiperazin-1-yl)-7-chloroquinoline
-
-
4-[3-(3-aminopyrrolidin-1-yl)propoxy]benzoic acid
-
4-[4-(4-tert-butylbenzyl)piperazin-1-yl]-7-chloroquinoline
-
-
4-[4-(biphenyl-4-ylmethyl)piperazin-1-yl]-7-chloroquinoline
-
-
4-[4-[(4-tert-butylphenyl)methyl]piperazin-1-yl]-7-chloroquinoline
5-(2-amino-1,3-thiazol-4-yl)-2-hydroxybenzyl acetate
-
5-methyl-2-(2-phenylethyl)-1H-benzimidazole
-
-
6-(1-ethyl-3-propyl-1H-pyrazol-5-yl)-3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
-
-
6-(2,4-dichlorophenyl)-3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
-
-
6-(2-chloro-6-fluorobenzyl)-3-(2-ethyl-5-methyl-2H-pyrrol-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
-
-
6-(2-chloro-6-fluorobenzyl)-3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
-
-
6-(4-chlorophenyl)-3-(2-methylbenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
-
-
6-(4-fluorophenyl)-3-(4-methoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
-
-
6-[[(4,6-dimethylpyrimidin-2-yl)sulfanyl]methyl]-3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
-
-
7-chloro-4-(4-methylpiperazin-1-yl)quinoline
-
-
7-methoxy-4-oxo-4H-thiochromene-3-carboxylic acid
-
-
8-(dimethylamino)-7-hydroxy-3-(1-phenyl-1H-pyrazol-4-yl)-4H-chromen-4-one
-
-
9-(3,4-dimethoxyphenyl)-2,3-dihydroimidazo[1,2-c]thieno[3,2-e]pyrimidine
-
-
ammonium sulfate
-
-
Cu2+
-
-
diphosphate
-
strong product inhibition
ethyl (2Z)-(hydroxyimino)(1H-tetrazol-5-yl)ethanoate
-
-
GDP
-
0.4 mM, 50% inhibition
GDP-6-deoyxmannose
-
GDP-glucose
GDP-mannose
glucose 1-phosphate
GMP
-
0.4 mM, 50% inhibition
Hg2+
-
-
mannose 1-phosphate
-
noncompetitive inhibition of GDP-glucose phosphorolysis
methyl 1-cyano-2-hydroxy-9,10-dimethoxy-4-oxo-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-3-carboxylate
-
-
miltefosine
tetrapropan-2-yl [5-(1-[2-[(quinolin-2-yl)methoxy]ethyl]-1H-1,2,3-triazol-4-yl)pent-1-yne-4,4-diyl]bis(phosphonate)
Zn2+
-
-
[4-(7-chloroquinolin-4-yl)piperazin-1-yl](4-methylphenyl)methanone
-
-
additional information
-