2.7.7.12: UDP-glucose-hexose-1-phosphate uridylyltransferase

This is an abbreviated version!
For detailed information about UDP-glucose-hexose-1-phosphate uridylyltransferase, go to the full flat file.

Reaction

Synonyms

galactose 1-phosphate uridylyltransferase, galactose-1-phosphate uridyl transferase, galactose-1-phosphate uridyltransferase, galactose-1-phosphate uridylyltransferase, galactose-1-phosphate:uridyltransferase, GALT, GALT enzyme, GalT1, GalT2, hexose 1-phosphate uridyltransferase, hexose 1-phosphate uridylyltransferase, hexose-1-phosphate uridylyltransferase, UDP-Glc-hexose-1-P uridylyltransferase, UDP-glucose-hexose-1-P uridylyltransferase, UDPGlc:Gal-1-P uridylyltransferase, UDPglucose-hexose-1-phosphate uridylyltransferase, UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase, uridine diphosphoglucose:alpha-D-galactose-1-phosphate uridilyltransferase, uridyl transferase, uridyltransferase, uridylylgalactose-1-P uridylyltransferase, uridylyltransferase, hexose 1-phosphate

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.12 UDP-glucose-hexose-1-phosphate uridylyltransferase

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Results	in table
12	Activating Compound
20418	AA Sequence
8	Application
1	CAS Registry Number
29	Cloned(Commentary)
8	Crystallization (Commentary)
188	Disease/ Diagnostics
27	General Information
11	General Stability
71	Inhibitors
16	kcat/KM [mM/s]
8	Ki Value [mM]
122	KM Value [mM]
40	Metals/Ions
28	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
113	Organism
7	Pathway
11	PDB ID
21	pH Optimum
3	pH Range
5	pH Stability
3	pI Value
117	Protein Variants
38	Purification (Commentary)
32	Reaction
1	Reaction Type
92	Reference
1	Renatured (Commentary)
29	Source Tissue
72	Specific Activity [micromol/min/mg]
13	Storage Stability
148	Substrates and Products (Substrate)
27	Subunits
74	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
5	Temperature Range [°C]
9	Temperature Stability [°C]
36	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.7.7.12 - UDP-glucose-hexose-1-phosphate uridylyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

2 entries

CDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + CDP-galactose

2 entries

TDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + TDP-galactose

3 entries

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

13 entries

UDP-alpha-D-glucose + N-acetyl-alpha-D-galactosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-galactosamine

2 entries

UDP-alpha-D-glucose + N-acetyl-alpha-D-glucosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-glucosamine

2 entries

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

3 entries

UDP-glucose + 2-methylimidazole

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

2 entries

UDP-glucose + 4-methylimidazole

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

2 entries

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

79 entries

UDP-glucose + D-galactose 1-phosphate

D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

703249

-

-

?

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

6 entries

uridine 5'-phospho-2,4,5-trimethylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2,4,5-trimethylimidazole

2 entries

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2-methylimidazole

2 entries

uridine 5'-phospho-3-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 3-methylimidazole

2 entries

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 4-methylimidazole

2 entries

uridine 5'-phospho-5-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 5-methylimidazole

2 entries

UTP + alpha-D-galactose 1-phosphate

diphosphate + UDP-alpha-D-galactose

Homo sapiens

-

-

722074

-

-

?

additional information

?

-

18 entries

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

Gracilaria changii

-

-

723038

-

-

r

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

Homo sapiens

P07902

-

737739

-

-

r

CDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + CDP-galactose

Bifidobacterium bifidum

-

no activity

642826

-

-

?

CDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + CDP-galactose

Bos taurus

-

low activity

642828

-

-

?

TDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + TDP-galactose

Bifidobacterium bifidum

-

reaction at 60% the rate of UDP-glucose

642826

-

-

r

TDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + TDP-galactose

Bos taurus

-

8.7% activity compared to UDP-glucose

642828

-

-

r

TDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + TDP-galactose

Escherichia coli

-

no activity

642823

-

-

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Bifidobacterium bifidum

M4M7K7, M4MCS2

-

737498

-

-

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Bifidobacterium bifidum PRL2010

M4M7K7, M4MCS2

-

737498

-

-

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Escherichia coli

-

-

722427

-

-

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Gracilaria changii

-

-

723038

-

-

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Gracilariopsis lemaneiformis

-

-

722471

-

-

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Homo sapiens

-

-

722427

-

-

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Homo sapiens

P07902

-

737739

-

-

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum

Q8ZXN7

-

721231

-

-

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum

Q8ZXN7

the enzyme is involved in galactose metabolism via the Leloir pathway

762352

-

-

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum

Q8ZXN7

binding of the glucose moiety of the substrate, but not the UDP moiety, gives rise to a large structural change around the active site

762352

-

-

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum ATCC 51768

Q8ZXN7

the enzyme is involved in galactose metabolism via the Leloir pathway

762352

-

-

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum ATCC 51768

Q8ZXN7

binding of the glucose moiety of the substrate, but not the UDP moiety, gives rise to a large structural change around the active site

762352

-

-

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum DSM 7523

Q8ZXN7

-

721231

-

-

r

UDP-alpha-D-glucose + N-acetyl-alpha-D-galactosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-galactosamine

Bifidobacterium bifidum

M4M7K7, M4MCS2

-

737498

-

-

?

UDP-alpha-D-glucose + N-acetyl-alpha-D-galactosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-galactosamine

Bifidobacterium bifidum PRL2010

M4M7K7, M4MCS2

-

737498

-

-

?

UDP-alpha-D-glucose + N-acetyl-alpha-D-glucosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-glucosamine

Bifidobacterium bifidum

M4M7K7, M4MCS2

-

737498

-

-

?

UDP-alpha-D-glucose + N-acetyl-alpha-D-glucosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-glucosamine

Bifidobacterium bifidum PRL2010

M4M7K7, M4MCS2

-

737498

-

-

?

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

Escherichia coli

-

stereochemistry: enzyme accepts (Rp)-UDP-alphaS-glucose converting it to (Rp)-UDP-alphaS-galactose, the overall retention of configuration arises from inversion in each of the two steps

642824

(Rp1)-UDP-alphaS-galactose, i.e. uridine 5'-(1-thiodiphosphate) galactose

642824

r

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

Escherichia coli

-

i.e. uridine 5'-(1-thiodiphosphate) glucose

642824

(Rp1)-UDP-alphaS-galactose, i.e. uridine 5'-(1-thiodiphosphate) galactose

642824

r

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

Escherichia coli

-

(Rp1)-UDP-alphaS-glucose

642824

(Rp1)-UDP-alphaS-galactose, i.e. uridine 5'-(1-thiodiphosphate) galactose

642824

r

UDP-glucose + 2-methylimidazole

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

kinetic study

642843

-

642843

r

UDP-glucose + 2-methylimidazole

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

mutant H166G, i.e. UDP-hexose synthase

642843

-

642843

r

UDP-glucose + 4-methylimidazole

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

kinetic study

642843

-

642843

r

UDP-glucose + 4-methylimidazole

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

mutant H166G, i.e. UDP-hexose synthase

642843

-

642843

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bifidobacterium bifidum

-

highly specific for the substrates

642826

-

642826

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bifidobacterium bifidum

-

involved in conversion of galactose into alpha-D-glucose 1-phosphate, Leloir pathway

642826

-

-

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bos taurus

-

-

642828

-

642828

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bos taurus

-

-

642829

-

642829

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bos taurus

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bos taurus

-

-

642835

-

642835

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bos taurus

-

important step in galactose metabolism

642828

-

-

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Capra hircus

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Cavia porcellus

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Cavia porcellus Hartley

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Chlorocebus aethiops

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Cucumis melo

-

-

642821

-

642821

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Cucumis melo

-

central enzyme in the classical Lelior pathway, but not in galactose metabolsim

642821

-

642821

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Equus caballus

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

-

642824

-

642824

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

-

642825

-

642825

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

-

642834

-

642834

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

-

642838

-

642838

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

-

642839

-

642839

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

-

642853

-

642853

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

-

642855

-

642855

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

-

642863

-

642863

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

P09148

-

642848

-

642848

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

P09148

-

642849

-

642849

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

P09148

-

642858

-

642858

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

P09148

-

642860

-

642860

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

stereochemistry: enzyme accepts (Rp)-UDP-alphaS-glucose converting it to (Rp)-UDP-alphaS-galactose, the overall retention of configuration arises from inversion in each of the two steps

642824

-

642824

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

formation of a covalent uridylyl-enzyme intermediate, i.e. UMP-enzyme

642824

-

642824

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

formation of a covalent uridylyl-enzyme intermediate, i.e. UMP-enzyme

642857

-

642857

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

formation of a covalent uridylyl-enzyme intermediate, i.e. UMP-enzyme

642863

-

642863

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

highly specific for the substrates

642823

-

642823

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

recombinant bifunctional chimeric fusion protein

2335

-

2335

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

2nd step of Leloir pathway

642838

-

642838

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

involved in conversion of galactose into alpha-D-glucose 1-phosphate, Leloir pathway

642857

-

642857

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Galdieria sulphuraria

-

highly specific for the substrates

642852

-

642852

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Galdieria sulphuraria

-

involved in conversion of galactose into alpha-D-glucose 1-phosphate, Leloir pathway

642852

-

-

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Glycine max

-

-

642821

-

642821

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642828

-

642828

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642830

-

642830

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642831

-

642831

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642832

-

642832

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642835

-

642835

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642836

-

642836

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642838

-

642838

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642840

-

642840

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642841

-

642841

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642842

-

642842

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642844

-

642844

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642851

-

642851

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642855

-

642855

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642856

-

642856

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642859

-

642859

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642861

-

642861

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642862

-

642862

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

-

642863

-

642863

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

2-step mechanism

642845

-

642845

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

galactosemia with altered activity of the follicle-stimulating hormone FSH

642840

-

642840

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

important step in galactose metabolism

642828

-

-

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

essential enzyme in galactose metabolism, deficiency causes genetic disorder galactosemia, e.g. mutant Duarte variant

642854

-

-

?

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

essential enzyme in galactose metabolism, deficiency causes genetic disorder galactosemia, e.g. mutant Duarte variant

642840

-

642840

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

essential enzyme in galactose metabolism, deficiency causes genetic disorder galactosemia, e.g. mutant Duarte variant

642841

-

642841

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

essential enzyme in galactose metabolism, deficiency causes genetic disorder galactosemia, e.g. mutant Duarte variant

642842, 642844

-

-

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

essential enzyme in galactose metabolism, deficiency causes genetic disorder galactosemia, e.g. mutant Duarte variant

642862

-

642862

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

2nd step of Leloir pathway

642831

-

-

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

2nd step of Leloir pathway

642838

-

642838

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

involved in the biosynthesis of follicle-stimulating hormone FSH

642840

-

642840

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Mus musculus

Q03249

-

642847

-

642847

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Mus musculus

Q03249

transcriptional regulation is complex and not directly induced by substrate levels

642847

-

-

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Oryctolagus cuniculus

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Ovis aries

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Rattus norvegicus

-

-

642833

-

642833

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Rattus norvegicus

-

-

642840

-

642840

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae

-

-

2309

-

2309

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae

-

-

642827

-

642827

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae

-

-

642838

-

642838

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae

-

2nd step of Leloir pathway

642838

-

642838

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae 106-3D

-

-

2309

-

2309

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae 106-3D

-

-

642827

-

642827

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

wild-type, 800fold reduced activity compared to normal reaction intermediate uridylyl-enzyme as substrate, pH-dependent

642863

-

642863

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

mutant H166A

642843

-

642843

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

mutant H166G, i.e. UDP-hexose synthase

642839

-

642839

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

mutant H166G, i.e. UDP-hexose synthase

642843

-

642843

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

equilibrium study and constants

642839

-

642839

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

equilibrium study and constants

642843

-

642843

r

uridine 5'-phospho-2,4,5-trimethylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2,4,5-trimethylimidazole

Escherichia coli

-

kinetic study

642843

-

642843

r

uridine 5'-phospho-2,4,5-trimethylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2,4,5-trimethylimidazole

Escherichia coli

-

mutant H166G, i.e. UDP-hexose synthase

642843

-

642843

r

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2-methylimidazole

Escherichia coli

-

kinetic study

642843

-

642843

r

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2-methylimidazole

Escherichia coli

-

mutant H166G, i.e. UDP-hexose synthase

642843

-

642843

r

uridine 5'-phospho-3-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 3-methylimidazole

Escherichia coli

-

kinetic study

642843

-

642843

r

uridine 5'-phospho-3-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 3-methylimidazole

Escherichia coli

-

mutant H166G, i.e. UDP-hexose synthase

642843

-

642843

r

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 4-methylimidazole

Escherichia coli

-

kinetic study

642843

-

642843

r

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 4-methylimidazole

Escherichia coli

-

mutant H166G, i.e. UDP-hexose synthase

642843

-

642843

r

uridine 5'-phospho-5-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 5-methylimidazole

Escherichia coli

-

kinetic study

642843

-

642843

r

uridine 5'-phospho-5-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 5-methylimidazole

Escherichia coli

-

mutant H166G, i.e. UDP-hexose synthase

642843

-

642843

r

additional information

?

-

Bifidobacterium bifidum

-

no activity with CDP-glucose

642826

-

-

?

additional information

?

-

Bifidobacterium bifidum

-

no activity with ADP-glucose or GDP-glucose

642826

-

-

?

additional information

?

-

Bifidobacterium bifidum

M4M7K7

no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate

737498

-

-

?

additional information

?

-

Bifidobacterium bifidum

M4MCS2

no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate

737498

-

-

?

additional information

?

-

Bifidobacterium bifidum

-

no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate

737498

-

-

?

additional information

?

-

Bifidobacterium bifidum PRL2010

M4M7K7

no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate

737498

-

-

?

additional information

?

-

Bifidobacterium bifidum PRL2010

M4MCS2

no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate

737498

-

-

?

additional information

?

-

Bos taurus

-

no activity with fructose 1-phosphate and galactose 6-phosphate

642828

-

-

?

additional information

?

-

Bos taurus

-

no activity with ADP-glucose or GDP-glucose

642828

-

-

?

additional information

?

-

Bos taurus

-

no activity with xylose 1-phosphate, and IDP-glucose

642828

-

-

?

additional information

?

-

Escherichia coli

-

no activity with fructose 1-phosphate and galactose 6-phosphate

642823

-

-

?

additional information

?

-

Escherichia coli

-

no activity with ADP-glucose or GDP-glucose

642823

-

-

?

additional information

?

-

Escherichia coli

-

no activity with ribose 1-phosphate and mannose 6-phosphate

642823

-

-

?

additional information

?

-

Escherichia coli

-

the enzyme has a strict requirement for UDP-glucose or UDP-galactose as substrates, while GDP-glucose, ADP-glucose, TDP-glucose, CDP-glucose, UDPxylose, and UDP-mannose are all unable to support activity

722427

-

-

?

additional information

?

-

Galdieria sulphuraria

-

no activity with UDP-xylose, ADP-glucose, and galactose 6-phosphate

642852

-

-

?

additional information

?

-

Homo sapiens

-

-

642828

-

-

?

additional information

?

-

Homo sapiens

-

inverse relationship between enzyme activity and galactose sensitivity

642861

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme has a strict requirement for UDP-glucose or UDP-galactose as substrates, while GDP-glucose, ADP-glucose, TDP-glucose, CDP-glucose, UDPxylose, and UDP-mannose are all unable to support activity

722427

-

-

?