2.7.7.12: UDP-glucose-hexose-1-phosphate uridylyltransferase

This is an abbreviated version!
For detailed information about UDP-glucose-hexose-1-phosphate uridylyltransferase, go to the full flat file.

Reaction

Synonyms

galactose 1-phosphate uridylyltransferase, galactose-1-phosphate uridyl transferase, galactose-1-phosphate uridyltransferase, galactose-1-phosphate uridylyltransferase, galactose-1-phosphate:uridyltransferase, GALT, GALT enzyme, GalT1, GalT2, hexose 1-phosphate uridyltransferase, hexose 1-phosphate uridylyltransferase, hexose-1-phosphate uridylyltransferase, UDP-Glc-hexose-1-P uridylyltransferase, UDP-glucose-hexose-1-P uridylyltransferase, UDPGlc:Gal-1-P uridylyltransferase, UDPglucose-hexose-1-phosphate uridylyltransferase, UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase, uridine diphosphoglucose:alpha-D-galactose-1-phosphate uridilyltransferase, uridyl transferase, uridyltransferase, uridylylgalactose-1-P uridylyltransferase, uridylyltransferase, hexose 1-phosphate

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.12 UDP-glucose-hexose-1-phosphate uridylyltransferase

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Results	in table
12	Activating Compound
20418	AA Sequence
8	Application
1	CAS Registry Number
29	Cloned(Commentary)
8	Crystallization (Commentary)
188	Disease/ Diagnostics
27	General Information
11	General Stability
71	Inhibitors
16	kcat/KM [mM/s]
8	Ki Value [mM]
122	KM Value [mM]
40	Metals/Ions
28	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
113	Organism
7	Pathway
11	PDB ID
21	pH Optimum
3	pH Range
5	pH Stability
3	pI Value
117	Protein Variants
38	Purification (Commentary)
32	Reaction
1	Reaction Type
92	Reference
1	Renatured (Commentary)
29	Source Tissue
72	Specific Activity [micromol/min/mg]
13	Storage Stability
148	Substrates and Products (Substrate)
27	Subunits
74	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
5	Temperature Range [°C]
9	Temperature Stability [°C]
36	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.7.7.12 - UDP-glucose-hexose-1-phosphate uridylyltransferase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,10-phenanthroline

2 entries

2,2'-bipyridyl

Escherichia coli

-

inactivation of the enzyme by chelation of Zn2+ and Fe2+ ions

642853

2-fluoro-galactose-1-phosphate

Homo sapiens

P07902

competitively inhibit recombinant enzyme

760856

-

8-hydroxyquinoline

Escherichia coli

-

inactivation of the enzyme by chelation of Zn2+ and Fe2+ ions

642853

8-Hydroxyquinoline sulfonate

Escherichia coli

-

inactivation of the enzyme by chelation of Zn2+ and Fe2+ ions

642853

ADP

2 entries

ADP-glucose

Homo sapiens

-

-

722427

alpha-D-galactose 1-phosphate

5 entries

alpha-D-glucose 1-phosphate

4 entries

ATP

2 entries

Ca2+

Bos taurus

-

-

642828, 642829

CDP-glucose

Homo sapiens

-

-

722427

Cl-

2 entries

Cu2+

Bos taurus

-

-

642828

cycloheximide

Homo sapiens

-

i.e. 3-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide; inhibition of de novo enzyme synthesis; mutant N314D is more sensitive than the wild-type

642844

D-galactose

2 entries

D-glucose 6-phosphate

Homo sapiens

-

erythrocytes

642835

diethyl dicarbonate

Escherichia coli

-

inactivates the enzyme, reversable by hydroxylamine

722427

diethyldicarbonate

Homo sapiens

-

erythrocytes

642835

DTNB

Escherichia coli

-

binds to SH-group in the active center

642834

GDP-glucose

Homo sapiens

-

-

722427

HgCl2

Bifidobacterium bifidum

-

94% inhibition at 0.2 mM

642826

iodoacetate

2 entries

Mg2+

Bos taurus

-

-

642828, 642829

Mn2+

Bos taurus

-

-

642828, 642829

NEM

2 entries

p-hydroxymercuribenzoate

Bos taurus

-

complete inhibition at 0.001 mM

642829

PCMB

2 entries

TDP-glucose

Homo sapiens

-

-

722427

UDP

2 entries

UDP-alpha-D-glucose

Homo sapiens

P07902

-

737739

UDP-galactose

3 entries

UDP-glucose

6 entries

UDP-glucuronic acid

Homo sapiens

-

-

722427

UDP-mannose

Homo sapiens

-

-

722427

UDP-xylose

Homo sapiens

-

-

722427

UMP

2 entries

Uracil

Homo sapiens

-

-

722427

uridine

Homo sapiens

-

-

722427

UTP

2 entries

additional information

3 entries

-

1,10-phenanthroline

Escherichia coli

-

inactivation of the enzyme by chelation of Zn2+ and Fe2+ ions, UDP-glucose protects, but alpha-D-glucose 1-phosphate does not

642853

1,10-phenanthroline

Escherichia coli

P09148

mutant E182A

642858

ADP

Homo sapiens

-

erythrocytes

642835

ADP

Homo sapiens

-

-

722427

alpha-D-galactose 1-phosphate

Escherichia coli

-

product/substrate inhibition

642838

alpha-D-galactose 1-phosphate

Escherichia coli

-

competitive substrate inhibition in the forward reaction

722427

alpha-D-galactose 1-phosphate

Homo sapiens

-

-

642838

alpha-D-galactose 1-phosphate

Homo sapiens

-

substrate inhibition at concentrations above 1.5 mM

642851

alpha-D-galactose 1-phosphate

Homo sapiens

-

competitive substrate inhibition in the forward reaction

722427

alpha-D-glucose 1-phosphate

Escherichia coli

-

product/substrate inhibition

642838

alpha-D-glucose 1-phosphate

Homo sapiens

-

erythrocytes

642835

alpha-D-glucose 1-phosphate

Homo sapiens

-

-

642838

alpha-D-glucose 1-phosphate

Homo sapiens

P07902

-

737739

ATP

Homo sapiens

-

erythrocytes

642835

ATP

Homo sapiens

-

-

722427

Cl-

Bos taurus

-

-

642835

Cl-

Homo sapiens

-

-

642835

D-galactose

Homo sapiens

-

wild-type and mutants, inverse relationship between enzyme activity and galactose sensitivity

642861

D-galactose

Homo sapiens

-

galactosemia, disease caused by genetic disorder, is characterized by a galactose sensitivity

642863

iodoacetate

Bifidobacterium bifidum

-

no inhibition

642826

iodoacetate

Homo sapiens

-

erythrocytes

642835

NEM

Bifidobacterium bifidum

-

no inhibition

642826

NEM

Escherichia coli

-

complete inhibition at 0.05 mM

642834

PCMB

Bifidobacterium bifidum

-

42% inhibition at 0.2 mM

642826

PCMB

Homo sapiens

-

erythrocytes

642835

UDP

Bos taurus

-

-

642835

UDP

Homo sapiens

-

-

722427

UDP-galactose

Escherichia coli

-

product/substrate inhibition

642838

UDP-galactose

Escherichia coli

-

the product of the forward reaction is a competitive inhibitor with respect to UDP-glucose and a mixed inhibitor with respect to galactose 1-phosphate

722427

UDP-galactose

Homo sapiens

-

the product of the forward reaction is a competitive inhibitor with respect to UDP-glucose and a mixed inhibitor with respect to galactose 1-phosphate

722427

UDP-glucose

Bos taurus

-

product inhibition

642835

UDP-glucose

Escherichia coli

-

product/substrate inhibition

642838

UDP-glucose

Homo sapiens

-

product inhibition

642835

UDP-glucose

Homo sapiens

-

-

642838

UDP-glucose

Homo sapiens

-

substrate inhibition at concentrations above 0.5 mM

642851

UDP-glucose

Homo sapiens

-

at high concentrations, wild-type and mutants F171L and F171S, not F171Y

642859

UMP

Bos taurus

-

-

642835

UMP

Homo sapiens

-

-

722427

UTP

Bos taurus

-

-

642835

UTP

Homo sapiens

-

-

722427

additional information

Bifidobacterium bifidum

-

no inhibition by NaF

642826

-

additional information

Escherichia coli

-

product inhibition study, wild-type and mutants H166G and H166A

642843

-

additional information

Galdieria sulphuraria

-

no inhibition by NADH, NAD+, sodium diphosphate

642852

-