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2.7.6.4: nucleotide diphosphokinase

This is an abbreviated version!
For detailed information about nucleotide diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.4

Reaction

ATP
+
nucleoside 5'-phosphate
=
AMP
 +
5'-phosphonucleoside 3'-diphosphate

Synonyms

ATP nucleotide 3'-pyrophosphokinase, ATP:nucleotide pyrophosphotransferase, nucleotide 3'-pyrophosphokinase, nucleotide pyrophosphokinase, nucleotide pyrophosphotransferase, pyrophosphokinase, nucleotide

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.6 Diphosphotransferases
                2.7.6.4 nucleotide diphosphokinase

Substrates Products

Substrates Products on EC 2.7.6.4 - nucleotide diphosphokinase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP
AMP + adenosine-3'-diphosphate-5'-triphosphate
show the reaction diagram
ATP + ADP
AMP + adenosine 3'-diphosphate 5'-diphosphate
show the reaction diagram
ATP + AMP
AMP + adenosine 3'-phosphate 5'-diphosphate
show the reaction diagram
ATP + GDP
AMP + guanosine 3'-diphosphate 5'-diphosphate
show the reaction diagram
ATP + GMP
AMP + guanosine 3'-phosphate 5'-diphosphate
show the reaction diagram
ATP + GTP
AMP + guanosine-3'-diphosphate-5'-triphosphate
show the reaction diagram
ATP + IDP
AMP + inosine 3'-diphosphate 5'-diphosphate
show the reaction diagram
ATP + IMP
AMP + inosine 3'-diphosphate 5'-phosphate
show the reaction diagram
ATP + ITP
AMP + inosine 3'-diphosphate 5'-triphosphate
show the reaction diagram
dATP + ADP
dAMP + adenosine 3'-diphosphate 5'-diphosphate
show the reaction diagram
dATP + AMP
dAMP + adenosine 3'-diphosphate 5'-phosphate
show the reaction diagram
-
-
-
-
?
dATP + ApG
dAMP + ApGpp
show the reaction diagram
-
-
-
-
?
dATP + ApUpG
dAMP + ApUpGpp
show the reaction diagram
-
-
-
-
?
dATP + ATP
dAMP + adenosine 3'-diphosphate 5'-triphosphate
show the reaction diagram
-
-
-
-
?
dATP + beta-NADH
dAMP + ?
show the reaction diagram
-
-
-
-
?
dATP + CTP
dAMP + cytidine 3'-diphosphate 5'-triphosphate
show the reaction diagram
-
-
-
-
?
dATP + GDP
dAMP + guanosine 3'-diphosphate 5'-diphosphate
show the reaction diagram
dATP + GDP-glucose
dAMP + ?
show the reaction diagram
-
-
-
-
?
dATP + GMP
dAMP + guanosine 3'-diphosphate 5'-phosphate
show the reaction diagram
-
-
-
-
?
dATP + GpA
dAMP + GpApp
show the reaction diagram
-
-
-
-
?
dATP + GpG
dAMP + GpGpp
show the reaction diagram
-
-
-
-
?
dATP + GTP
dAMP + guanosine 3'-diphosphate 5'-triphosphate
show the reaction diagram
dATP + IDP
dAMP + inosine 3'-diphosphate 5'-triphosphate
show the reaction diagram
-
-
-
-
?
dATP + IMP
dAMP + inosine 3'-diphosphate 5'-phosphate
show the reaction diagram
-
-
-
-
?
dATP + ITP
dAMP + inosine 3'-diphosphate 5'-triphosphate
show the reaction diagram
-
-
-
-
?
dATP + UDP-glucose
dAMP + ?
show the reaction diagram
-
-
-
-
?
dATP + UpG
dAMP + UpGpp
show the reaction diagram
-
-
-
-
?
dATP + UTP
dAMP + uridine 3'-diphosphate 5'-triphosphate
show the reaction diagram
-
-
-
-
?
pppApp + ADP
ppApp + ATP
show the reaction diagram
-
-
-
-
?
pppApp + GDP
ppGpp + ATP
show the reaction diagram
-
-
-
-
?
pppApp + GTP
pppGpp + ATP
show the reaction diagram
-
32.2% of the activity with GTP as substrate
-
-
?
additional information
?
-
-
dinucleotide 3',5'-diphosphodiester linkages, namely pAppA, ppAppA, and pppAppA are formed as transient intermediate during the diphosphokinase-catalyzed reaction of ApppA, AppppA, and ApppppA leading to the synthesis of pAp, ppAp and pppAp, which in turn is further converted to pAp, respectively
-
-
?