2.7.6.2: thiamine diphosphokinase
This is an abbreviated version!
For detailed information about thiamine diphosphokinase, go to the full flat file.
Word Map on EC 2.7.6.2
-
2.7.6.2
-
pyrophosphate
-
dihydropteroate
-
pyrophosphorylated
-
tdp
-
ribosephosphate
-
hydroxymethyldihydropterin
-
pyrithiamine
-
6-hydroxymethyl-7,8-dihydropterin
-
dihydroneopterin
-
thiamine-responsive
-
oxythiamine
-
megaloblastic
-
medicine
- 2.7.6.2
- pyrophosphate
- dihydropteroate
-
pyrophosphorylated
- tdp
-
ribosephosphate
-
hydroxymethyldihydropterin
- pyrithiamine
- 6-hydroxymethyl-7,8-dihydropterin
- dihydroneopterin
-
thiamine-responsive
- oxythiamine
-
megaloblastic
- medicine
Reaction
Synonyms
At1g02880 (AtTPK1), At2g44750 (AtTPK2), ATP:thiamin pyrophosphotransferase, CA1462, hTPK1, Plasmodium falciparum thiamine pyrophosphokinase, pyrophosphokinase, pyrophosphokinase, thiamin, TDPK, thiamin kinase, thiamin pyrophosphokinase, thiamin pyrophosphotransferase, thiamin:ATP pyrophosphotransferase, thiamine diphosphokinase, thiamine kinase, thiamine pyrophokinase, thiamine pyrophosphokinase, thiaminokinase, TPK, Tpk1, TPTase, YcfN
ECTree
2.7.6.2 thiamine diphosphokinaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.7.6.2 - thiamine diphosphokinase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + thiamine
AMP + thiamine diphosphate
thiamine pyrophosphokinase is required for thiamine cofactor activation in Arabidopsis
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
no TMP kinase activity is shown by either isozymes TPK1 or TPK2
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
the tpk-1 gene functions cell nonautonomously, as the expression of wild-type tpk-1 in one tissue can residue the function of other tissues that express only mutant tpk-1. Thiamine diphosphate can be transported across the cell membrane
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
the enzyme is important for the formation of the coenzyme thiamine diphosphate
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
enzyme is involved in biosynthesis of thiamine diphosphate
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
the enzyme is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth
-
-
?
CTP + thiamine
CMP + thiamine diphosphate
31.4% of the activity with ATP
-
-
?
GTP + thiamine
GMP + thiamine diphosphate
-
GTP is the preferred nucleotide
-
-
?
GTP + thiamine
GMP + thiamine diphosphate
18.3% of the activity with ATP
-
-
?
pyrithiamine + ATP
pyrithiamine diphosphate + AMP
-
inhibits the substrate thiamine
-
-
?
pyrithiamine + ATP
pyrithiamine diphosphate + AMP
-
its specific activity is 30% lower in comparison to its natural substrate thiamine
-
-
?
thiamine + ATP
thiamine diphosphate + AMP
-
TPP plays a critical role in the carbohydrate and energy metabolism. It functions as a prosthetic group for the mitochondrial enzyme complexes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and branched chain alpha-keto acid dehydrogenase. In addition, TPP is involved in the cytosolic pentose pathway functioning as coenzyme for transketolase.
-
-
?
UTP + thiamine
UMP + thiamine diphosphate
207% of the activity with ATP
-
-
?
additional information
?
-
-
thiamine binding site structure, overview
-
-
?
additional information
?
-
-
three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight, overview
-
-
?
additional information
?
-
-
the YcfN protein acts as a nonspecific adenosylcobinamide kinase enzyme, which is not associated with adenosylcobalamine biosynthesis, but it allows a CobU-deficient strain of serovar Typhimurium to synthesize enough adenosylcobalamine from cobinamide so that the cell can grow. YcfN is required for the phosphorylation of thiamine in the thiamine salvaging pathway of Escherichia coli
-
-
?
