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2.7.6.2: thiamine diphosphokinase

This is an abbreviated version!
For detailed information about thiamine diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.2

Reaction

ATP
+
thiamine
=
AMP
+
thiamine diphosphate

Synonyms

At1g02880 (AtTPK1), At2g44750 (AtTPK2), ATP:thiamin pyrophosphotransferase, CA1462, hTPK1, Plasmodium falciparum thiamine pyrophosphokinase, pyrophosphokinase, pyrophosphokinase, thiamin, TDPK, thiamin kinase, thiamin pyrophosphokinase, thiamin pyrophosphotransferase, thiamin:ATP pyrophosphotransferase, thiamine diphosphokinase, thiamine kinase, thiamine pyrophokinase, thiamine pyrophosphokinase, thiaminokinase, TPK, Tpk1, TPTase, YcfN

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.6 Diphosphotransferases
                2.7.6.2 thiamine diphosphokinase

Reference

Reference on EC 2.7.6.2 - thiamine diphosphokinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Steyn-Parve, E.P.
Partial purification and properties of thiaminokinase from yeast
Biochim. Biophys. Acta
8
310-324
1952
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Onozuka, M.; Nosaka, K.
Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase
J. Nutr. Sci. Vitaminol.
49
156-162
2003
Homo sapiens (Q9H3S4), Homo sapiens
Manually annotated by BRENDA team
Howle, P.K.W.; Fites, R.C.
GTP-specific pyrophosphorylation of thiamin in dark-grown soybean (Glycine max) seddling axes
Physiol. Plant.
81
24-30
1991
Glycine max
-
Manually annotated by BRENDA team
Mitsuda, H.; Takii, Y.; Iwami, K.; Yasumoto, K.
Mechanism and regulation of thiamine pyrophosphokinase from parsely leaf
J. Nutr. Sci. Vitaminol.
21
189-198
1975
Petroselinum crispum
Manually annotated by BRENDA team
Mitsuda, H.; Takii, Y.; Kimikazu, I.; Yasumoto, K.
Purification and properties of thiamine pyrophosphokinase from parsely leaf
J. Nutr. Sci. Vitaminol.
21
103-115
1975
Petroselinum crispum
Manually annotated by BRENDA team
Wakabayashi, Y.; Iwashima, A.; Nose, Y.
Affinity chromatography of thiamine pyrophosphokinase from rat brain on thiamine monophosphate-agarose
Methods Enzymol.
62
105-107
1979
Rattus norvegicus
Manually annotated by BRENDA team
Mitsuda, H.; Takii, Y.; Iwami, K.; Yasumoto, K.; Nakajima, K.
Enzymatic formation of thiamine pyrophosphate in plants
Methods Enzymol.
62
107-111
1979
Petroselinum crispum
Manually annotated by BRENDA team
Sanemori, H.; Kawasaki, T.
Purification and properties of thiamine pyrophosphokinase in Paracoccus denitrificans
J. Biochem.
88
223-230
1980
Paracoccus denitrificans, Paracoccus denitrificans 12442
Manually annotated by BRENDA team
Wakabayashi, Y.; Iwashima, A.; Nose, Y.
Affinity chromatohraphy of thiamin pyrophosphokinase of rat brain
Biochim. Biophys. Acta
429
1087-1089
1976
Rattus norvegicus
-
Manually annotated by BRENDA team
Peterson, J.W.; Gubler, C.J.; Kuby, S.A.
Partial purification and properties of thiamine pyrophosphokinase from pig brain
Biochim. Biophys. Acta
397
377-394
1975
Sus scrofa
Manually annotated by BRENDA team
Okazaki, K.
Evidence for existence and a tentative identification of coenzyme in yeast thiamine pyrophosphokinase
Biochem. Biophys. Res. Commun.
64
20-27
1975
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Molin, W.T.; Fites, R.C.
Isolation and characterization of thiamin pyrophosphotransferase from Glycine max seedlings
Plant Physiol.
66
308-312
1980
Glycine max
Manually annotated by BRENDA team
Baker, L.J.; Dorocke, J.A.; Harris, R.A.; Timm, D.E.
The crystal structure of yeast thiamin pyrophosphokinase
Structure
9
539-546
2001
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Zhao, R.; Gao, F.; Goldman, I.D.
Molecular cloning of human thiamin pyrophosphokinase
Biochim. Biophys. Acta
1517
320-322
2001
Homo sapiens (Q9H3S4), Homo sapiens
Manually annotated by BRENDA team
Timm, D.E.; Liu, J.; Baker, L.J.; Harris, R.A.
Crystal structure of thiamin pyrophosphokinase
J. Mol. Biol.
310
195-204
2001
Mus musculus
Manually annotated by BRENDA team
Frankhauser, H.; Zurlinden, A.; Schweingruber, A.M.; Edenharter, E.; Schweingruber, M.E.
Schizosaccharomyces pombe thiamin pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamin metabolism, phosphate metabolism, mating, and growth
J. Biol. Chem.
270
28457-28462
1995
Schizosaccharomyces pombe (P41888), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Melnick, J.S.; Sprinz, K.I.; Reddick, J.J.; Kinsland, C.; Begley, T.P.
An efficient enzymatic synthesis of thiamin pyrophosphate
Bioorg. Med. Chem. Lett.
13
4139-4141
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
de Jong, L.; Meng, Y.; Dent, J.; Hekimi, S.
Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans
Genetics
168
845-854
2004
Caenorhabditis elegans (P30636), Caenorhabditis elegans
Manually annotated by BRENDA team
Eschbach, M.L.; Mueller, I.B.; Gilberger, T.W.; Walter, R.D.; Wrenger, C.
The human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamine
Biol. Chem.
387
1583-1591
2006
Saccharomyces cerevisiae, Plasmodium falciparum, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Fraccascia, P.; Sniekers, M.; Casteels, M.; Van Veldhoven, P.P.
Presence of thiamine pyrophosphate in mammalian peroxisomes
BMC Biochem.
8
10
2007
Rattus norvegicus, Mus musculus (Q59Q36)
Manually annotated by BRENDA team
Otte, M.M.; Woodson, J.D.; Escalante-Semerena, J.C.
The thiamine kinase (YcfN) enzyme plays a minor but significant role in cobinamide salvaging in Salmonella enterica
J. Bacteriol.
189
7310-7315
2007
Salmonella enterica
Manually annotated by BRENDA team
Liu, J.; Timm, D.E.; Hurley, T.D.
Pyrithiamine as a substrate for thiamine pyrophosphokinase
J. Biol. Chem.
281
6601-6607
2006
Mus musculus
Manually annotated by BRENDA team
Ajjawi, I.; Rodriguez Milla, M.A.; Cushman, J.; Shintani, D.K.
Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis
Plant Mol. Biol.
65
151-162
2007
Arabidopsis thaliana, Arabidopsis thaliana (F4IV16)
Manually annotated by BRENDA team
Fradin, D.; Bougneres, P.
Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight
Ann. Hum. Genet.
71
578-585
2007
Homo sapiens
Manually annotated by BRENDA team
Santini, S.; Monchois, V.; Mouz, N.; Sigoillot, C.; Rousselle, T.; Claverie, J.; Abergel, C.
Structural characterization of CA1462, the Candida albicans thiamine pyrophosphokinase
BMC Struct. Biol.
8
33
2008
Candida albicans
Manually annotated by BRENDA team
Yuge, S.; Richter, C.A.; Wright-Osment, M.K.; Nicks, D.; Saloka, S.K.; Tillitt, D.E.; Li, W.
Identification of the thiamin pyrophosphokinase gene in rainbow trout: characteristic structure and expression of seven splice variants in tissues and cell lines and during embryo development
Comp. Biochem. Physiol. B
163
193-202
2012
Oncorhynchus mykiss (I3PU26)
Manually annotated by BRENDA team
Liu, J.Y.; Hurley, T.D.
A new crystal form of mouse thiamin pyrophosphokinase
Int. J. Biochem. Mol. Biol.
2
111-118
2011
Mus musculus
Manually annotated by BRENDA team
Krautwald, M.; Leech, D.; Horne, S.; Steele, M.L.; Forbes, J.; Rahmadi, A.; Griffith, R.; Muench, G.
The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase
Rejuvenation Res.
14
383-391
2011
Homo sapiens
Manually annotated by BRENDA team
Banka, S.; de Goede, C.; Yue, W.W.; Morris, A.A.; von Bremen, B.; Chandler, K.E.; Feichtinger, R.G.; Hart, C.; Khan, N.; Lunzer, V.; Matakovi?, L.; Marquardt, T.; Makowski, C.; Prokisch, H.; Debus, O.; Nosaka, K.; Sonwalkar, H.; Zimmermann, F.A.; Sperl, W.; Mayr, J.A.
Expanding the clinical and molecular spectrum of thiamine pyrophosphokinase deficiency: a treatable neurological disorder caused by TPK1 mutations
Mol. Genet. Metab.
113
301-306
2014
Homo sapiens (Q9H3S4), Homo sapiens
Manually annotated by BRENDA team
Jonus, H.C.; Hanberry, B.S.; Khatu, S.; Kim, J.; Luesch, H.; Dang, L.H.; Bartlett, M.G.; Zastre, J.A.
The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions
Oncotarget
9
35422-35438
2018
Homo sapiens (Q9H3S4)
Manually annotated by BRENDA team
Parkhomenko, Y.; Pavlova, A.; Mejenskaya, O.; Stepanenko, S.; Chekhivska, L.
Thiamine diphosphate synthesis and redox state indicator in the rat brain during B1 hypovitaminosis
Ukr. Biochem. J.
89
84-95
2017
Rattus norvegicus (B5DEJ6)
-
Manually annotated by BRENDA team