2.7.6.1: ribose-phosphate diphosphokinase
This is an abbreviated version!
For detailed information about ribose-phosphate diphosphokinase, go to the full flat file.
Word Map on EC 2.7.6.1
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2.7.6.1
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purine
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erythrocyte
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superactivity
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pyrimidine
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x-linked
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phosphoribosyltransferase
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uric
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gout
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hypoxanthine
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hypoxanthine-guanine
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deafness
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charcot-marie-tooth
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sensorineural
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hemolysates
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diphosphorylated
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nonsyndromic
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hgprt
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hyperuricaemia
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lesch-nyhan
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phosphoribosyl-pyrophosphate
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feedback-resistant
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synthesis
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medicine
- 2.7.6.1
- purine
- erythrocyte
-
superactivity
- pyrimidine
-
x-linked
- phosphoribosyltransferase
-
uric
- gout
- hypoxanthine
-
hypoxanthine-guanine
- deafness
- charcot-marie-tooth
-
sensorineural
-
hemolysates
-
diphosphorylated
-
nonsyndromic
- hgprt
-
hyperuricaemia
- lesch-nyhan
-
phosphoribosyl-pyrophosphate
-
feedback-resistant
- synthesis
- medicine
Reaction
Synonyms
5-phospho-alpha D-ribosyl 1-diphosphate synthase, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-1-alpha-diphosphate synthase, 5-phosphoribosyl-1-pyrophosphate synthetase, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase, AN6711.2, ATP: D-ribose-5-phosphate pyrophosphotransferase, ATP:D-ribose-5-phosphate pyrophosphotransferase, bsPRS, Pcal_1127, phosphoribosyl diphosphate synthase, phosphoribosyl pyrophosphate synthase 1 (PRS-1), phosphoribosyl pyrophosphate synthase enzyme, phosphoribosyl pyrophosphate synthetase, phosphoribosyl-1-pyrophosphate synthetase, phosphoribosyl-diphosphate synthetase, phosphoribosylpyrophosphate synthase, phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate synthetase 1, phosphoribosylpyrophosphate synthetase subunit 1, PP-ribose P synthetase, PPRibP synthetase, PRibPP synthase, PRPP synthase, PRPP synthetase, PRPPase, PRPPS, PRPPS1, PRPPS2, PRPS1, Prps1a, Prps1b, PRS, PRS-I, PRS1, Prs4, PrsA, PrsB, PrsC, pyrophosphokinase, ribose phosphate, pyrophosphoribosylphosphate synthetase, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase 1, RPPK, SSO1045, TT_C1184, TT_C1274
ECTree
2.7.6.1 ribose-phosphate diphosphokinaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.7.6.1 - ribose-phosphate diphosphokinase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
additional information
additional information
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increasing phosphate concentrations, increases Km values for ATP and D-ribose-5-phosphate
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1.923
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine
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pH 8.0, 37ÂșC, isoenzyme I
3.636
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine
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pH 8.0, 37ÂșC, isoenzyme I
0.317
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
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pH 8.0, 37ÂșC, isoenzyme II
0.323
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
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pH 8.0, 37ÂșC, isoenzyme I
0.377
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
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pH 8.0, 37ÂșC
0.0289
5-phospho-alpha-D-ribose 1-diphosphate
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pH 7.4, 37ÂșC, native enzyme from liver
0.0402
5-phospho-alpha-D-ribose 1-diphosphate
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pH 7.4, 37ÂșC, isoenzyme rPRSII
0.0418
5-phospho-alpha-D-ribose 1-diphosphate
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pH 7.4, 37ÂșC, isoenzyme rPRSI
0.29
5-phospho-D-ribose diphosphate
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pH and temperature conditions not mentioned
0.29
5-phospho-D-ribose diphosphate
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pH and temperature conditions not mentioned
0.32
AMP
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pH and temperature conditions not mentioned
0.046
ATP
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pH and temperature conditions not mentioned
0.046
ATP
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ATP in form of MgATP2-
0.05
ATP
wild type enzyme, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.06
ATP
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pH 7.5, 37ÂșC, excess of Mn2+
0.06
ATP
mutant enzyme N120S, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.083
ATP
mutant enzyme D58H, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.094
ATP
mutant enzyme L135I, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.1
ATP
-
pH 7.5, 37ÂșC, excess of Mg2+, bimodal kinetic behavior
0.35
ATP
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pH 7.5, 37ÂșC, no excess of Mn2+
0.58
ATP
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pH 7.5, 37ÂșC, excess of Mg2+, bimodal kinetic behavior
2.6
ATP
pH and temperature not specified in the publication
2.9
ATP
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pH 7.5, 37ÂșC, no excess of Mg2+
0.014
D-ribose 5-phosphate
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cosubstrate ATP, in 50 mM Tris-HCl pH 8.0, at 25°C
0.05 - 0.13
D-ribose 5-phosphate
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pH 7.5, 37ÂșC
0.052
D-ribose 5-phosphate
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pH and temperature conditions not mentioned, rPRSI isoenzyme
0.06
D-ribose 5-phosphate
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in the presence of 5 mM Mn2+, in 50 mM potassium phosphate pH 8.0, at 37°C
0.07
D-ribose 5-phosphate
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in the presence of 5 mM Mg2+, in 50 mM potassium phosphate pH 8.0, at 37°C
0.071
D-ribose 5-phosphate
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in the absence of Mg2+ or Mn2+, in 50 mM potassium phosphate pH 8.0, at 37°C
0.083
D-ribose 5-phosphate
-
pH and temperature conditions not mentioned, rPRSII isoenzyme
0.105
D-ribose 5-phosphate
wild type enzyme, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.157
D-ribose 5-phosphate
mutant enzyme D58H, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.16
D-ribose 5-phosphate
-
pH and temperature conditions not mentioned
0.18
D-ribose 5-phosphate
mutant enzyme N120S, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.189
D-ribose 5-phosphate
mutant enzyme L135I, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.298
D-ribose 5-phosphate
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pH 8.0, 37ÂșC
0.57
D-ribose 5-phosphate
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pH conditions not mentioned, 37ÂșC, wild type enzyme
2.8
D-ribose 5-phosphate
pH and temperature not specified in the publication
0.6
Mg2+
-
pH and temperature conditions not mentioned
2.3
phosphate
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pH 7.5, 37ÂșC, high affinity site
40
phosphate
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pH 7.5, 37ÂșC, low affinity site
