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2.7.6.1: ribose-phosphate diphosphokinase

This is an abbreviated version!
For detailed information about ribose-phosphate diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.1

Reaction

ATP
+
D-ribose 5-phosphate
=
AMP
+
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

5-phospho-alpha D-ribosyl 1-diphosphate synthase, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-1-alpha-diphosphate synthase, 5-phosphoribosyl-1-pyrophosphate synthetase, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase, AN6711.2, ATP: D-ribose-5-phosphate pyrophosphotransferase, ATP:D-ribose-5-phosphate pyrophosphotransferase, bsPRS, Pcal_1127, phosphoribosyl diphosphate synthase, phosphoribosyl pyrophosphate synthase 1 (PRS-1), phosphoribosyl pyrophosphate synthase enzyme, phosphoribosyl pyrophosphate synthetase, phosphoribosyl-1-pyrophosphate synthetase, phosphoribosyl-diphosphate synthetase, phosphoribosylpyrophosphate synthase, phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate synthetase 1, phosphoribosylpyrophosphate synthetase subunit 1, PP-ribose P synthetase, PPRibP synthetase, PRibPP synthase, PRPP synthase, PRPP synthetase, PRPPase, PRPPS, PRPPS1, PRPPS2, PRPS1, Prps1a, Prps1b, PRS, PRS-I, PRS1, Prs4, PrsA, PrsB, PrsC, pyrophosphokinase, ribose phosphate, pyrophosphoribosylphosphate synthetase, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase 1, RPPK, SSO1045, TT_C1184, TT_C1274

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.6 Diphosphotransferases
                2.7.6.1 ribose-phosphate diphosphokinase

Inhibitors

Inhibitors on EC 2.7.6.1 - ribose-phosphate diphosphokinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
2,3-diphosphoglycerate
2-deoxy-D-ribose 5-phosphate
-
92% inhibition at 1 mM
5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethoxy)adenine
9-(2-phosphonylmethoxyethyl)adenine
adenosine
adenosine 5'-(beta,gamma-imido)-triphosphate
-
inhibition at 1 mM
allopurinol ribonucleotides
-
23% inhibition at 1 mM
alpha,beta-methylene ATP
-
alpha,beta-methyleneATP
D-fructose 1,6-diphosphate
D-Fructose 1-phosphate
D-ribose 1-phosphate
-
13% inhibition at 1 mM
D-ribose 5-phosphate
dATP
-
inhibition at 1 mM
diadenosine pentaphosphate
Inhibits the dephosphorylation of ATP and ADP by nonspecific phosphatases.
DL-1,4-Anhydroribitol 5-phosphate
-
competitive inhibition to D-ribose-5-phosphate
FAD
-
51% inhibition at 1 mM
glyceraldehyde 3-phosphate
GSH
-
marked inhibition of enzyme in crude extract at 1 mM
guanosine
IMP
-
21% inhibition at 1 mM
L-histidine
L-tryptophan
Mn2+
-
complete inhibition above 0.4 mM
NAD+
-
100% inhibition at 1 mM
NADH
-
72% inhibition at 1 mM
NADPH
-
100% inhibition at 1 mM
nucleotides
-
phosphate
PRPP synthetase-associated proteins
-
SO42-
-
1 M, strong inhibition
TTP
-
47% inhibition at 1 mM
XDP
-
36% inhibition at 1 mM
XTP
-
22% inhibition at 1 mM
additional information
-