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2.7.6.1: ribose-phosphate diphosphokinase

This is an abbreviated version!
For detailed information about ribose-phosphate diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.1

Reaction

ATP
+
D-ribose 5-phosphate
=
AMP
+
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

5-phospho-alpha D-ribosyl 1-diphosphate synthase, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-1-alpha-diphosphate synthase, 5-phosphoribosyl-1-pyrophosphate synthetase, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase, AN6711.2, ATP: D-ribose-5-phosphate pyrophosphotransferase, ATP:D-ribose-5-phosphate pyrophosphotransferase, bsPRS, Pcal_1127, phosphoribosyl diphosphate synthase, phosphoribosyl pyrophosphate synthase 1 (PRS-1), phosphoribosyl pyrophosphate synthase enzyme, phosphoribosyl pyrophosphate synthetase, phosphoribosyl-1-pyrophosphate synthetase, phosphoribosyl-diphosphate synthetase, phosphoribosylpyrophosphate synthase, phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate synthetase 1, phosphoribosylpyrophosphate synthetase subunit 1, PP-ribose P synthetase, PPRibP synthetase, PRibPP synthase, PRPP synthase, PRPP synthetase, PRPPase, PRPPS, PRPPS1, PRPPS2, PRPS1, Prps1a, Prps1b, PRS, PRS-I, PRS1, Prs4, PrsA, PrsB, PrsC, pyrophosphokinase, ribose phosphate, pyrophosphoribosylphosphate synthetase, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase 1, RPPK, SSO1045, TT_C1184, TT_C1274

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.6 Diphosphotransferases
                2.7.6.1 ribose-phosphate diphosphokinase

Cloned

Cloned on EC 2.7.6.1 - ribose-phosphate diphosphokinase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Aedes albopictus C6/36 cell line
expressed in Escherichia coli
expressed in Escherichia coli BL21(AI) cells
-
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3)pLysS cells
-
expressed in Escherichia coli C41 cells
-
expression in Escherichia coli
expression of isoenzyme 3 in Escherichia coli
-
expression of isoenzymes PRS1, PRS2, PRS3 and PRS4 in Escherichia coli
-
expression of isoenzymes PRSI and PRSII in Escherichia coli
expression of the five PRS genes individually in an Escherichia coli PRPP-less strain shows that a single PRS gene product has no PRPP synthase activity. Certain pairwise combinations of subunits produce an active enzyme, yeast PRPP synthase requires at least three different subunits to be stable in vitro
-
gene Pcal_1127, DNA and amino acid sequence determination and analysis, phylogenetic analysis, recombinant expression in Escherichia coli strain BL21-CodonPlus(DE3)-RIL
gene PRPS1, genomic structure, genotyping in European and Asian individuals
gene PRS1 from a cDNA library, expression of the His-tagged enzyme in Escherichia coli strain BL21(DE3)
genes AGR371C and AGL080C, overexpression of wild-type and mutant deregulated isozymes Agr371cp and Agl080cp, phylogenetic tree of the PRS proteins from Ashbya gossypii and Saccharomyces cerevisiae
-
overexpression of wild-type and mutant enzymes in Arabidopsis thaliana and Nicotiana tabacum, ectopic expression of heterologous PRS activity in the cytosol
-
produced in an Escherichia coli strain lacking endogenous phosphoribosyl diphosphate synthase activity
-