2.7.4.8: guanylate kinase

This is an abbreviated version!
For detailed information about guanylate kinase, go to the full flat file.

Word Map on EC 2.7.4.8

2.7.4.8

junction

synapses

drosophila

nmda

cell-cell

src

excitatory

synapse-associated

hippocampal

domain-containing

magi-1

adaptor

spine

palmitoylated

n-methyl-d-aspartate

presynaptic

glutamatergic

kinase-like

adherens

pdz-binding

zonula

carma1

crumbs

bcl10

neurexins

discs-large

dgmp

septate

occludens

kinase-associated

junction-associated

tcr-induced

ampars

shank

mucosa-associated

card-containing

neuroligins

drug development

medicine

Reaction

Synonyms

5'-GMP kinase, apo-EcGMPK, ATP: GMP phosphotransferase, ATP:GMP phosphotransferase, BmGK, CASK polypeptide, Cavbeta1b, Cavbeta2a, deoxyguanylate kinase, DLG1/SAP97, ecGMPK, GK, GK3, GKc, GKpm, GMK, GMK3, GMP kinase, GMPK, guanosine monophosphate kinase, guanosine monophosphate kinase (EcGMPK), guanylate kinase, guanylate kinase (GK), guanylate monophosphate kinase, GUK, kinase, guanylate (phosphorylating), MAGUK, MAGUK PSD-95, MAGUKs, membrane associated guanylate kinase, membrane associated guanylate kinase protein, membrane-associated guanylate kinase, membrane-associated guanylate kinases, MoGuk1, MoGuk2, More, organellar GK, post-synaptic density-95 membrane associated guanylate kinase, postsynaptic density protein-95 SH3 GK, PSD-95 GK, PSD-95 MAGUK, PSD-95alpha, PSD-95beta, Staphylococcus aureus guanylate monophosphate kinase, voltage-gated calcium channel beta1b, voltage-gated calcium channel beta2a, YGK

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.8 guanylate kinase

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Results	in table
2	Activating Compound
41441	AA Sequence
3	Application
1	CAS Registry Number
31	Cloned(Commentary)
11	Cofactor
12	Crystallization (Commentary)
296	Disease/ Diagnostics
2	Expression
34	General Information
8	General Stability
3	IC50 Value
78	Inhibitors
14	kcat/KM [mM/s]
23	Ki Value [mM]
86	KM Value [mM]
33	Localization
105	Metals/Ions
20	Molecular Weight [Da]
43	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
271	Organism
6	Pathway
83	PDB ID
19	pH Optimum
7	pH Range
3	pH Stability
4	pI Value
4	Posttranslational Modification
24	Protein Variants
37	Purification (Commentary)
4	Reaction
9	Reaction Type
76	Reference
3	Renatured (Commentary)
41	Source Tissue
21	Specific Activity [micromol/min/mg]
17	Storage Stability
217	Substrates and Products (Substrate)
15	Subunits
86	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
28	Turnover Number [1/s]

KM Value

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KM Value on EC 2.7.4.8 - guanylate kinase

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0.052

(R)-ganciclovir phosphonate

Homo sapiens

pH 7.5, 37ºC

642704

2.1

6-thioguanosine 5'-monophosphate

Homo sapiens

pH 7.5, 30ºC

642688

0.013 - 0.091

8-azaguanosine 5'-monophosphate

3 entries

0.25

9-(5-phosphonopentyl)guanine

Sus scrofa

pH 7.5, 30ºC

642697

23.6

Adenosine triphosphate

Rickettsia conorii

Q92GC9

675894

0.12 - 1

ATP

6 entries

1.25

Co2+

Escherichia coli

642687

0.01 - 0.4

dGMP

16 entries

0.045 - 0.054

ganciclovir monophosphate

2 entries

0.097

GDP

Saccharomyces cerevisiae

pH 7.5, 25ºC

642701

0.002 - 1.8

GMP

39 entries

0.0051

guanosine monophosphate

Rickettsia conorii

Q92GC9

675894

10.8 - 347

K+

Mg2+

0.017

MgADP-

Saccharomyces cerevisiae

pH 7.5, 25ºC

642701

0.2 - 0.45

MgATP2-

5 entries

0.75

Mn2+

NH4+

additional information

4 entries