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2',3'-dehydro-3'-deoxyTDP + ATP
2',3'-dehydro-3'-deoxyTTP + ADP
-
-
-
?
3'-fluoro-2',3'-dideoxyUDP + ATP
3'-fluoro-2',3'-dideoxyUTP + ADP
better than 2,3-dideoxyUDP, but much poorer than 2-deoxyUDP
-
-
?
3'-fluoro-3'-deoxyTDP + ATP
3'-fluoro-3'-deoxyTTP + ADP
-
-
-
?
ADP + dADP
AMP + dATP
-
-
-
r
ADP + dCDP
AMP + dCTP
low activity
-
-
r
ADP + dCTP
ATP + dCDP
-
-
-
-
?
ADP + dGDP
AMP + dGTP
-
-
-
r
ADP + dTTP
ATP + dTDP
-
-
-
-
?
ADP + dUTP
ATP + dUDP
-
-
-
-
?
ADP + ITP
ATP + IDP
-
-
-
?
ATP + 8-bromo-IDP
ADP + ?
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
ATP + adenosine 5'-methylene diphosphonate
ADP + ?
-
-
-
?
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
ATP + tubulin-GDP
ADP + tubulin-GTP
-
-
-
?
ATP + XDP
ADP + XTP
-
reaction at 37% the rate of UDP
-
-
?
CTP + ADP
CDP + ATP
-
-
-
?
dATP + CDP
dADP + CTP
-
-
-
r
dATP + GDP
dADP + GTP
-
-
-
?
dATP + IDP
dADP + ITP
-
-
-
?
dATP + UDP
dADP + UTP
-
-
-
?
dGDP + ATP
dGTP + ADP
-
-
-
-
?
gamma-S-ATP + GDP
ADP + gamma-S-GTP
gamma-S-GTP + GDP
GDP + gamma-S-GTP
GDP + ATP
GTP + ADP
-
-
-
?
GTP + dGDP
GDP + dGTP
-
-
-
-
?
GTP + dTDP
GDP + dTTP
-
-
-
-
?
GTP + nucleoside diphosphate
GDP + nucleoside triphosphate
GTP-bound Ras protein + NDP
GDP-bound Ras protein + NTP
-
in vitro, inactivation of mutant oncogenic Ras proteins
-
-
?
ITP + UDP
IDP + UTP
-
-
-
-
?
NTP + ADP
NDP + ATP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
TTP + ADP
TDP + ATP
-
-
-
?
tubulin-GDP-complex + ATP
tubulin-GTP-complex + ADP
-
-
-
-
?
UTP + ADP
UDP + ATP
-
-
-
?
UTP + UDP
UDP + UTP
-
reaction at 31% the rate of ATP
-
?
additional information
?
-
ADP + ATP
ATP + ADP
-
-
-
?
ADP + ATP
ATP + ADP
-
-
-
?
ADP + CTP
ATP + CDP
-
-
-
-
?
ADP + CTP
ATP + CDP
-
-
-
?
ADP + CTP
ATP + CDP
-
-
-
?
ADP + CTP
ATP + CDP
-
-
-
-
?
ADP + CTP
ATP + CDP
-
-
-
?
ADP + dGTP
ATP + dGDP
-
-
-
?
ADP + dGTP
ATP + dGDP
-
-
-
?
ADP + GTP
ATP + GDP
-
-
-
-
?
ADP + GTP
ATP + GDP
-
-
-
?
ADP + GTP
ATP + GDP
-
-
-
?
ADP + GTP
ATP + GDP
-
-
-
-
?
ADP + GTP
ATP + GDP
-
-
-
?
ADP + GTP
ATP + GDP
-
-
-
-
?
ADP + GTP
ATP + GDP
-
-
-
?
ADP + TTP
ATP + TDP
-
-
-
?
ADP + TTP
ATP + TDP
-
-
-
-
?
ADP + UTP
ATP + UDP
-
-
-
-
?
ADP + UTP
ATP + UDP
-
-
-
?
ADP + UTP
ATP + UDP
-
-
-
?
ATP + 8-bromo-IDP
ADP + ?
-
-
-
?
ATP + 8-bromo-IDP
ADP + ?
-
-
-
?
ATP + 8-bromo-IDP
ADP + ?
-
-
-
?
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
-
-
-
?
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
-
-
-
?
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
-
-
-
?
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
-
-
-
?
ATP + ADP
ADP + ATP
-
best substrate
-
?
ATP + ADP
ADP + ATP
-
-
-
r
ATP + ADP
ADP + ATP
-
-
-
?
ATP + ADP
ADP + ATP
-
-
-
-
?
ATP + ADP
ADP + ATP
-
less effective dinucleotide substrate
-
?
ATP + ADP
ADP + ATP
-
-
-
?
ATP + ADP
ADP + ATP
-
reaction at 94% the rate of UDP
-
?
ATP + CDP
ADP + CTP
-
-
-
-
?
ATP + CDP
ADP + CTP
-
-
-
?
ATP + CDP
ADP + CTP
-
-
-
-
?
ATP + CDP
ADP + CTP
-
reverse reaction at 21% the rate of ATP plus ADP
-
r
ATP + CDP
ADP + CTP
-
-
-
-
?
ATP + CDP
ADP + CTP
-
-
-
-
r
ATP + CDP
ADP + CTP
-
-
-
-
r
ATP + CDP
ADP + CTP
-
-
-
-
r
ATP + CDP
ADP + CTP
-
-
-
-
r
ATP + CDP
ADP + CTP
-
-
-
-
r
ATP + CDP
ADP + CTP
-
-
-
-
r
ATP + CDP
ADP + CTP
-
-
-
-
?
ATP + CDP
ADP + CTP
-
outer mitochondrial membrane-bound NDPK activity is involved in functional coupling to oxidative phosphorylation
-
-
?
ATP + CDP
ADP + CTP
-
highly effective dinucleotide substrate
-
-
?
ATP + CDP
ADP + CTP
-
-
-
r
ATP + CDP
ADP + CTP
-
reaction at 92% the rate of UDP
-
-
?
ATP + CDP
ADP + CTP
-
-
-
-
?
ATP + CDP
ADP + CTP
-
-
-
-
?
ATP + CDP
ADP + CTP
-
-
-
-
?
ATP + dADP
ADP + dATP
-
-
-
?
ATP + dADP
ADP + dATP
-
less effective dinucleotide substrate
-
-
?
ATP + dADP
ADP + dATP
-
-
-
r
ATP + dADP
ADP + dATP
-
reaction at 59% the rate of UDP
-
-
?
ATP + dCDP
ADP + dCTP
-
-
-
-
?
ATP + dCDP
ADP + dCTP
-
-
-
?
ATP + dCDP
ADP + dCTP
-
-
-
-
?
ATP + dCDP
ADP + dCTP
-
-
-
r
ATP + dCDP
ADP + dCTP
-
-
-
?
ATP + dCDP
ADP + dCTP
-
-
-
-
r
ATP + dCDP
ADP + dCTP
-
less effective dinucleotide substrate
-
-
?
ATP + dCDP
ADP + dCTP
-
-
-
r
ATP + dCDP
ADP + dCTP
-
reaction at 61% the rate of UDP
-
-
?
ATP + dGDP
ADP + dGTP
-
-
-
?
ATP + dGDP
ADP + dGTP
-
-
-
r
ATP + dGDP
ADP + dGTP
dGDP is preferred over dTDP as an acceptor
-
-
?
ATP + dGDP
ADP + dGTP
-
-
-
-
r
ATP + dGDP
ADP + dGTP
-
less effective dinucleotide substrate
-
?
ATP + dGDP
ADP + dGTP
-
-
-
r
ATP + dGDP
ADP + dGTP
-
reaction at 55% the rate of UDP
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
?
ATP + dTDP
ADP + dTTP
-
in decreasing order of activity: UDP, dUDP, dCDP, GDP, dGDP, CDP
-
-
?
ATP + dTDP
ADP + dTTP
-
GTP can fully replace ATP
-
-
?
ATP + dTDP
ADP + dTTP
-
best substrate: dTDP
-
-
?
ATP + dTDP
ADP + dTTP
-
in decreasing order of activity: dGDP, IDP, UDP, dUDP, CDP, GDP, dCDP
-
?
ATP + dTDP
ADP + dTTP
-
best substrate: dTDP
-
?
ATP + dTDP
ADP + dTTP
-
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
r
ATP + dTDP
ADP + dTTP
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
-
r
ATP + dTDP
ADP + dTTP
-
highly effective dinucleotide substrate
-
?
ATP + dTDP
ADP + dTTP
-
reaction at 27% the rate of UDP
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
?
ATP + dTDP
ADP + dTTP
-
-
-
r
ATP + dTDP
ADP + dTTP
-
-
-
-
?
ATP + dUDP
?
-
highly effective dinucleotide substrate
-
-
?
ATP + dUDP
?
-
reaction at 39% the rate of UDP
-
-
?
ATP + dUDP
ADP + dUTP
-
-
-
-
?
ATP + dUDP
ADP + dUTP
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
r
ATP + GDP
ADP + GTP
-
-
-
-
?
ATP + GDP
ADP + GTP
assay by spontaneous release of GDP from G proteins. This GDP serves as a substrate for phosphotransfer by the NDPK, and the formed GTP then binds back to the G protein. NDPK is able to transfer phosphate also onto denatured proteins and thus also on the covalently linked GDP
-
-
r
ATP + GDP
ADP + GTP
-
-
-
-
r
ATP + GDP
ADP + GTP
-
-
-
-
r
ATP + GDP
ADP + GTP
-
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
-
r
ATP + GDP
ADP + GTP
-
-
-
-
r
ATP + GDP
ADP + GTP
-
-
-
-
r
ATP + GDP
ADP + GTP
-
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
-
r
ATP + GDP
ADP + GTP
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
-
?
ATP + GDP
ADP + GTP
-
an essential function of NDP kinase in ROS is phosphorylation of GDP to GTP, which is crucial for providing the functional cycle of transducin independently of its activation
-
-
?
ATP + GDP
ADP + GTP
-
assay by spontaneous release of GDP from G proteins. This GDP serves as a substrate for phosphotransfer by the NDPK, and the formed GTP then binds back to the G protein. NDPK is able to transfer phosphate also onto denatured proteins and thus also on the covalently linked GDP
-
-
r
ATP + GDP
ADP + GTP
-
-
-
-
?
ATP + GDP
ADP + GTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, enzyme is able to specifically interact with proteins encoded by the bacteriophage T4
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, NM23 metastasis suppressor involved in inactivation of oncogenic forms of Ras proteins
-
-
?
ATP + NDP
ADP + NTP
MgATP promotes correct folding and association
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, excreted enzyme enters the nucleus of HeLa and COS-1 cells and nicks chromosomal DNA in situ
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, extracellular enzyme contributes to ATP-induced cell death of macrophages
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, extracellular enzyme contributes to ATP-induced cell death of macrophages
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, excreted enzyme enters the nucleus of HeLa and COS-1 cells and nicks chromosomal DNA in situ
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
r
ATP + NDP
ADP + NTP
-
-
-
-
r
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, involved in coleoptile elongation and anaerobic stress response
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
r
ATP + NDP
ADP + NTP
-
-
-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, broad substrate specificity, in plants involved in different signaling pathways
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
-
-
-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
-
-
?
ATP + NDP
ADP + NTP
-
-
-
?
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
-
-
-
-
r
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
-
analysis of ATP binding by the enzyme at different concentrations and pH values, overview
-
-
r
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
-
-
-
r
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
this reaction is a reversible phosphate transfer to both ribonucleoside and deoxyribonucleoside diphosphates using NTP as a phosphate donor to provide adequate nucleosides for RNA or DNA synthesis
-
-
r
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
-
-
-
?
ATP + TDP
ADP + TTP
-
-
-
?
ATP + TDP
ADP + TTP
-
-
-
?
ATP + TDP
ADP + TTP
-
-
-
r
ATP + TDP
ADP + TTP
-
-
-
-
?
ATP + TDP
ADP + TTP
-
-
-
r
ATP + TDP
ADP + TTP
the enzyme activity depends largely upon the membrane-bound state
-
-
r
ATP + TDP
ADP + TTP
-
-
-
-
r
ATP + TDP
ADP + TTP
-
-
-
-
?
ATP + TDP
ADP + TTP
-
-
-
-
r
ATP + TDP
ADP + TTP
-
-
-
-
r
ATP + TDP
ADP + TTP
-
the enzyme activity depends largely upon the membrane-bound state
-
-
r
ATP + TDP
ADP + TTP
-
-
-
?
ATP + UDP
ADP + UTP
-
-
-
-
?
ATP + UDP
ADP + UTP
-
-
-
?
ATP + UDP
ADP + UTP
-
-
-
r
ATP + UDP
ADP + UTP
NDPK regulates a variety of eukaryotic cellular activities including cell proliferation, development, and differentiation
-
-
r
ATP + UDP
ADP + UTP
-
reverse reaction at 32% the rate of the reaction ATP plus ADP
-
r
ATP + UDP
ADP + UTP
-
-
-
-
r
ATP + UDP
ADP + UTP
-
-
-
-
r
ATP + UDP
ADP + UTP
-
-
-
-
r
ATP + UDP
ADP + UTP
-
-
-
-
r
ATP + UDP
ADP + UTP
-
-
-
-
?
ATP + UDP
ADP + UTP
-
highly effective dinucleotide substrate
-
-
?
ATP + UDP
ADP + UTP
-
-
-
?
ATP + UDP
ADP + UTP
-
best dinucleotide substrate
-
r
ATP + UDP
ADP + UTP
-
-
-
?
ATP + UDP
ADP + UTP
-
-
-
-
?
CTP + CDP
CDP + CTP
-
reaction at 15% the rate of ATP
-
?
CTP + CDP
CDP + CTP
-
-
-
?
dATP + ADP
dADP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dATP + ADP
dADP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dCTP + ADP
dCDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dCTP + ADP
dCDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dGTP + ADP
dGDP + ATP
-
-
-
-
?
dGTP + ADP
dGDP + ATP
the wild-type enzyme is not active when using dGTP as the phosphate donor. The Pyrobaculum aerophilum NDP kinase sequence contains two unique segments not present in other NDP kinases, comprising residues 66100 and 156165. Deletion mutants of the NDP kinase lacking either or both of these inserts have an altered substrate specificity, allowing dGTP as the phosphate donor
-
-
?
dGTP + ADP
dGDP + ATP
the wild-type enzyme is not active when using dGTP as the phosphate donor. The Pyrobaculum aerophilum NDP kinase sequence contains two unique segments not present in other NDP kinases, comprising residues 66100 and 156165. Deletion mutants of the NDP kinase lacking either or both of these inserts have an altered substrate specificity, allowing dGTP as the phosphate donor
-
-
?
dTTP + ADP
dTDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
dTTP + ADP
dTDP + ATP
at 25°C, the wild-type enzyme has the highest affinity for dCTP, followed by dATP, and then dTTP. dCTP is the best phosphate donor at both 25°C and 50°C
-
-
?
gamma-S-ATP + GDP
ADP + gamma-S-GTP
-
poor substrate
-
-
?
gamma-S-ATP + GDP
ADP + gamma-S-GTP
-
poor substrate
-
-
?
gamma-S-ATP + GDP
ADP + gamma-S-GTP
-
poor substrate
-
-
?
gamma-S-GTP + GDP
GDP + gamma-S-GTP
-
poor substrate
-
-
?
gamma-S-GTP + GDP
GDP + gamma-S-GTP
-
poor substrate
-
-
?
gamma-S-GTP + GDP
GDP + gamma-S-GTP
-
poor substrate
-
-
?
GTP + ADP
GDP + ATP
-
-
-
-
?
GTP + ADP
GDP + ATP
-
-
-
-
?
GTP + ADP
GDP + ATP
-
reaction at 12% the rate of ATP
-
-
?
GTP + ADP
GDP + ATP
-
dADP can replace ADP
-
r
GTP + ADP
GDP + ATP
-
-
-
?
GTP + ADP
GDP + ATP
-
-
-
-
?
GTP + ADP
GDP + ATP
-
-
-
r
GTP + ADP
GDP + ATP
-
GDP is less effective dinucleotide substrate
-
r
GTP + ADP
GDP + ATP
-
-
-
r
GTP + ADP
GDP + ATP
-
-
-
r
GTP + ADP
GDP + ATP
-
reverse reaction at 62% the rate of UDP
-
r
GTP + ADP
GDP + ATP
-
-
-
r
GTP + ADP
GDP + ATP
-
-
-
r
GTP + ADP
GDP + ATP
-
-
-
r
GTP + ADP
GDP + ATP
-
-
-
r
GTP + CDP
GDP + CTP
-
-
-
-
?
GTP + CDP
GDP + CTP
-
-
-
r
GTP + GDP
GDP + GTP
-
in decreasing order of activity: UTP, dGTP, dTTP, CTP, dCTP, dUTP
-
?
GTP + GDP
GDP + GTP
-
equally active as ATP
-
?
GTP + GDP
GDP + GTP
-
-
-
?
GTP + NDP
GDP + NTP
-
-
-
-
?
GTP + NDP
GDP + NTP
-
-
-
-
?
GTP + nucleoside diphosphate
GDP + nucleoside triphosphate
-
-
-
-
?
GTP + nucleoside diphosphate
GDP + nucleoside triphosphate
-
-
-
-
?
GTP + nucleoside diphosphate
GDP + nucleoside triphosphate
-
-
-
-
?
GTP + UDP
GDP + UTP
-
-
-
-
?
GTP + UDP
GDP + UTP
-
-
-
-
?
ITP + ADP
IDP + ATP
-
-
-
?
ITP + ADP
IDP + ATP
-
reverse reaction at 42% the rate of UDP
-
?
ITP + ADP
IDP + ATP
-
-
-
?
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
may be involved in regulation of growth, development and signal-transduction processes
-
-
?
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
enzyme forms complexes with G protein beta gamma dimers and contributes to G protein activation
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
-
-
-
r
NDP + NTP
NTP + NDP
-
overview on roles in metabolic pathways and nucleic acid synthesis
-
-
?
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
Impatiens holstii
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
major component of nucleoside triphosphate synthetic pathway
-
-
?
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
involved in RNA- and DNA metabolism
-
-
?
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
-
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
autophosphorylation and phosphorylation of histone H1
-
-
?
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NDP + NTP
NTP + NDP
-
overview: functions in the cell
-
-
r
NTP + NDP
NDP + NTP
-
-
-
r
NTP + NDP
NDP + NTP
NDPK is a key metabolic enzyme that catalyzes the synthesis of non-adenine nucleoside triphosphate by transferring the terminal phosphate between NDP and NTP
-
-
r
NTP + NDP
NDP + NTP
-
-
-
r
NTP + NDP
NDP + NTP
the high-energy phosphate is mainly supplied by ATP, but the enzymes have broad substrate specificity and use the ribose and deoxyribose forms of both, purine and pyrimidine nucleotides, ping-pong mechanism with a phosphoenzyme/phosphohistidine intermediary involved in the transfer reaction, overview
-
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
no substrates are several nucleoside monophosphates
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the nature of the nucleoside triphosphate controls the rate of the reaction
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate 8-aza-UDP, human erythrocytic pI-variant 5.8
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
Impatiens holstii
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
in decreasing order of activity: UTP, dTTP, CTP, dATP, ATP, dGTP, GTP
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
-
-
-
?
NTP + nucleoside diphosphate
NDP + NTP
-
broad specificity
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrate: 5-fluoro-UTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
trinucleotide substrates: ATP, CTP, GTP, ITP, dTTP, UTP, dCTP, dGTP
-
r
NTP + nucleoside diphosphate
NDP + NTP
-
substrates: 6-aza-UDP, 8-aza-GDP
-
r
NTP + nucleoside diphosphate
NDP + NTP
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the broad specificity may reflect the presence of mixtures of isozymes of different reactivities with nucleotide substrates
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r
NTP + nucleoside diphosphate
NDP + NTP
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transfers gamma-phosphate from NTP to any nucleoside diphosphate
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r
NTP + nucleoside diphosphate
NDP + NTP
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dinucleotide substrates: ADP, CDP, GDP, UDP, IDP, dCDP, dGDP, dTDP
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r
NTP + nucleoside diphosphate
NDP + NTP
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broad specificity
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?
NTP + nucleoside diphosphate
NDP + NTP
-
many ribo- and deoxyribonucleoside triphosphates act as donors
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?
NTP + nucleoside diphosphate
NDP + NTP
-
transfers gamma-phosphate from NTP to any nucleoside diphosphate
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?
UTP + CDP
UDP + CTP
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best substrate: UTP
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?
UTP + CDP
UDP + CTP
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in decreasing order of activity: dATP, ITP, dTTP, ATP, dGTP, GTP, dCTP, CTP
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?
UTP + CDP
UDP + CTP
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-
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?
UTP + dCDP
UDP + dCTP
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best substrate: UTP
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-
?
UTP + dCDP
UDP + dCTP
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in decreasing order of activity: ITP, dATP, dTTP, dGTP, GTP, ATP, CTP, dCTP
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?
UTP + dCDP
UDP + dCTP
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-
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?
UTP + dTDP
UDP + dTDP
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best substrate: UTP
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-
?
UTP + dTDP
UDP + dTDP
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in decreasing order of activity: ITP, dATP, dTTP, GTP, ATP, dGTP, dUTP, CTP, dCTP
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-
?
UTP + dTDP
UDP + dTDP
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best substrates
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-
?
UTP + dTDP
UDP + dTDP
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nucleoside triphosphates in decreasing order of activity: dTTP, CTP, dCTP, dATP, dGTP, GTP
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-
?
UTP + dTDP
UDP + dTDP
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nucleoside diphosphates in decreasing order of activity: CDP, UDP, GDP, dGDP, dCDP, dADP, ADP
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?
additional information
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role of enzyme in dUTP detoxification to compensate for the absence of a dUTPase in Mimivirus
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?
additional information
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preferential affinity for deoxypyrimidine nucleotides
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?
additional information
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the enzyme catalyzes transfer of the gamma-phosphate from a nucleoside triphosphate (NTP) to a nucleoside diphosphate (NDP)
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?
additional information
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NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
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?
additional information
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NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
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?
additional information
?
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-
NDPK2 is a H2O2 signaling protein that performs autophosphorylation. NDPK2 and H2O2 are involved in salt resistance, overview
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?
additional information
?
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nucleoside diphosphate kinase is a housekeeping enzyme that maintains the intracellular levels of all (d)NTPs used in biosynthesis except ATP, but it also plays a significant role in signal transduction pathways involved in oxidative stress. The enzyme protects the plants against reactive ocygen species, heat, and salt stress, overview
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?
additional information
?
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-
NDPK2 interacts with plant small G proteins in vitro, both Pra2 and Pra3both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
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-
?
additional information
?
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NDPK2 interacts with plant small G proteins in vitro, both Pra2 and Pra3both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
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-
?
additional information
?
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adenine nucleosides are used preferentially compared to cytidine nucleosides
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-
-
additional information
?
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adenine nucleosides are used preferentially compared to cytidine nucleosides
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-
-
additional information
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adenine nucleosides are used preferentially compared to cytidine nucleosides
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-
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additional information
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the enzyme's primary function is to maintain dNTP pools by converting deoxynucleotide diphosphates to triphosphates using ATP as the major phosphate donor
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?
additional information
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the enzyme's primary function is to maintain dNTP pools by converting deoxynucleotide diphosphates to triphosphates using ATP as the major phosphate donor
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?
additional information
?
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strong preference for D-enantiomers of antiviral nucleotide analogs like ddATP, ddCTP, 3'-deoxy-3'-thymidine, 2',3'-didehydro-2',3'-dideoxythymidine
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-
?
additional information
?
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binding affinity of NDPs with the recombinant enzyme measured by isothermal titration calorimetry, indicate that the purines nucleotides show higher binding affinity compared with pyrimidines. The recombinant enzyme rNDPK has a definite nuclease activity in vitro, which cleaves supercoiled plasmid DNA, but has no effect on dsDNA and ssDNA. No or poor activity with CDP and UDP
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-
?
additional information
?
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binding affinity of NDPs with the recombinant enzyme measured by isothermal titration calorimetry, indicate that the purines nucleotides show higher binding affinity compared with pyrimidines. The recombinant enzyme rNDPK has a definite nuclease activity in vitro, which cleaves supercoiled plasmid DNA, but has no effect on dsDNA and ssDNA. No or poor activity with CDP and UDP
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-
?
additional information
?
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-
NDPK catalyzes the transfer of gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates
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-
?
additional information
?
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substrate specificities of wild-type and G114R mutant enzymes, overview
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?
additional information
?
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critical role of the two amino acid residues, E134 and E135, at the carboxy-terminal region of NDK in determining the halophilic characteristics of the protein, overview
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?
additional information
?
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in the absence of nucleoside diphosphates the enzyme undergoes Mg2+-dependent stoichiometric autophosphorylation using ATP, GTP or gamma-thiotriphosphate as phosphate donor, 2 mol phosphate per mol enzyme
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?
additional information
?
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-
MDA-MB-435S cell-secreted NDPK-B supports tumour formation by modulating ATP levels locally to activate endothelial cell P2Y receptor-mediated angiogenesis, overview
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?
additional information
?
-
NDPKA is a housekeeping enzyme essential for the synthesis of nonadenine nucleoside and deoxynucleoside 5'-triphosphate
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?
additional information
?
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NDPKA is a housekeeping enzyme essential for the synthesis of nonadenine nucleoside and deoxynucleoside 5'-triphosphate
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?
additional information
?
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the enzyme catalyzes transfer of the gamma-phosphate from a nucleoside triphosphate, NTP, to a nucleoside diphosphate, NDP
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?
additional information
?
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the transfer of high energetic phosphate by NDPK and/or the beta subunit of G proteins can induce G protein activation. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers influencing the G protein activation and stability, mechanism, detailed overview
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?
additional information
?
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NDPK B acts as histidine kinase in a NDPK B/Gbetagamma complex, NDPK B/Gbetagamma complex formation, structure, and mode of action, overview. Nucleoside diphosphate kinase is a ubiquitous enzyme that catalyses the transfer of the gamma-phosphate from nucleoside 5'-triphosphates to nucleoside 5'-diphosphates by a ping-pong mechanism involving the formation of a high energy phosphate intermediate on His118
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?
additional information
?
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NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways
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?
additional information
?
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isoform NDPK-D is able to bind in a non-negligible manner to zwitterionic phosphatidylcholine
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?
additional information
?
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nucleoside diphosphate kinase B forms a functional complex with cell surface CFTR, binding analysis using peptide NDPK-B 36-54 (V36AMKFLRAS44EEHLKQHYID54), this region of NDPK-B, may constitute a key NDPK-B interaction domain for CFTR, the nucleotide binding domain 1 (NBD1, aa 351-727) of CFTR constitutes an NDPK-B interaction site with CFTR, surface plasmon resonance and NDPK-B and NBD1 protein-protein docking analysis
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?
additional information
?
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NdK is a stable enzyme capable of decreasing extracellular ATP levels
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?
additional information
?
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both recombinant and native Leishmania NdK utilized ATP to produce expected nucleoside triphosphates in the presence of nucleoside diphosphates in excess
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?
additional information
?
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NdK is a stable enzyme capable of decreasing extracellular ATP levels
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?
additional information
?
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both recombinant and native Leishmania NdK utilized ATP to produce expected nucleoside triphosphates in the presence of nucleoside diphosphates in excess
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?
additional information
?
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in the absence of nucleoside diphosphates the enzyme undergoes Mg2+-dependent stoichiometric autophosphorylation using ATP, GTP or gamma-thiotriphosphate as phosphate donor, 2 mol phosphate per mol enzyme
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-
?
additional information
?
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-
NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways
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-
?
additional information
?
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catalyzes cleavage of single strand DNA, oligonucleotide P1 used for experiments
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?
additional information
?
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catalyzes cleavage of single strand DNA, oligonucleotide P1 used for experiments
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-
?
additional information
?
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the enzyme binds to and inactivates the small GTPase Rac1 in the macrophage. This results in the exclusion of the Rac1 binding partner p67phox from phagosomes containing bacteria- or enzyme-coated latex beads. Exclusion of p67phox is associated with a defect of both NOX2 assembly and production of reactive oxygen species in response to wild-type bacteria
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-
?
additional information
?
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catalyzes cleavage of single strand DNA, oligonucleotide P1 used for experiments
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-
?
additional information
?
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NDK-1 plays an important role in protecting conidial viability under light stress in Neurospora crassa
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?
additional information
?
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NDK-1 plays an important role in protecting conidial viability under light stress in Neurospora crassa
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?
additional information
?
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NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways
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-
?
additional information
?
-
enzyme LvNDK has relaxed substrate specificity and binds both purine and pyrimidine deoxynucleoside diphosphates with high binding affinity for dGDP and dADP and with low binding interaction for dCDP. The binding of deoxy- or ribonucleotides is similar, as in the former a water molecule replaces the hydrogen bond made by Lys11 to the 20-hydroxyl group of the ribose moiety. This allows Lys11 to maintain a catalytically favourable conformation independently of the kind of sugar found in the nucleotide
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?
additional information
?
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enzyme LvNDK has relaxed substrate specificity and binds both purine and pyrimidine deoxynucleoside diphosphates with high binding affinity for dGDP and dADP and with low binding interaction for dCDP. The binding of deoxy- or ribonucleotides is similar, as in the former a water molecule replaces the hydrogen bond made by Lys11 to the 20-hydroxyl group of the ribose moiety. This allows Lys11 to maintain a catalytically favourable conformation independently of the kind of sugar found in the nucleotide
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?
additional information
?
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enzyme additionally has nuclease activity cleaving supercoiled plasmid DNA, tRNAs or the 3UTR of atp9 mRNA. Nuclease- and kinase mechanisms are separate
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?
additional information
?
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key enzyme involved in the homeostasis of nucleoside triphosphates
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?
additional information
?
-
key enzyme involved in the homeostasis of nucleoside triphosphates
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?
additional information
?
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nucleoside diphosphate kinase is responsible for maintaining the nucleotide balance in the cell, but is also involved in regulatory functions that often are mediated via protein-protein interactions, differentially for adenylate kinase isozymes, overview
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?
additional information
?
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NDPK3 protein additionally cleaves not only supercoiled plasmid DNA, but also highly structured RNA molecules such as tRNAs or the 3'UTR of the atp9 mRNA suggesting that the NDPK3 nuclease activity has a structural requirement, ATP inhibits this nuclease activity, while ADP has no effect, the nuclease- and the kinase-mechanisms are separate, overview
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?
additional information
?
-
-
protein-protein interaction analysis of adenylate kinases from Arabidopsis thaliana with the immobilized recombinant His-tagged NDPK from Pisum sativum, the interaction influences both enzyme activities, overview
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?
additional information
?
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the binding affinity of different nucleotides with Plasmodium falciparum nucleoside diphosphate kinase is varied according to the following order ADP/GDP > dGDP > dADP > dTDP > CDP > dCDP >U DP. The enzyme shows more preferences to ribonucleotides over deoxyribonucleotides
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?
additional information
?
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coupling of the formation of ATP to phenazine methosulfate and iodonitrotetrazolium chloride, coupling is achieved using hexokinase and G6PDH, which produce the necessary NADPH molecules for formazan precipitation at the site of enzyme activity, method optimization, overview, measurement of the reverse enzyme reactions, overview
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?
additional information
?
-
-
in the absence of nucleoside diphosphates the enzyme undergoes Mg2+-dependent stoichiometric autophosphorylation using ATP, GTP or gamma-thiotriphosphate as phosphate donor, 2 mol phosphate per mol enzyme
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-
?
additional information
?
-
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enzyme is involved in receptor-independent regulation of cAMP synthesis and contractility in intact cardiomyocytes and has histidine kinase activity for phosphorylation of G protein subunit beta phosphorylation at H266
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?
additional information
?
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In addition to the receptor-induced GDP/GTP exchange, G protein alpha subunits can be activated by a phosphate transfer via a plasma membrane-associated complex of NDPK B and G protein betagamma-dimers, Gbetagamma, requiring the intermediate phosphorylation of His266, the histidine kinase activity of NDPK B for Gbeta is important for the receptor-independent regulation of cAMP synthesis and contractility in intact cardiomyocytes, overview
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?
additional information
?
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the enzyme is involved in endoplasmic reticulum membranes structure formation, the mechanism of membrane extension involves direct lipid binding, as NDKB-bound phosphatidylinositol-4-phosphate, phosphatidylinositol-4,5-diphosphate, and phosphatidic acid. Binding to these anionic lipids requires clusters of basic residues on the surface of the NDKB hexamer. Amino acid changes in NDKB, that block lipid binding, also block endoplasmic reticulum network extension, overview
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?
additional information
?
-
-
the transfer of high energetic phosphate by NDPK and/or the beta subunit of G proteins can induce G protein activation. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers influencing the G protein activation and stability, mechanism, detailed overview
-
-
?
additional information
?
-
-
interaction of recombinant NDP kinases alpha and beta and their mutant chimeric derivatives with rhodopsin-transducin complex, binding to ROS photoreceptor membranes, overview
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-
?
additional information
?
-
-
NDKB stabilizes an extended endoplasmic reticulum network in vitro, overview
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-
?
additional information
?
-
-
NDPK B acts as histidine kinase in a NDPK B/Gbetagamma complex, NDPK B/Gbetagamma complex formation, structure, and mode of action, overview. Nucleoside diphosphate kinase is a ubiquitous enzyme that catalyses the transfer of the gamma-phosphate from nucleoside 5'-triphosphates to nucleoside 5'-diphosphates by a ping-pong mechanism involving the formation of a high energy phosphate intermediate on His118
-
-
?
additional information
?
-
-
autophosphorylation and phosphorylation of histone H1
-
-
?
additional information
?
-
NDPK1 exhibits nuclease activity cleaving not only linear DNA, but also supercoiled plasmid DNA, ATP or ADP do not affect the nuclease activity while the absence of Mg2+ completely inhibits this activity
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-
?
additional information
?
-
NDPK1 exhibits nuclease activity cleaving not only linear DNA, but also supercoiled plasmid DNA, ATP or ADP do not affect the nuclease activity while the absence of Mg2+ completely inhibits this activity
-
-
?
additional information
?
-
-
NDPK1 exhibits nuclease activity cleaving not only linear DNA, but also supercoiled plasmid DNA, ATP or ADP do not affect the nuclease activity while the absence of Mg2+ completely inhibits this activity
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-
?
additional information
?
-
the enzyme has nuclease activity and DNA-binding properties in vitro
-
-
-
additional information
?
-
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the enzyme has nuclease activity and DNA-binding properties in vitro
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-
-
additional information
?
-
the enzyme has nuclease activity and DNA-binding properties in vitro
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-
-
additional information
?
-
kinetic parameters and regulation mechanisms of NDPK1 and NDPK2, overview
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?
additional information
?
-
-
sequential ordered bi-bi reaction mechanism. The enzyme additionally shows dTMP kinase activity, reaction of EC 2.7.4.9, using dTMP as a substrate to produce dTDP
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?