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2.7.4.6: nucleoside-diphosphate kinase

This is an abbreviated version!
For detailed information about nucleoside-diphosphate kinase, go to the full flat file.

Word Map on EC 2.7.4.6

Reaction

ATP
+
nucleoside diphosphate
=
ADP
 +
nucleoside triphosphate

Synonyms

AfNDK, Afu5g03490, ASNDK, At4g09320, At4g11010, At5g63310, HsNDK, kinase, nucleoside diphosphate (phosphorylating), mitochondrial nucleoside diphosphate kinase, MJ1265, More, NDK, NDK B, NDK-1, NDKB, NDP kinase, NDP kinase A, NDP kinase alpha, NDP kinase beta, NDPK, NDPK B, NDPK I, NDPK II, NDPK III, NDPK IIpn, NDPK In, NDPK-3, NDPK-B, NDPK-C, NDPK-D, NDPK-In, NDPK1, NDPK2, NDPK3, NDPK3a, NDPKA, NDPKB, NM23, NM23 metastasis suppressor, Nm23-H1, NM23-H2, NM23-H4, NME1, NME2, NME3, NME4, nucleoside 5'-diphosphate kinase, nucleoside diphosphate (UDP) kinase, nucleoside diphosphate kinase, nucleoside diphosphate kinase 1, nucleoside diphosphate kinase 2, nucleoside diphosphate kinase 3, nucleoside diphosphate kinase 3a, nucleoside diphosphate kinase A, nucleoside diphosphate kinase B, nucleoside diphosphate kinase C, nucleoside diphosphate kinase D, nucleoside diphosphate kinase-1, nucleoside diphosphate kinase-2, nucleoside diphosphate kinases alpha, nucleoside diphosphate kinases beta, nucleoside diphosphate phosphotransferase, nucleoside diphosphokinase, nucleoside-diphosphate kinase 3, nucleotide diphosphate kinase, nucleotide phosphate kinase, ORF454, Os12g36194, OsNDPK2, SwoH, TcNDPK1, TcNDPK3, UDP kinase, uridine diphosphate kinase, WSL12, YSS2 protein

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.6 nucleoside-diphosphate kinase

Specific Activity

Specific Activity on EC 2.7.4.6 - nucleoside-diphosphate kinase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000083
-
autophosphorylation assay
1000
about, in absence of NaCl, purified wild-type enzyme
103.5
line R3-1 isoform NDPK3, using dTDP as substrate, at pH 7.5 and 22°C
1100
-
about, in absence of NaCl, purified wild-type enzyme
112.6
wild type isoform NDPK3, using dTDP as substrate, at pH 7.5 and 22°C
12.1
pH and temperature not specified in the publication, NDPK1
1250
-
NDP-kinase I, 37°C, pH 7.4
156.6
wild type isoform NDPK2, using dGDP as substrate, at pH 7.5 and 22°C
160
S69A mutant enzyme with dCDP as substrate, 22°C
1736
-
30°C, pH 8.0
2026
-
25°C
207
-
purified extracellular enzyme
2160
-
NDP-kinase II, 37°C, pH 7.4
2400
S119A mutant enzyme with dCDP as substrate, 22°C
2700
wild type enzyme with dCDP as substrate, 22°C
283.9
line R3-1 isoform NDPK2, using dGDP as substrate, at pH 7.5 and 22°C
340
pH 8.0, temperature not specified in the publication
360
-
25°C, pH 8.0
3900
S119A mutant enzyme with dTDP as substrate, 22°C
41.3
wild type isoform NDPK2, using dTDP as substrate, at pH 7.5 and 22°C
4341
pH 7.5, 30°C
5.4
-
37°C, pH 7.6
50
H117A mutant enzyme with dCDP as substrate, 22°C
5100
wild type enzyme with dTDP as substrate, 22°C
550
-
isozyme A6, 25°C
60
S69A/S119A mutant enzyme with dCDP as substrate, 22°C
63.98
line R3-1 isoform NDPK3, using dGDP as substrate, at pH 7.5 and 22°C
64.43
wild type isoform NDPK3, using dGDP as substrate, at pH 7.5 and 22°C
6427
-
purified cytosolic enzyme
70
H117D/S119A mutant enzyme with dCDP as substrate, 22°C
700
S69A mutant enzyme with dTDP as substrate, 22°C
740
-
isozyme B6, 25°C
90.55
line R3-1 isoform NDPK2, using dTDP as substrate, at pH 7.5 and 22°C
additional information