2.7.4.6: nucleoside-diphosphate kinase This is an abbreviated version! For detailed information about nucleoside-diphosphate kinase, go to the full flat file .
Reaction
ATP +
nucleoside diphosphate =
ADP +
nucleoside triphosphate
Synonyms AfNDK, Afu5g03490, ASNDK, At4g09320, At4g11010, At5g63310, HsNDK, kinase, nucleoside diphosphate (phosphorylating), mitochondrial nucleoside diphosphate kinase, MJ1265, More, NDK, NDK B, NDK-1, NDKB, NDP kinase, NDP kinase A, NDP kinase alpha, NDP kinase beta, NDPK, NDPK B, NDPK I, NDPK II, NDPK III, NDPK IIpn, NDPK In, NDPK-3, NDPK-B, NDPK-C, NDPK-D, NDPK-In, NDPK1, NDPK2, NDPK3, NDPK3a, NDPKA, NDPKB, NM23, NM23 metastasis suppressor, Nm23-H1, NM23-H2, NM23-H4, NME1, NME2, NME3, NME4, nucleoside 5'-diphosphate kinase, nucleoside diphosphate (UDP) kinase, nucleoside diphosphate kinase, nucleoside diphosphate kinase 1, nucleoside diphosphate kinase 2, nucleoside diphosphate kinase 3, nucleoside diphosphate kinase 3a, nucleoside diphosphate kinase A, nucleoside diphosphate kinase B, nucleoside diphosphate kinase C, nucleoside diphosphate kinase D, nucleoside diphosphate kinase-1, nucleoside diphosphate kinase-2, nucleoside diphosphate kinases alpha, nucleoside diphosphate kinases beta, nucleoside diphosphate phosphotransferase, nucleoside diphosphokinase, nucleoside-diphosphate kinase 3, nucleotide diphosphate kinase, nucleotide phosphate kinase, ORF454, Os12g36194, OsNDPK2, SwoH, TcNDPK1, TcNDPK3, UDP kinase, uridine diphosphate kinase, WSL12, YSS2 protein
ECTree
Source Tissue
Source Tissue on EC 2.7.4.6 - nucleoside-diphosphate kinase
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located in the epidermis of the branchial crown
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intermediate expression
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highly expressed in cotyledons of seedlings
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moderate expression
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located in the epidermis of the branchial crown
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Ndk-3 is expressed relatively equally in all tissues with higher transcript abundance in either Malpighian tubules or fat bodies in 24 or 48 h larvae
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the expression level is increased in hemolymph after bacterial challenge
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in hepatocarcinoma derived cell lines, NME4 expression is lower in cell lines with high metastatic potential
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Novikoff
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low activity
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aerial hyphae, presence of enzyme during most developmental stages
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highest transcript abundance of Ndk-1 at 24 h old larvae
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low expression
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low activity
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Ndk-2, it exhibits highest transcript abundance in Malpighian tubules and is expressed in very low levels in other tissues including salivary glands
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of the mucosa, RBL-2H3 cell line
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highly expressed in meristems and provascular tissues
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Ndk-3 is expressed relatively equally in all tissues with higher transcript abundance in either Malpighian tubules or fat bodies in 24 or 48 h larvae
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mast cell, cell line RBL-2H3
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intermediate expression
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WSL12 is highly expressed in young tissues
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presence of enzyme during most developmental stages
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companion cells
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isoforms A,B in the ratio 1:3
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high expression
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maximum levels of NDPK1 expression are found in procambium cells while expression of genes for other isoforms are either absent
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highest expression
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high expression
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highest transcript abundance of Ndk-2 in salivary glands in both 24 h and 48 h old larvae
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S2 cell
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immature seed
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intermediate expression
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high expression
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low expression
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pole pericycle
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highest expression
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high expression
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low expression
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H50-7209 cell suspension culture
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enzyme activity and protein level raise during exponential growth, no rise in activity when supply with sucrose is limited
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asexual conidia, presence of enzyme during most developmental stages
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isoforms A,B in the ratio 1:1
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increased expression during flower maturation
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low activity
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intermediate expression
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much lower NME4 mRNA level than the NME1 and NME2 counterparts
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the expression level is increased in hemocytes after bacterial challenge
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high activity
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moderate expression
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intermediate expression
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low activity
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highest expression
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high expression
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much lower NME4 mRNA level than the NME1 and NME2 counterparts
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cortex
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Impatiens holstii
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highly expressed in leaves and young tissues
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WSL12 is highly expressed in young tissues
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high expression
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highest expression
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high expression
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much lower NME4 mRNA level than the NME1 and NME2 counterparts
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breast muscle
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moderate activity
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skeletal muscle
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skeletal muscle
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submerged mycelium, presence of enzyme during most developmental stages
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highly expressed in roots of seedlings
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WSL12 is highly expressed in young tissues
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predominant localization in meristematic zones and provascular tissues
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etiolated
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expression of NDK2 increases dramatically when seedlings germinated in the dark are transferred into light, not expressed when seedlings are grown in the dark
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increased expression at day 3-4 in seedlings germinated in the dark, highly expressed in hooks of seedlings
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increased expression from day 2-5 in seedlings germinated in the dark, highly expressed in hooks of seedlings
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i.e. Tobacco Bright Yellow 2 cells
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the isoenzyme form TcNDPK3 is found only in the bloodstream trypomastigotes. TcNDPK3 mRNA is also detected at lower levels in amastigotes suggesting regulation at protein and mRNA level
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the isoenzyme form TcNDPK3 is found only in the bloodstream trypomastigotes. TcNDPK3 mRNA is also detected at lower levels in amastigotes suggesting regulation at protein and mRNA level
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additional information
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NDPK1 is the most highly expressed isozyme, followed by isozymes NDPK3a and NDPK3b, the latter is generally expressed at very low extent but increased in inflorescences and dividing cells
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additional information
in situ hybridization
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additional information
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in situ hybridization
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additional information
HeLa cells are naturally almost devoid of NDPK-D
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additional information
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isoform NDPK1 is weakly expressed in leaf sheaths
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additional information
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tissue distribution
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