2.7.4.6: nucleoside-diphosphate kinase
This is an abbreviated version!
For detailed information about nucleoside-diphosphate kinase, go to the full flat file.
Word Map on EC 2.7.4.6
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2.7.4.6
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triphosphate
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node
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gdp
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lymph
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adenylate
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metastases
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tumour
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autophosphorylation
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colorectal
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oncogene
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drosophila
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guanine
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c-myc
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clinicopathological
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melanoma
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creatine
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dictyostelium
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hexameric
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gtp-binding
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discoideum
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non-metastatic
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gamma-phosphate
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anti-metastatic
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heterotrimeric
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phosphohistidine
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transphosphorylation
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dntp
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deoxyribonucleoside
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succinyl-coa
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phosphoenzyme
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metastasis-related
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mastoparan
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high-metastatic
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metastasis-associated
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prune
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c-erbb-2
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myxococcus
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g-quadruplexes
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deoxynucleoside
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xanthus
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medicine
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drug development
- 2.7.4.6
- triphosphate
- node
- gdp
- lymph
- adenylate
- metastases
- tumour
- autophosphorylation
- colorectal
- oncogene
- drosophila
- guanine
- c-myc
-
clinicopathological
- melanoma
- creatine
- dictyostelium
-
hexameric
-
gtp-binding
- discoideum
-
non-metastatic
-
gamma-phosphate
-
anti-metastatic
-
heterotrimeric
-
phosphohistidine
-
transphosphorylation
- dntp
- deoxyribonucleoside
- succinyl-coa
- phosphoenzyme
-
metastasis-related
- mastoparan
-
high-metastatic
-
metastasis-associated
-
prune
-
c-erbb-2
- myxococcus
-
g-quadruplexes
- deoxynucleoside
- xanthus
- medicine
- drug development
Reaction
Synonyms
AfNDK, Afu5g03490, ASNDK, At4g09320, At4g11010, At5g63310, HsNDK, kinase, nucleoside diphosphate (phosphorylating), mitochondrial nucleoside diphosphate kinase, MJ1265, More, NDK, NDK B, NDK-1, NDKB, NDP kinase, NDP kinase A, NDP kinase alpha, NDP kinase beta, NDPK, NDPK B, NDPK I, NDPK II, NDPK III, NDPK IIpn, NDPK In, NDPK-3, NDPK-B, NDPK-C, NDPK-D, NDPK-In, NDPK1, NDPK2, NDPK3, NDPK3a, NDPKA, NDPKB, NM23, NM23 metastasis suppressor, Nm23-H1, NM23-H2, NM23-H4, NME1, NME2, NME3, NME4, nucleoside 5'-diphosphate kinase, nucleoside diphosphate (UDP) kinase, nucleoside diphosphate kinase, nucleoside diphosphate kinase 1, nucleoside diphosphate kinase 2, nucleoside diphosphate kinase 3, nucleoside diphosphate kinase 3a, nucleoside diphosphate kinase A, nucleoside diphosphate kinase B, nucleoside diphosphate kinase C, nucleoside diphosphate kinase D, nucleoside diphosphate kinase-1, nucleoside diphosphate kinase-2, nucleoside diphosphate kinases alpha, nucleoside diphosphate kinases beta, nucleoside diphosphate phosphotransferase, nucleoside diphosphokinase, nucleoside-diphosphate kinase 3, nucleotide diphosphate kinase, nucleotide phosphate kinase, ORF454, Os12g36194, OsNDPK2, SwoH, TcNDPK1, TcNDPK3, UDP kinase, uridine diphosphate kinase, WSL12, YSS2 protein
ECTree
2.7.4.6 nucleoside-diphosphate kinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.4.6 - nucleoside-diphosphate kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + CDP
ADP + CTP
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outer mitochondrial membrane-bound NDPK activity is involved in functional coupling to oxidative phosphorylation
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-
?
ATP + UDP
ADP + UTP
NDPK regulates a variety of eukaryotic cellular activities including cell proliferation, development, and differentiation
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-
r
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
Mycobacterium tuberculosis H37Ra / ATCC 25177
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
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-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + dNDP
ADP + dNTP
contributes to the maintenance of the cellular pools of all deoxynucleoside triphosphates
-
-
?
ATP + GDP
ADP + GTP
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an essential function of NDP kinase in ROS is phosphorylation of GDP to GTP, which is crucial for providing the functional cycle of transducin independently of its activation
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-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
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-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
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-
?
ATP + NDP
ADP + NTP
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates, enzyme is able to specifically interact with proteins encoded by the bacteriophage T4
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-
?
ATP + NDP
ADP + NTP
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates
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-
?
ATP + NDP
ADP + NTP
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates
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-
?
ATP + NDP
ADP + NTP
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates, NM23 metastasis suppressor involved in inactivation of oncogenic forms of Ras proteins
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-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates
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-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, excreted enzyme enters the nucleus of HeLa and COS-1 cells and nicks chromosomal DNA in situ
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-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
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-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, extracellular enzyme contributes to ATP-induced cell death of macrophages
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-
?
ATP + NDP
ADP + NTP
Mycobacterium tuberculosis H37Ra / ATCC 25177
contributes to the maintenance of the cellular pools of all nucleoside triphosphates
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-
?
ATP + NDP
ADP + NTP
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates, extracellular enzyme contributes to ATP-induced cell death of macrophages
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-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, excreted enzyme enters the nucleus of HeLa and COS-1 cells and nicks chromosomal DNA in situ
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-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleoside triphosphates, involved in coleoptile elongation and anaerobic stress response
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-
?
ATP + NDP
ADP + NTP
contributes to the maintenance of the cellular pools of all nucleosides triphosphates, broad substrate specificity, in plants involved in different signaling pathways
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-
?
ATP + NDP
ADP + NTP
-
contributes to the maintenance of the cellular pools of all nucleosides triphosphates
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-
?
ATP + NDP
ADP + NTP
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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contributes to the maintenance of the cellular pools of all nucleosides triphosphates
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-
?
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
this reaction is a reversible phosphate transfer to both ribonucleoside and deoxyribonucleoside diphosphates using NTP as a phosphate donor to provide adequate nucleosides for RNA or DNA synthesis
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r
NDP + NTP
NTP + NDP
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may be involved in regulation of growth, development and signal-transduction processes
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-
?
NDP + NTP
NTP + NDP
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enzyme forms complexes with G protein beta gamma dimers and contributes to G protein activation
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r
NDP + NTP
NTP + NDP
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overview on roles in metabolic pathways and nucleic acid synthesis
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?
NDP + NTP
NTP + NDP
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major component of nucleoside triphosphate synthetic pathway
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-
?
NDP + NTP
NTP + NDP
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autophosphorylation and phosphorylation of histone H1
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-
?
NTP + NDP
NDP + NTP
NDPK is a key metabolic enzyme that catalyzes the synthesis of non-adenine nucleoside triphosphate by transferring the terminal phosphate between NDP and NTP
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r
additional information
?
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-
role of enzyme in dUTP detoxification to compensate for the absence of a dUTPase in Mimivirus
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?
additional information
?
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-
NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
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-
?
additional information
?
-
NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
-
-
?
additional information
?
-
-
NDPK2 is a H2O2 signaling protein that performs autophosphorylation. NDPK2 and H2O2 are involved in salt resistance, overview
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?
additional information
?
-
nucleoside diphosphate kinase is a housekeeping enzyme that maintains the intracellular levels of all (d)NTPs used in biosynthesis except ATP, but it also plays a significant role in signal transduction pathways involved in oxidative stress. The enzyme protects the plants against reactive ocygen species, heat, and salt stress, overview
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?
additional information
?
-
the enzyme's primary function is to maintain dNTP pools by converting deoxynucleotide diphosphates to triphosphates using ATP as the major phosphate donor
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-
?
additional information
?
-
-
the enzyme's primary function is to maintain dNTP pools by converting deoxynucleotide diphosphates to triphosphates using ATP as the major phosphate donor
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-
?
additional information
?
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critical role of the two amino acid residues, E134 and E135, at the carboxy-terminal region of NDK in determining the halophilic characteristics of the protein, overview
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?
additional information
?
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MDA-MB-435S cell-secreted NDPK-B supports tumour formation by modulating ATP levels locally to activate endothelial cell P2Y receptor-mediated angiogenesis, overview
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?
additional information
?
-
NDPKA is a housekeeping enzyme essential for the synthesis of nonadenine nucleoside and deoxynucleoside 5'-triphosphate
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?
additional information
?
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-
NDPKA is a housekeeping enzyme essential for the synthesis of nonadenine nucleoside and deoxynucleoside 5'-triphosphate
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?
additional information
?
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the enzyme catalyzes transfer of the gamma-phosphate from a nucleoside triphosphate, NTP, to a nucleoside diphosphate, NDP
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?
additional information
?
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the transfer of high energetic phosphate by NDPK and/or the beta subunit of G proteins can induce G protein activation. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers influencing the G protein activation and stability, mechanism, detailed overview
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?
additional information
?
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-
NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways
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?
additional information
?
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nucleoside diphosphate kinase B forms a functional complex with cell surface CFTR, binding analysis using peptide NDPK-B 36-54 (V36AMKFLRAS44EEHLKQHYID54), this region of NDPK-B, may constitute a key NDPK-B interaction domain for CFTR, the nucleotide binding domain 1 (NBD1, aa 351-727) of CFTR constitutes an NDPK-B interaction site with CFTR, surface plasmon resonance and NDPK-B and NBD1 protein-protein docking analysis
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?
additional information
?
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-
NdK is a stable enzyme capable of decreasing extracellular ATP levels
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?
additional information
?
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-
NdK is a stable enzyme capable of decreasing extracellular ATP levels
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?
additional information
?
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-
NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways
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?
additional information
?
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catalyzes cleavage of single strand DNA, oligonucleotide P1 used for experiments
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?
additional information
?
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-
catalyzes cleavage of single strand DNA, oligonucleotide P1 used for experiments
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?
additional information
?
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the enzyme binds to and inactivates the small GTPase Rac1 in the macrophage. This results in the exclusion of the Rac1 binding partner p67phox from phagosomes containing bacteria- or enzyme-coated latex beads. Exclusion of p67phox is associated with a defect of both NOX2 assembly and production of reactive oxygen species in response to wild-type bacteria
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?
additional information
?
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catalyzes cleavage of single strand DNA, oligonucleotide P1 used for experiments
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?
additional information
?
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NDK-1 plays an important role in protecting conidial viability under light stress in Neurospora crassa
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?
additional information
?
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-
NDK-1 plays an important role in protecting conidial viability under light stress in Neurospora crassa
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?
additional information
?
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-
NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways
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-
?
additional information
?
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-
key enzyme involved in the homeostasis of nucleoside triphosphates
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?
additional information
?
-
key enzyme involved in the homeostasis of nucleoside triphosphates
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?
additional information
?
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-
nucleoside diphosphate kinase is responsible for maintaining the nucleotide balance in the cell, but is also involved in regulatory functions that often are mediated via protein-protein interactions, differentially for adenylate kinase isozymes, overview
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?
additional information
?
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-
enzyme is involved in receptor-independent regulation of cAMP synthesis and contractility in intact cardiomyocytes and has histidine kinase activity for phosphorylation of G protein subunit beta phosphorylation at H266
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-
?
additional information
?
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-
In addition to the receptor-induced GDP/GTP exchange, G protein alpha subunits can be activated by a phosphate transfer via a plasma membrane-associated complex of NDPK B and G protein betagamma-dimers, Gbetagamma, requiring the intermediate phosphorylation of His266, the histidine kinase activity of NDPK B for Gbeta is important for the receptor-independent regulation of cAMP synthesis and contractility in intact cardiomyocytes, overview
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?
additional information
?
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-
the enzyme is involved in endoplasmic reticulum membranes structure formation, the mechanism of membrane extension involves direct lipid binding, as NDKB-bound phosphatidylinositol-4-phosphate, phosphatidylinositol-4,5-diphosphate, and phosphatidic acid. Binding to these anionic lipids requires clusters of basic residues on the surface of the NDKB hexamer. Amino acid changes in NDKB, that block lipid binding, also block endoplasmic reticulum network extension, overview
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?
additional information
?
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-
the transfer of high energetic phosphate by NDPK and/or the beta subunit of G proteins can induce G protein activation. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers influencing the G protein activation and stability, mechanism, detailed overview
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-
?
additional information
?
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kinetic parameters and regulation mechanisms of NDPK1 and NDPK2, overview
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-
?
