2.7.4.6: nucleoside-diphosphate kinase

This is an abbreviated version!
For detailed information about nucleoside-diphosphate kinase, go to the full flat file.

Reaction

Synonyms

AfNDK, Afu5g03490, ASNDK, At4g09320, At4g11010, At5g63310, HsNDK, kinase, nucleoside diphosphate (phosphorylating), mitochondrial nucleoside diphosphate kinase, MJ1265, More, NDK, NDK B, NDK-1, NDKB, NDP kinase, NDP kinase A, NDP kinase alpha, NDP kinase beta, NDPK, NDPK B, NDPK I, NDPK II, NDPK III, NDPK IIpn, NDPK In, NDPK-3, NDPK-B, NDPK-C, NDPK-D, NDPK-In, NDPK1, NDPK2, NDPK3, NDPK3a, NDPKA, NDPKB, NM23, NM23 metastasis suppressor, Nm23-H1, NM23-H2, NM23-H4, NME1, NME2, NME3, NME4, nucleoside 5'-diphosphate kinase, nucleoside diphosphate (UDP) kinase, nucleoside diphosphate kinase, nucleoside diphosphate kinase 1, nucleoside diphosphate kinase 2, nucleoside diphosphate kinase 3, nucleoside diphosphate kinase 3a, nucleoside diphosphate kinase A, nucleoside diphosphate kinase B, nucleoside diphosphate kinase C, nucleoside diphosphate kinase D, nucleoside diphosphate kinase-1, nucleoside diphosphate kinase-2, nucleoside diphosphate kinases alpha, nucleoside diphosphate kinases beta, nucleoside diphosphate phosphotransferase, nucleoside diphosphokinase, nucleoside-diphosphate kinase 3, nucleotide diphosphate kinase, nucleotide phosphate kinase, ORF454, Os12g36194, OsNDPK2, SwoH, TcNDPK1, TcNDPK3, UDP kinase, uridine diphosphate kinase, WSL12, YSS2 protein

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.4 Phosphotransferases with a phosphate group as acceptor

                2.7.4.6 nucleoside-diphosphate kinase

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Results	in table
6	Activating Compound
51439	AA Sequence
6	Application
1	CAS Registry Number
97	Cloned(Commentary)
24	Cofactor
42	Crystallization (Commentary)
5761	Disease/ Diagnostics
7	Expression
56	General Information
12	General Stability
7	IC50 Value
46	Inhibitors
26	kcat/KM [mM/s]
1	Ki Value [mM]
136	KM Value [mM]
121	Localization
167	Metals/Ions
148	Molecular Weight [Da]
124	Natural Substrates/ Products (Substrates)
966	Organism
28	Pathway
770	PDB ID
61	pH Optimum
4	pH Range
7	pH Stability
19	pI Value
17	Posttranslational Modification
139	Protein Variants
92	Purification (Commentary)
26	Reaction
1	Reaction Type
283	Reference
8	Renatured (Commentary)
238	Source Tissue
79	Specific Activity [micromol/min/mg]
8	Storage Stability
725	Substrates and Products (Substrate)
186	Subunits
322	Synonyms
1	Systematic Name
39	Temperature Optimum [°C]
4	Temperature Range [°C]
46	Temperature Stability [°C]
29	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 2.7.4.6 - nucleoside-diphosphate kinase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

67.6 - 415

ADP

9 entries

34 - 626

ATP

2 entries

9.1 - 40.2

CTP

4 entries

4

dTDP

white spot syndrome virus

-

pH 7.5, temperature not specified in the publication

738558

29.2 - 468

GTP

4 entries

135

ITP

Aspergillus fumigatus

Q7Z8P9

pH 8.0, 30°C

761072

10.4 - 79.8

TTP

4 entries

104

UTP

Aspergillus fumigatus

Q7Z8P9

pH 8.0, 30°C

761072

67.6

ADP

Oryza sativa

-

isozyme NDPK2, with CTP as cosubstrate, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

69.9

ADP

Oryza sativa

-

isozyme NDPK1, with GTP as cosubstrate, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

140

ADP

Oryza sativa

-

isozyme NDPK1, with TTP as cosubstrate, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

143

ADP

Oryza sativa

-

isozyme NDPK3, with GTP as cosubstrate, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

154

ADP

Oryza sativa

-

isozyme NDPK3, with CTP as cosubstrate, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

180

ADP

Oryza sativa

-

isozyme NDPK2, with TTP as cosubstrate, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

210

ADP

Oryza sativa

-

isozyme NDPK2, with GTP as cosubstrate, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

310

ADP

Oryza sativa

-

isozyme NDPK3, with TTP as cosubstrate, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

415

ADP

Oryza sativa

-

isozyme NDPK1, with CTP as cosubstrate, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

34

ATP

white spot syndrome virus

-

pH 7.5, temperature not specified in the publication

738558

626

ATP

Aspergillus fumigatus

Q7Z8P9

pH 8.0, 30°C

761072

9.1

CTP

Oryza sativa

-

isozyme NDPK2, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

16.9

CTP

Oryza sativa

-

isozyme NDPK3, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

34.1

CTP

Oryza sativa

-

isozyme NDPK1, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

40.2

CTP

Aspergillus fumigatus

Q7Z8P9

pH 8.0, 30°C

761072

29.2

GTP

Oryza sativa

-

isozyme NDPK1, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

35.1

GTP

Oryza sativa

-

isozyme NDPK3, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

61.6

GTP

Oryza sativa

-

isozyme NDPK2, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

468

GTP

Aspergillus fumigatus

Q7Z8P9

pH 8.0, 30°C

761072

10.4

TTP

Oryza sativa

-

isozyme NDPK1, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

16

TTP

Oryza sativa

-

isozyme NDPK2, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

25

TTP

Oryza sativa

-

isozyme NDPK3, in 4 mM Tris-HCl, pH 7.5, 100 mM KCl, 25 mM MgCl2, at 25°C

721870

79.8

TTP

Aspergillus fumigatus

Q7Z8P9

pH 8.0, 30°C

761072