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drug target
as an essential enzyme in Aspergillus fumigatus, nucleoside-diphosphate kinase is an attractive target for antifungals
drug target
the enzyme may have potential target as a new therapeutic strategy against white spot syndrome virus infection in shrimp
drug target
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as an essential enzyme in Aspergillus fumigatus, nucleoside-diphosphate kinase is an attractive target for antifungals
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evolution
enzymes from Halomonas sp strain 593 and Chromohalobacter salexigens strain DSM3043 show very high sequence homology to each other, in both enzymes, residue C139 is conserved
evolution
enzymes from Halomonas sp strain 593 and Chromohalobacter salexigens strain DSM3043 show very high sequence homology to each other, in both enzymes, residue C139 is conserved
evolution
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enzymes from Halomonas sp strain 593 and Chromohalobacter salexigens strain DSM3043 show very high sequence homology to each other, in both enzymes, residue C139 is conserved
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malfunction
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loss of Nm23-H1 in diploid cells leads to cytokinetic furrow regression, followed by cytokinesis failure and generationof tetraploid cells. The loss of Nm23-H1, an event suspected to promote metastasis, additionally functions at an earlier stage of tumor development to drive the acquisition of chromosomal instability
malfunction
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the stable knockout mutant Mtb Ndk-AS displays attenuated intracellular survival along with reduced persistence in the lungs of infected mice. Mutant Mtb Ndk-AS, which lost the capacity to disrupt Rac1-p67phox interaction, induces a strong ROS production. Given the established link between NOX2 activation and apoptosis, the proportion of Annexin V positive cells and levels of intracellular active caspase 3 are significantly higher in cells infected with Mtb Ndk-AS compared to wild-type Mtb. Knockdown of Ndk converts Mtb into a pro-apoptotic mutant strain that has a phenotype of increased susceptibility to intracellular killing and reduced virulence in vivo, phenotype, overview. Disruption of Ndk expression converts Mtb into a mutant strain that induces strong ROS and apoptosis responses. This phenotype is associated with reduced survival of Ndk mutant in vitro and in vivo
malfunction
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deletion in the ndk gene results in significantly reduced adhesion and invasion of Epithelioma papulosum cyprini (EPC) cells and biofilm formation
malfunction
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depletion of NME3 causes renal developmental defects
malfunction
depletion of NME3 causes renal developmental defects
malfunction
mutations in the NME3 gene may aggravate the ciliopathy phenotypes observed in humans
malfunction
nucleoside diphosphate kinase B depletion alone impairs caveolae formation, vascular endothelial growth factor (VEGF)-induced phosphorylation of c-Src/Cav-1 but not of ERK1/2/AKT/eNOS. Primary mouse brain endothelial cells from nucleoside diphosphate kinase Bx02-/-x02 mice show no change in caveolae content and transendothelial-electrical resistance upon VEGF stimulation. Nucleoside diphosphate kinase Bx02-/-x02 primary mouse brain endothelial cells display an accumulation of intracellular vesicles and increased caveolin-1 levels. Dextran tracer analysis shows increased vascular permeability in the brain of nucleoside diphosphate kinase Bx02-/-x02 mice compared to wild type
malfunction
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deletion in the ndk gene results in significantly reduced adhesion and invasion of Epithelioma papulosum cyprini (EPC) cells and biofilm formation
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metabolism
nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-kappaB signaling pathways
metabolism
proteomic analysis in wild-type and knockout mutant plants under normal or phenanthrene stress conditions, genes expression analysis, overview
metabolism
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proteomic analysis in wild-type and knockout mutant plants under normal or phenanthrene stress conditions, genes expression analysis, overview
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physiological function
NDPK-D is proposed to couple ATP export through adenine nucleotide translocator to the synthesis of the other nucleoside triphosphates e.g. GTP
physiological function
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isoform NDPK-D alters membrane organisation in terms of fluidity, hydration and lipid clusterin, mediates contact sites and contributes to the mitochondrial intermembrane space structuring
physiological function
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nucleoside diphosphate kinase exhibits GTPase activating protein activity towards Rab5 and Rab7. The enzyme is a putative virulence factor that inhibits phagosome maturation and promotes survival of mycobacteria within the macrophage
physiological function
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nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis
physiological function
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the enzyme inhibits phagocytosis (but not amoeboid motility) and macropinocytosis which contrasts with its positive regulatory role in micropinocytosis. The enzyme has no effect on multicellular development and promotes growth in liquid
physiological function
there is a strong interaction between isoform NDPK2 and CAT1 in R3-1 plants, which possibly plays a vital role in the antioxidant defense against reactive oxygen species
physiological function
key enzyme in maintaining cellular pools of all nucleoside triphosphates
physiological function
Arabidopsis thaliana nucleoside diphosphate kinase, NDPK-3, is involved in stress signaling in response to polycyclic aromatic hydrocarbon exposure. Isozyme NDPK3 is a positive regulator in the Arabidopsis response to phenanthrene stress
physiological function
nucleoside diphosphate kinase is a key enzyme in the control of cellular concentrations of nucleoside triphosphates, and plays important roles in many cellular processes
physiological function
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nucleoside diphosphate kinase is involved in the catalysis of the transfer of gamma-phosphate from nucleoside triphosphate to nucleoside diphosphate and thus maintains the nucleotide pool. The dNTPs that are formed are used as precursors for DNA and RNA synthesis. NTPs, specifically GTP, are important for cellular macromolecular synthesis and signalling mechanisms. Ndk plays a pivotal role in crucial events like bacterial growth, signal transduction, and pathogenicity
physiological function
nucleoside diphosphate kinase mediates bacterially induced toxicity against eukaryotic cells. Bacterial Ndk, with the aid of an additional bacterial factor, flagellin, induces expression of the proinflammatory cytokines interleukin-1alpha and -1beta in human host cells A-549. Cytokine induction appears to be dependent on the kinase activity of Ndk and is mediated via the NF-kappaB signaling pathway. Flagellin is required for the induction of the IL-1alpha and IL-1beta genes. Ndk activates the Akt signaling pathway, which acts upstream of NF-kappaB, as well as caspase-1, which is a key component of inflammasome
physiological function
role of interaction and nucleoside diphosphate kinase B in regulation of the cystic fibrosis transmembrane conductance regulator function by cAMP-dependent protein kinase A, overview. Nucleoside diphosphate kinase B selectively forms a functional complex with CFTR, the nucleotide binding domain 1 (NBD1, aa 351-727) of CFTR constitutes an NDPK-B interaction site with CFTR, but NDPK-B associates only with cell surface CFTR. A functional interaction between CFTR, AMPKalpha1 and NDPK-A exists which is independent of NDPK-B. NDPK-B is important for the cAMP/PKA regulation of CFTR function
physiological function
the enzyme catalyzes the third phosphorylation of nucleoside diphosphates, leading to nucleoside triphosphates for DNA replication. Enzyme NDK may phosphorylate nucleotide analogues to inhibit the viral infections that attack this organism
physiological function
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the enzyme is involved in the mechanism of Mycobacterium tuberculosis persistence in the host macrophage and inactivates small GTPases leading to evasion of innate immunity. Nucleoside diphosphate kinase contributes to phagosome maturation arrest via inactivation of Rab5 and Rab7. Ndk also targets and inactivates the small GTPase Rac1, an essential component of the macrophage NADPH oxidase (NOX2) complex. Ndk-dependent inactivation of Rac1 is associated with reduced NOX2-mediated production of reactive oxygen species (ROS) and ROS-dependent apoptosis. Ndk-mediated inhibition of ROS reduces the macrophage killing capability. The organism uses Ndk as GAP activity towards macrophage Rac1
physiological function
key enzyme regulating NDP/NTP homeostasis
physiological function
NME1 depletion impacts migration and differentiation but not proliferation in neuroblastoma cells. Candidate targets of NME1 histidine kinase activity include ENO1, GAPDH, and PKM
physiological function
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nucleoside diphosphate kinase NDK-1 functions as an effector protein in interaction between Mayetiola destructor and wheat
physiological function
parasites overexpressing TcNDPK1 are able to withstand genotoxic stresses caused by hydrogen peroxide, phleomycin and hidroxyurea. They also present less genomic damage and augmented levels of poly(ADP) ribose and poly(ADP)ribose polymerase, an enzyme involved in DNA repair
physiological function
the enzyme has an important role influencing the replication of white spot syndrome virus (WSSV) replication in shrimp. Increased nucleoside diphosphate kinase activity induces white spot syndrome virus infection in Litopenaeus vannamei
physiological function
the enzyme has important roles in chloroplast biogenesis
physiological function
the enzyme is essential for its viability
physiological function
the enzyme is required for nucleoside triphosphate homeostasis. It is also required for the correct localization of caveolin-1 at the plasma membrane and the formation of caveolae
physiological function
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the enzyme NME3 is required for determining left-right body axis specification and ciliogenesis
physiological function
the enzyme NME3 is required for determining left-right body axis specification and ciliogenesis
physiological function
the enzyme plays a key role in the transfer of energy between the cytosolic adenine and uridine nucleotide pools and in the distribution of carbon between starch and cellulose
physiological function
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the enzyme reveals a key role in adhesion and virulence
physiological function
the mitochondrial NME4 protein has multiple functions in bioenergetics and phospholipid signaling. It acts as a cardiolipin-dependent mitochondrial switch between a phosphotransfer function serving local GTP supply and a cardiolipin transfer function for signaling apoptosis, mitophagy and putative other cellular processes. It can fuel GTP to the dynamin-like GTPase OPA1 and thus regulate mitochondrial dynamics. Independently of its kinase activity, NDPK-D/NME4 can promote the intermembrane cardiolipin transfer to the mitochondrial surface. Under these conditions, it promotes apoptosis to eliminate damaged cells or mitophagy to eliminate damaged mitochondria, both important quality control mechanisms. NDPK-D is a key player in the control of cell homeostasis and an important contributor to the quality control of mitochondria
physiological function
the mitochondrial NME4 protein has multiple functions in bioenergetics and phospholipid signaling. It acts as a cardiolipin-dependent mitochondrial switch between a phosphotransfer function serving local GTP supply and a cardiolipin transfer function for signaling apoptosis, mitophagy and putative other cellular processes. It can fuel GTP to the dynamin-like GTPase OPA1 and thus regulate mitochondrial dynamics. Independently of its kinase activity, NDPK-D/NME4 can promote the intermembrane cardiolipin transfer to the mitochondrial surface. Under these conditions, it promotes apoptosis to eliminate damaged cells or mitophagy to eliminate damaged mitochondria, both important quality control mechanisms. NDPK-D is a key player in the control of cell homeostasis and an important contributor to the quality control of mitochondria
physiological function
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the physical interaction between phytochrome A in the Pfr form and NDPKx02In results in a significant increase in the kinase activity of the enzyme (NDPK-In). NDPK-In may function as a protein kinase regulated by light
physiological function
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WSL12 plays an important role in chloroplast development and chlorophyll biosynthesis by regulating the expression levels of related genes. In addition, WSL12 also affects the response to abiotic stress, such as abscisic acid and salinity in rice, and is beneficial to molecular breeding of stress tolerance
physiological function
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the enzyme inhibits phagocytosis (but not amoeboid motility) and macropinocytosis which contrasts with its positive regulatory role in micropinocytosis. The enzyme has no effect on multicellular development and promotes growth in liquid
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physiological function
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key enzyme in maintaining cellular pools of all nucleoside triphosphates
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physiological function
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parasites overexpressing TcNDPK1 are able to withstand genotoxic stresses caused by hydrogen peroxide, phleomycin and hidroxyurea. They also present less genomic damage and augmented levels of poly(ADP) ribose and poly(ADP)ribose polymerase, an enzyme involved in DNA repair
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physiological function
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nucleoside diphosphate kinase is a key enzyme in the control of cellular concentrations of nucleoside triphosphates, and plays important roles in many cellular processes
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physiological function
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Arabidopsis thaliana nucleoside diphosphate kinase, NDPK-3, is involved in stress signaling in response to polycyclic aromatic hydrocarbon exposure. Isozyme NDPK3 is a positive regulator in the Arabidopsis response to phenanthrene stress
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physiological function
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the enzyme reveals a key role in adhesion and virulence
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physiological function
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the enzyme is essential for its viability
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additional information
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Acinetobacter baumannii NDK structure comparison with the structure of the Myxococcus xanthus enzyme NDK. Acinetobacter baumannii NDK might share a similar catalytic mechanism with Myxococcus xanthus NDK
additional information
LvNDK has a nucleotide-binding site and a catalytic histidine nucleophile His117, which is part of a phosphorelay that transfers a phosphoryl group obtained from ATP to the nucleoside diphosphate, substrate binding structures, overview
additional information
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LvNDK has a nucleotide-binding site and a catalytic histidine nucleophile His117, which is part of a phosphorelay that transfers a phosphoryl group obtained from ATP to the nucleoside diphosphate, substrate binding structures, overview