2.7.4.21: inositol-hexakisphosphate 5-kinase
This is an abbreviated version!
For detailed information about inositol-hexakisphosphate 5-kinase, go to the full flat file.
Word Map on EC 2.7.4.21
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2.7.4.21
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pyrophosphate
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polyphosphate
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pp-insps
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tetrakisphosphate
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ppip5ks
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bis-diphosphoinositol
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pyrophosphorylation
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5-insp7
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5-diphosphoinositol
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medicine
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ptdins3,4,5p3
- 2.7.4.21
- pyrophosphate
- polyphosphate
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pp-insps
- tetrakisphosphate
- ppip5ks
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bis-diphosphoinositol
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pyrophosphorylation
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5-insp7
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5-diphosphoinositol
- medicine
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ptdins3,4,5p3
Reaction
Synonyms
AtIPK2alpha, AtIpk2beta, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase, AtVip1, AtVip2, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol pentakisphosphate synthetase, EC 2.7.1.152, EhIP6KA, IHPK2, inositol hexakisphosphate 5-kinase, inositol hexakisphosphate kinase, inositol hexakisphosphate kinase 1, inositol hexakisphosphate kinase 2, inositol hexakisphosphate kinase 3, inositol hexakisphosphate kinase type 2, inositol hexakisphosphate kinase-1, inositol hexakisphosphate kinase-2, inositol hexakisphosphate kinase-3, inositol polyphosphate kinase, inositol-hexakisphosphate kinase, InsP6 kinase, InsP6-kinase, InsP6K1, InsP6K2, InsP6K3, IP6 kinase, IP6 kinase 1, IP6K, IP6K1, IP6K2, IP6K3, Ipk2, IPMK, Kcs1, kinase (phosphorylating), inositol hexakisphosphate, More, Pi uptake stimulator, PiUS, PPIP5K1, PPIP5K2, RID-2
ECTree
2.7.4.21 inositol-hexakisphosphate 5-kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
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-
-
r
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,3-bis(diphosphate) 2,4,5,6-tetrakisphosphate
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
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-
-
?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1-triphosphate 2,3,4,5,6-pentakisphosphate
ATP + 1D-myo-inositol 1-diphosphate pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate
-
-
-
r
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
ATP + 1D-myo-inositol hexakisphosphate
ADP + diphosphoinositol pentakisphosphate + bisdiphosphoinositol tetrakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate
ADP + diphospho-1D-myo-inositol tetrakisphosphate
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-
-
?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,3-bis(diphosphate) 2,4,5,6-tetrakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,3-bis(diphosphate) 2,4,5,6-tetrakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1-triphosphate 2,3,4,5,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1-triphosphate 2,3,4,5,6-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol 1-diphosphate pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
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-
-
?
ATP + 1D-myo-inositol 1-diphosphate pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
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-
-
?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
-
-
r
ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
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-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
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-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
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-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
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-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
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-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
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-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
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-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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apoptosis regulation
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-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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forward and reverse reaction are random bireactant systems
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?, r
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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enzyme is responsible for the biosynthesis of diphospho-myo-inositol pentakisphosphate. The enzyme also has a ATP synthase activity, implying that 5-diphospho-1D-myo-inositol pentakisphosphate functions as high-energy phosphate donor
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r
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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-
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?
additional information
?
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the consensus PxxxDxKxG motif is responsible for substrate binding and is highly conserved in all known IPK2s
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?
additional information
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the consensus PxxxDxKxG motif is responsible for substrate binding and is highly conserved in all known IPK2s
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?
additional information
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secondary to its InsP6 kinase activity, also phosphorylates the 6-OH of Ins(1,4,5)P3, an inositol phosphate multikinase (IPMK)-like activity. IPMK itself is positionally promiscuous in that it is a 3-, 5- and 6-kinase. The enzyme also shows significant InsP3 kinase activity
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?
additional information
?
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secondary to its InsP6 kinase activity, also phosphorylates the 6-OH of Ins(1,4,5)P3, an inositol phosphate multikinase (IPMK)-like activity. IPMK itself is positionally promiscuous in that it is a 3-, 5- and 6-kinase. The enzyme also shows significant InsP3 kinase activity
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?
additional information
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EhIP6KA, like mammalian IP6Ks, converts InsP6 to 5-InsP7. The 5-phosphate group on InsP6 is diphosphorylated by EhIP6KA. The enzyme phosphorylates Ins(1,3,4,5,6)P5, and the major product co-elutes with a PP-[3H]InsP4 standard, no InsP6 is formed. The first order rate constant for Ins(1,3,4,5,6)P5 phosphorylation is 40fold lower than that for InsP6. The rate of phosphorylation of Ins(1,4,5)P3, is 220fold slower than that for InsP6, either the 2- or the 6-OH of Ins(1,4,5)P3 are phosphorylated. Ins(1,4,5,6)P4 is the major InsP4 product formed from Ins(1,4,5)P, with phosphorylation of an inositol phosphate at the 2-position. Steric restrictions prevent InsP6 from occupying the same space as Ins(1,4,5)P3 in the substrate-binding pocket. Substrate binding and specificities, overview
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?
additional information
?
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EhIP6KA, like mammalian IP6Ks, converts InsP6 to 5-InsP7. The 5-phosphate group on InsP6 is diphosphorylated by EhIP6KA. The enzyme phosphorylates Ins(1,3,4,5,6)P5, and the major product co-elutes with a PP-[3H]InsP4 standard, no InsP6 is formed. The first order rate constant for Ins(1,3,4,5,6)P5 phosphorylation is 40fold lower than that for InsP6. The rate of phosphorylation of Ins(1,4,5)P3, is 220fold slower than that for InsP6, either the 2- or the 6-OH of Ins(1,4,5)P3 are phosphorylated. Ins(1,4,5,6)P4 is the major InsP4 product formed from Ins(1,4,5)P, with phosphorylation of an inositol phosphate at the 2-position. Steric restrictions prevent InsP6 from occupying the same space as Ins(1,4,5)P3 in the substrate-binding pocket. Substrate binding and specificities, overview
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?
additional information
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role of the enzyme as a mediator of growth inhibition and apoptosis in response to interferon-beta treatment. The cellular level of the enzyme is posttranscriptionally enhanced by interferon-beta, in ovarian carcinoma cells
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?
additional information
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role of the enzyme as a mediator of growth inhibition and apoptosis in response to interferon-beta treatment. The cellular level of the enzyme is posttranscriptionally enhanced by interferon-beta, in ovarian carcinoma cells
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?
additional information
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IP6Ks change their kinase activity towards InsP6 at a decreasing ATP/ADP ratio to an ADP phosphotransferase activity and dephosphorylate InsP6. Enantioselective analysis reveals that Ins(2,3,4,5,6)P5 is the main InsP5 product of the IP6K reaction
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?
additional information
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the bifunctional enzyme also catalyzes the reaction of EC 2.7.4.24. The enzyme exhibits an unusual, nonproductive, substrate-stimulated ATPase activity, that is stimulated by the natural substratesand by 5-O-alpha-phosphonoacetyl-myo-inositol 1,2,3,4,6-pentakisphosphate and 2-O-benzyl-5-O-alpha-phosphonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate. The enzyme has two adjacent ligand-binding sites
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?
additional information
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enzyme additionally catalyzes the reaction of EC 2.7.4.24, i.e. conversion of 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate to 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate. The kinase activities toward 1D-myo-inositol hexakisphosphate are 4fold lower than the kinase activites toward 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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additional information
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enzyme additionally catalyzes the reaction of EC 2.7.4.24, i.e. conversion of 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate to 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate. The kinase activities toward 1D-myo-inositol hexakisphosphate are 4fold lower than the kinase activites toward 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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additional information
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IHPK2 binds to tumor necrosis factor receptor-associated factor 2 and interferes with phosphorylation of transforming growth factor beta-activated kinase 1, TAK1, thereby inhibiting NF-kappaB signaling. IHPK2 contains two sites required for TRAF2 binding, Ser347 and Ser359. IHPK2-TRAF2 binding leads to attenuation of TAK1- and NF-kappa B-mediated signaling and is partially responsible for the apoptotic activity of IHPK2. A portion of the death-promoting function of IHPK2 is independent of its kinase activity
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?
additional information
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IP6K2 belongs to a family of enzymes generating the inositol pyrophosphate IP7 [diphosphoinositol pentakisphosphate (5-PP-IP5)], it mediates apoptosis, increased IP6K2 activity sensitizes cancer cells to stressors, whereas its depletion blocks cell death
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additional information
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enzyme IP6K3 physiologically binds to the cytoskeletal proteins adducin and spectrin in mouse cerebellum
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additional information
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the enzyme generates inositol 1,3,4,5-tetrakisphosphate (InsP4) and InsP5
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additional information
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the enzyme generates inositol 1,3,4,5-tetrakisphosphate (InsP4) and InsP5
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?
additional information
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the enzyme generates inositol 1,3,4,5-tetrakisphosphate (InsP4) and InsP5
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?
additional information
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isoforms IP6K1 and IP6K2 bind to AP3B1protein
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additional information
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IP6Ks change their kinase activity towards InsP6 at a decreasing ATP/ADP ratio to an ADP phosphotransferase activity and dephosphorylate InsP6. Enantioselective analysis reveals that Ins(2,3,4,5,6)P5 is the main InsP5 product of the IP6K reaction
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