2.7.4.21: inositol-hexakisphosphate 5-kinase This is an abbreviated version! For detailed information about inositol-hexakisphosphate 5-kinase, go to the full flat file .
Reaction
ATP +
1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate =
ADP +
1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Synonyms AtIPK2alpha, AtIpk2beta, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase, AtVip1, AtVip2, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol pentakisphosphate synthetase, EC 2.7.1.152, EhIP6KA, IHPK2, inositol hexakisphosphate 5-kinase, inositol hexakisphosphate kinase, inositol hexakisphosphate kinase 1, inositol hexakisphosphate kinase 2, inositol hexakisphosphate kinase 3, inositol hexakisphosphate kinase type 2, inositol hexakisphosphate kinase-1, inositol hexakisphosphate kinase-2, inositol hexakisphosphate kinase-3, inositol polyphosphate kinase, inositol-hexakisphosphate kinase, InsP6 kinase, InsP6-kinase, InsP6K1, InsP6K2, InsP6K3, IP6 kinase, IP6 kinase 1, IP6K, IP6K1, IP6K2, IP6K3, Ipk2, IPMK, Kcs1, kinase (phosphorylating), inositol hexakisphosphate, More, Pi uptake stimulator, PiUS, PPIP5K1, PPIP5K2, RID-2
ECTree
Source Tissue
Source Tissue on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase
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male, isozymes AtIPK2alpha and AtIPK2beta have overlapping expression in male gametophyte
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cell culture
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isozyme IP6K3 is highly concentrated in the brain in cerebellar Purkinje cells
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faintly expressed
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spinal cord
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of the mammalian spinal cord
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high expression
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coexpression with Hsp90
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immunohistochemic analysis of the enzyme in wild-type and mutant mouse brains, overview
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highest activity occurs in Purkinje cells with somewhat lower levels in granule cells. In hippocampus substantial densities occur in CA1-CA4 layers of the hippocampus as well as the dentate gyrus
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faintly expressed
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weak activity
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low activity
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moderate activity
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faintly expressed
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coexpression with Hsp90
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weak
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low activity
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weak activity
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faintly expressed
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MC-3T3 osteoblasts express IP6K1 and IP6K2 mRNA more than 25fold more abundantly than IP6K3
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MC3T3 osteoblasts express IP6K1 and IP6K2 mRNA more than 25fold more abundantly than IP6K3
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inositol hexakisphosphate kinase 3 is highly expressed at the leading edge of migrating cells
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inositol hexakisphosphate kinase 3 is highly expressed at the leading edge of migrating cells
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high activity
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high activity
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high activity
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high activity
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co-localization with phosphorylated TDP-43 of InsP6K2 in the cytoplasm of anterior horn cells of the spinal cord
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anterior horn cell
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low activity
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additional information
in vitro and in vivo analysis of pollen germination and pollen tube growth of wild-type and mutant strains, detection of pollen tube guidance in cross-pollination, overview
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additional information
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