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2.7.4.21: inositol-hexakisphosphate 5-kinase

This is an abbreviated version!
For detailed information about inositol-hexakisphosphate 5-kinase, go to the full flat file.

Word Map on EC 2.7.4.21

Reaction

ATP
+
1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
=
ADP
+
1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Synonyms

AtIPK2alpha, AtIpk2beta, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase, AtVip1, AtVip2, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol pentakisphosphate synthetase, EC 2.7.1.152, EhIP6KA, IHPK2, inositol hexakisphosphate 5-kinase, inositol hexakisphosphate kinase, inositol hexakisphosphate kinase 1, inositol hexakisphosphate kinase 2, inositol hexakisphosphate kinase 3, inositol hexakisphosphate kinase type 2, inositol hexakisphosphate kinase-1, inositol hexakisphosphate kinase-2, inositol hexakisphosphate kinase-3, inositol polyphosphate kinase, inositol-hexakisphosphate kinase, InsP6 kinase, InsP6-kinase, InsP6K1, InsP6K2, InsP6K3, IP6 kinase, IP6 kinase 1, IP6K, IP6K1, IP6K2, IP6K3, Ipk2, IPMK, Kcs1, kinase (phosphorylating), inositol hexakisphosphate, More, Pi uptake stimulator, PiUS, PPIP5K1, PPIP5K2, RID-2

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.21 inositol-hexakisphosphate 5-kinase

Reference

Reference on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Saiardi, A.; Erdjument-Bromage, H.; Snowman, A.M.; Tempst, P.; Snyder, S.H.
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases
Curr. Biol.
9
1323-1326
1999
Mus musculus (Q6PD10), Homo sapiens (Q9UHH9)
Manually annotated by BRENDA team
Voglmaier, S.M.; Bembenek, M.E.; Kaplin, A.I.; Dorman, G.; Olszewski, J.D.; Prestwich, G.D.; Snyder, S.H.
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor
Proc. Natl. Acad. Sci. USA
93
4305-4310
1996
Rattus norvegicus
Manually annotated by BRENDA team
Albert, C.; Safrany, S.T.; Bembenek, M.E.; Reddy, K.M.; Reddy, K.K.; Falck, J.R.; Bröcker, M.; Shears, S.B.; Mayr, G.W.
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells
Biochem. J.
327
553-560
1997
Cricetulus griseus, Homo sapiens, Mus musculus
-
Manually annotated by BRENDA team
Morrison, B.H.; Bauer, J.A.; Kalvakolanu, D.V.; Lindner, D.J.
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells
J. Biol. Chem.
276
24965-24970
2001
Homo sapiens (Q9UHH9), Homo sapiens
Manually annotated by BRENDA team
Saiardi, A.; Nagata, E.; Luo, H.R.; Snowman, A.M.; Snyder, S.H.
Identification and characterization of a novel inositol hexakisphosphate kinase
J. Biol. Chem.
276
39179-39185
2001
Homo sapiens (Q96PC2), Mus musculus
Manually annotated by BRENDA team
Morrison, B.H.; Tang, Z.; Jacobs, B.S.; Bauer, J.A.; Lindner, D.J.
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma
Biochem. J.
385
595-603
2005
Homo sapiens
Manually annotated by BRENDA team
Schell, M.J.; Letcher, A.J.; Brearley, C.A.; Biber, J.; Murer, H.; Irvine, R.F.
PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase
FEBS Lett.
461
169-172
1999
Xenopus sp.
Manually annotated by BRENDA team
Nagata, E.; Luo, H.R.; Saiardi, A.; Bae, B.I.; Suzuki, N.; Snyder, S.H.
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death
J. Biol. Chem.
280
1634-1640
2005
Homo sapiens
Manually annotated by BRENDA team
Morrison, B.H.; Bauer, J.A.; Hu, J.; Grane, R.W.; Ozdemir, A.M.; Chawla-Sarkar, M.; Gong, B.; Almasan, A.; Kalvakolanu, D.V.; Lindner, D.J.
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics
Oncogene
21
1882-1889
2002
Homo sapiens
Manually annotated by BRENDA team
Morrison, B.H.; Bauer, J.A.; Lupica, J.A.; Tang, Z.; Schmidt, H.; DiDonato, J.A.; Lindner, D.J.
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation
J. Biol. Chem.
282
15349-15356
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Chakraborty, A.; Koldobskiy, M.A.; Sixt, K.M.; Juluri, K.M.; Mustafa, A.K.; Snowman, A.M.; van Rossum, D.B.; Patterson, R.L.; Snyder, S.H.
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2
Proc. Natl. Acad. Sci. USA
105
1134-1139
2008
Mus musculus
Manually annotated by BRENDA team
Bhandari, R.; Juluri, K.R.; Resnick, A.C.; Snyder, S.H.
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis
Proc. Natl. Acad. Sci. USA
105
2349-2353
2008
Mus musculus
Manually annotated by BRENDA team
Azevedo, C.; Szijgyarto, Z.; Saiardi, A.
The signaling role of inositol hexakisphosphate kinases (IP6Ks)
Adv. Enzyme Regul.
51
74-82
2011
Rattus norvegicus
Manually annotated by BRENDA team
Weaver, J.D.; Wang, H.; Shears, S.B.
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment
Biosci. Rep.
33
e00022
2013
Homo sapiens (O43314), Homo sapiens
Manually annotated by BRENDA team
Nagata, E.; Saiardi, A.; Tsukamoto, H.; Okada, Y.; Itoh, Y.; Satoh, T.; Itoh, J.; Margolis, R.L.; Takizawa, S.; Sawa, A.; Takagi, S.
Inositol hexakisphosphate kinases induce cell death in Huntington disease
J. Biol. Chem.
286
26680-26686
2011
Homo sapiens
Manually annotated by BRENDA team
Jadav, R.S.; Chanduri, M.V.; Sengupta, S.; Bhandari, R.
Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair
J. Biol. Chem.
288
3312-3321
2013
Mus musculus
Manually annotated by BRENDA team
Chakraborty, A.; Latapy, C.; Xu, J.; Snyder, S.H.; Beaulieu, J.M.
Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways
Mol. Psychiatry
19
284-293
2014
Mus musculus
Manually annotated by BRENDA team
Prasad, A.; Jia, Y.; Chakraborty, A.; Li, Y.; Jain, S.K.; Zhong, J.; Roy, S.G.; Loison, F.; Mondal, S.; Sakai, J.; Blanchard, C.; Snyder, S.H.; Luo, H.R.
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling
Nat. Immunol.
12
752-760
2011
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Sarmah, B.; Wente, S.R.
Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway
Proc. Natl. Acad. Sci. USA
107
19921-19926
2010
Danio rerio
Manually annotated by BRENDA team
Koldobskiy, M.A.; Chakraborty, A.; Werner, J.K.; Snowman, A.M.; Juluri, K.R.; Vandiver, M.S.; Kim, S.; Heletz, S.; Snyder, S.H.
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
Proc. Natl. Acad. Sci. USA
107
20947-20951
2010
Homo sapiens
Manually annotated by BRENDA team
Zhang, Z.; Liang, D.; Gao, X.; Zhao, C.; Qin, X.; Xu, Y.; Su, T.; Sun, D.; Li, W.; Wang, H.; Liu, B.; Cao, F.
Selective inhibition of inositol hexakisphosphate kinases (IP6Ks) enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction
Basic Res. Cardiol.
109
417
2014
Mus musculus (Q6PD10), Mus musculus (Q6ZQB6), Mus musculus (Q80V72), Mus musculus C57BL/6a (Q6PD10), Mus musculus C57BL/6a (Q6ZQB6), Mus musculus C57BL/6a (Q80V72)
Manually annotated by BRENDA team
Wundenberg, T.; Grabinski, N.; Lin, H.; Mayr, G.W.
Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio
Biochem. J.
462
173-184
2014
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Chanduri, M.; Rai, A.; Malla, A.B.; Wu, M.; Fiedler, D.; Mallik, R.; Bhandari, R.
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport
Biochem. J.
473
3031-3047
2016
Dictyostelium discoideum, Mus musculus (Q6PD10), Homo sapiens (Q92551), Mus musculus C57BL/6 (Q6PD10)
Manually annotated by BRENDA team
Ghosh, S.; Shukla, D.; Suman, K.; Lakshmi, B.J.; Manorama, R.; Kumar, S.; Bhandari, R.
Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels
Blood
122
1478-1486
2013
Mus musculus (Q6PD10), Mus musculus C57BL/6 (Q6PD10)
Manually annotated by BRENDA team
Jadav, R.S.; Kumar, D.; Buwa, N.; Ganguli, S.; Thampatty, S.R.; Balasubramanian, N.; Bhandari, R.
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice
Cell. Signal.
28
1124-1136
2016
Mus musculus (Q6PD10), Mus musculus
Manually annotated by BRENDA team
Wang, H.; Godage, H.Y.; Riley, A.M.; Weaver, J.D.; Shears, S.B.; Potter, B.V.
Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery
Chem. Biol.
21
689-699
2014
Homo sapiens (O43314)
Manually annotated by BRENDA team
Ghoshal, S.; Tyagi, R.; Zhu, Q.; Chakraborty, A.
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis
Int. J. Biochem. Cell Biol.
78
149-155
2016
Mus musculus (Q6PD10)
Manually annotated by BRENDA team
Ye, C.; Bandara, W.M.; Greenberg, M.L.
Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae
J. Biol. Chem.
288
24898-24908
2013
Saccharomyces cerevisiae (Q12494)
Manually annotated by BRENDA team
Yu, W.; Ye, C.; Greenberg, M.L.
Inositol hexakisphosphate kinase 1 (IP6K1) regulates inositol synthesis in mammalian cells
J. Biol. Chem.
291
10437-10444
2016
Mus musculus (Q6PD10)
Manually annotated by BRENDA team
Niger, C.; Luciotti, M.A.; Buo, A.M.; Hebert, C.; Ma, V.; Stains, J.P.
The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cdelta cascade
J. Bone Miner. Res.
28
1468-1477
2013
Mus musculus (Q6PD10), Mus musculus (Q80V72), Mus musculus (Q8BWD2)
Manually annotated by BRENDA team
Fu, C.; Xu, J.; Li, R.J.; Crawford, J.A.; Khan, A.B.; Ma, T.M.; Cha, J.Y.; Snowman, A.M.; Pletnikov, M.V.; Snyder, S.H.
Inositol hexakisphosphate kinase-3 regulates the morphology and synapse formation of cerebellar Purkinje cells via spectrin/adducin
J. Neurosci.
35
11056-11067
2015
Mus musculus (Q8BWD2)
Manually annotated by BRENDA team
Nagata, E.; Nonaka, T.; Moriya, Y.; Fujii, N.; Okada, Y.; Tsukamoto, H.; Itoh, J.; Okada, C.; Satoh, T.; Arai, T.; Hasegawa, M.; Takizawa, S.
Inositol hexakisphosphate kinase 2 promotes cell death in cells with cytoplasmic TDP-43 aggregation
Mol. Neurobiol.
53
5377-5383
2016
Homo sapiens (Q9UHH9), Homo sapiens
Manually annotated by BRENDA team
Wang, H.; DeRose, E.F.; London, R.E.; Shears, S.B.
IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family
Nat. Commun.
5
4178
2014
Entamoeba histolytica (C4M387), Entamoeba histolytica
Manually annotated by BRENDA team
Desai, M.; Rangarajan, P.; Donahue, J.L.; Williams, S.P.; Land, E.S.; Mandal, M.K.; Phillippy, B.Q.; Perera, I.Y.; Raboy, V.; Gillaspy, G.E.
Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants
Plant J.
80
642-653
2014
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Manually annotated by BRENDA team
Zhan, H.; Zhong, Y.; Yang, Z.; Xia, H.
Enzyme activities of Arabidopsis inositol polyphosphate kinases AtIPK2? and AtIPK2? are involved in pollen development, pollen tube guidance and embryogenesis.
Plant J.
82
758-771
2015
Arabidopsis thaliana (Q9FLT2), Arabidopsis thaliana (Q9LY23)
Manually annotated by BRENDA team
Rao, F.; Xu, J.; Khan, A.B.; Gadalla, M.M.; Cha, J.Y.; Xu, R.; Tyagi, R.; Dang, Y.; Chakraborty, A.; Snyder, S.H.
Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death
Proc. Natl. Acad. Sci. USA
111
16005-16010
2014
Mus musculus (Q6PD10)
Manually annotated by BRENDA team
Nair, V.; Gu, C.; Janoshazi, A.; Jessen, H.; Wang, H.; Shears, S.
Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate
Biosci. Rep.
38
BSR20171549
2018
Homo sapiens (Q6PFW1)
Manually annotated by BRENDA team
Rajasekaran, S.S.; Kim, J.; Gaboardi, G.C.; Gromada, J.; Shears, S.B.; Dos Santos, K.T.; Nolasco, E.L.; Ferreira, S.S.; Illies, C.; Koehler, M.; Gu, C.; Ryu, S.H.; Martins, J.O.; Dare, E.; Barker, C.J.; Berggren, P.O.
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic beta-cells
Cell. Signal.
46
120-128
2018
Mus musculus (Q6PD10), Homo sapiens (Q92551)
Manually annotated by BRENDA team
Gu, C.; Nguyen, H.N.; Hofer, A.; Jessen, H.J.; Dai, X.; Wang, H.; Shears, S.B.
The significance of the bifunctional kinase/phosphatase activities of diphosphoinositol pentakisphosphate kinases (PPIP5Ks) for coupling inositol pyrophosphate cell signaling to cellular phosphate homeostasis
J. Biol. Chem.
292
4544-4555
2017
Homo sapiens (O43314), Homo sapiens (Q6PFW1)
Manually annotated by BRENDA team
Wilson, M.S.; Jessen, H.J.; Saiardi, A.
The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export
J. Biol. Chem.
294
11597-11608
2019
Homo sapiens (Q92551), Homo sapiens (Q9UHH9), Homo sapiens
Manually annotated by BRENDA team
Nagpal, L.; Fu, C.; Snyder, S.H.
Inositol hexakisphosphate kinase-2 in cerebellar granule cells regulates Purkinje cells and motor coordination via protein 4.1N
J. Neurosci.
38
7409-7419
2018
Mus musculus (Q80V72)
Manually annotated by BRENDA team
Nagata, E.; Fujii, N.; Kohara, S.; Okada, C.; Satoh, T.; Takekoshi, S.; Takao, M.; Mihara, B.; Takizawa, S.
Inositol hexakisphosphate kinase 2 promotes cell death of anterior horn cells in the spinal cord of patients with myotrophic lateral sclerosis
Mol. Biol. Rep.
47
6479-6485
2020
Homo sapiens (Q9UHH9), Homo sapiens
Manually annotated by BRENDA team
Kim, M.G.; Zhang, S.; Park, H.; Park, S.J.; Kim, S.; Chung, C.
Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory
Mol. Brain
13
72
2020
Mus musculus (Q6PD10), Mus musculus
Manually annotated by BRENDA team
Yousaf, R.; Gu, C.; Ahmed, Z.M.; Khan, S.N.; Friedman, T.B.; Riazuddin, S.; Shears, S.B.; Riazuddin, S.
Mutations in diphosphoinositol-pentakisphosphate kinase PPIP5K2 are associated with hearing loss in human and mouse
PLoS Genet.
14
e1007297
2018
Homo sapiens (O43314), Homo sapiens
Manually annotated by BRENDA team
Wormald, M.; Liao, G.; Kimos, M.; Barrow, J.; Wei, H.
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity
PLoS ONE
12
e0188852
2017
Homo sapiens (Q92551), Homo sapiens
Manually annotated by BRENDA team
Fu, C.; Xu, J.; Cheng, W.; Rojas, T.; Chin, A.C.; Snowman, A.M.; Harraz, M.M.; Snyder, S.H.
Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via alpha-actinin and focal adhesion kinase
Proc. Natl. Acad. Sci. USA
114
2036-2041
2017
Mus musculus (Q6PD10)
Manually annotated by BRENDA team
Rojas, T.; Cheng, W.; Gao, Z.; Liu, X.; Wang, Y.; Malla, A.P.; Chin, A.C.; Romer, L.H.; Snyder, S.H.; Fu, C.
Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2
Proc. Natl. Acad. Sci. USA
116
3278-3287
2019
Mus musculus (Q8BWD2), Homo sapiens (Q96PC2)
Manually annotated by BRENDA team
Chin, A.; Gao, Z.; Riley, A.; Furkert, D.; Wittwer, C.; Dutta, A.; Rojas, T.; Semenza, E.; Felder, R.; Pluznick, J.; Jessen, H.; Fiedler, D.; Potter, B.; Snyder, S.; Fu, C.
The inositol pyrophosphate 5-InsP7drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85alpha
Sci. Adv.
6
eabb8542
2020
Mus musculus (Q6PD10)
Manually annotated by BRENDA team
Moritoh, Y.; Oka, M.; Yasuhara, Y.; Hozumi, H.; Iwachidow, K.; Fuse, H.; Tozawa, R.
Inositol hexakisphosphate kinase 3 regulates metabolism and lifespan in mice
Sci. Rep.
6
32072
2016
Mus musculus (Q8BWD2), Mus musculus, Homo sapiens (Q96PC2), Homo sapiens
Manually annotated by BRENDA team