2.7.4.21: inositol-hexakisphosphate 5-kinase

This is an abbreviated version!
For detailed information about inositol-hexakisphosphate 5-kinase, go to the full flat file.

Word Map on EC 2.7.4.21

2.7.4.21

pyrophosphate

polyphosphate

pp-insps

tetrakisphosphate

ppip5ks

bis-diphosphoinositol

pyrophosphorylation

5-insp7

5-diphosphoinositol

medicine

ptdins3,4,5p3

Reaction

1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate

1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Synonyms

AtIPK2alpha, AtIpk2beta, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase, AtVip1, AtVip2, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol pentakisphosphate synthetase, EC 2.7.1.152, EhIP6KA, IHPK2, inositol hexakisphosphate 5-kinase, inositol hexakisphosphate kinase, inositol hexakisphosphate kinase 1, inositol hexakisphosphate kinase 2, inositol hexakisphosphate kinase 3, inositol hexakisphosphate kinase type 2, inositol hexakisphosphate kinase-1, inositol hexakisphosphate kinase-2, inositol hexakisphosphate kinase-3, inositol polyphosphate kinase, inositol-hexakisphosphate kinase, InsP6 kinase, InsP6-kinase, InsP6K1, InsP6K2, InsP6K3, IP6 kinase, IP6 kinase 1, IP6K, IP6K1, IP6K2, IP6K3, Ipk2, IPMK, Kcs1, kinase (phosphorylating), inositol hexakisphosphate, More, Pi uptake stimulator, PiUS, PPIP5K1, PPIP5K2, RID-2

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.21 inositol-hexakisphosphate 5-kinase

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Results	in table
16	Activating Compound
20	AA Sequence
3	Application
1	CAS Registry Number
31	Cloned(Commentary)
10	Cofactor
3	Crystallization (Commentary)
179	Disease/ Diagnostics
3	Expression
97	General Information
15	IC50 Value
33	Inhibitors
2	kcat/KM [mM/s]
11	KM Value [mM]
31	Localization
10	Metals/Ions
8	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
102	Organism
1	Pathway
17	PDB ID
5	pH Optimum
1	Posttranslational Modification
36	Protein Variants
7	Purification (Commentary)
2	Reaction
4	Reaction Type
70	Reference
1	Renatured (Commentary)
104	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
63	Substrates and Products (Substrate)
13	Subunits
148	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase

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0.0128

1,3,4,5,6-inositol pentakisphosphate

Rattus norvegicus

IC50 for inositol hexakisphosphate kinase activity is 0.022 mM, IC50 for ATP synthase activity is 0.0128 mM

642551

0.00184

6-hydroxy-DL-DOPA

Homo sapiens

Q92551

pH 6.95, 37°C

762234

0.0018

diphosphoinositol pentakisphosphate

Rattus norvegicus

IC50 for inositol hexakisphosphate kinase activity is 0.0066 mM, IC50 for ATP synthase activity is 0.0018 mM

642551

0.0325

His3Cd-GST-protein

Rattus norvegicus

IC50 for inositol hexakisphosphate kinase activity is 0.061 mM, IC50 for ATP synthase activity is 0.0325 mM

642551

0.253

human skin elastin

Rattus norvegicus

IC50 for ATP synthase activity is 0.253 mM

642551

0.022

inositol 1,2,4,5,6-pentakisphosphate

Rattus norvegicus

IC50 for inositol hexakisphosphate kinase activity is 0.022 mM

642551

0.0018

Inositol hexakisphosphate

Rattus norvegicus

IC50 for inositol hexakisphosphate kinase activity is 0.0008 mM, IC50 for ATP synthase activity is 0.0018 mM

642551

0.00496

myricetin

Homo sapiens

Q92551

pH 6.95, 37°C

762234

0.0095 - 0.039

N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine

7 entries