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2.7.4.21: inositol-hexakisphosphate 5-kinase

This is an abbreviated version!
For detailed information about inositol-hexakisphosphate 5-kinase, go to the full flat file.

Word Map on EC 2.7.4.21

Reaction

ATP
+
1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
=
ADP
 +
1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Synonyms

AtIPK2alpha, AtIpk2beta, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase, AtVip1, AtVip2, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol pentakisphosphate synthetase, EC 2.7.1.152, EhIP6KA, IHPK2, inositol hexakisphosphate 5-kinase, inositol hexakisphosphate kinase, inositol hexakisphosphate kinase 1, inositol hexakisphosphate kinase 2, inositol hexakisphosphate kinase 3, inositol hexakisphosphate kinase type 2, inositol hexakisphosphate kinase-1, inositol hexakisphosphate kinase-2, inositol hexakisphosphate kinase-3, inositol polyphosphate kinase, inositol-hexakisphosphate kinase, InsP6 kinase, InsP6-kinase, InsP6K1, InsP6K2, InsP6K3, IP6 kinase, IP6 kinase 1, IP6K, IP6K1, IP6K2, IP6K3, Ipk2, IPMK, Kcs1, kinase (phosphorylating), inositol hexakisphosphate, More, Pi uptake stimulator, PiUS, PPIP5K1, PPIP5K2, RID-2

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.21 inositol-hexakisphosphate 5-kinase

Activating Compound

Activating Compound on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,5-O-benzyl-myo-inositol 1,3,4,6-tetrakisphosphate
activates the ATP hydrolysis activity and inhibits the InsP6 kinase activity of the enzyme
2-O-aminoethyl-myo-inositol 1,2,3,4,6-pentakisphosphate
-
2-O-benzoyl-myo-inositol 1,2,3,4,6-pentakisphosphate
-
2-O-benzyl-5-O-alpha-phosphonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate
stimulates ATP hydrolysis 9fold
2-O-benzyl-5-O-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate
-
2-O-benzyl-myo-inositol 1,2,3,4,6-pentakisphosphate
-
2-O-butanoyl-myo-inositol 1,2,3,4,6-pentakisphosphate
-
5-O-alpha-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate
-
5-O-alpha-phoshonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate
-
5-O-alpha-phosphonoacetyl-myo-inositol 1,2,3,4,6-pentakisphosphate
stimulates ATP hydrolysis 5fold
interferon beta
-
treatment with interferon beta enhances binding of IHPK2 to TNF receptor-associated factor 2
-
interferon-beta
-
induces IHPK2 activity after 4 h exposure
-
PtdIns(4,5)P2
increases net 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate kinase activity 5fold
-
additional information
-