2.7.4.2: phosphomevalonate kinase
This is an abbreviated version!
For detailed information about phosphomevalonate kinase, go to the full flat file.
Word Map on EC 2.7.4.2
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2.7.4.2
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isopentenyl
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isoprenoids
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diphosphomevalonate
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5-diphosphate
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mevalonate-5-pyrophosphate
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pyrophosphomevalonate
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2.7.1.36
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cholesterogenesis
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zellweger
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nonsterol
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medicine
- 2.7.4.2
-
isopentenyl
-
isoprenoids
- diphosphomevalonate
- 5-diphosphate
-
mevalonate-5-pyrophosphate
-
pyrophosphomevalonate
-
2.7.1.36
-
cholesterogenesis
-
zellweger
-
nonsterol
- medicine
Reaction
Synonyms
5-phosphomevalonate kinase, ATP:5-phosphomevalonate phosphotransferase, CcPMK, ERG8, GbPMK, kinase, phosphomevalonate (phosphorylating), mevalonate phosphate kinase, mevalonate-5-phosphate kinase, mevalonic acid phosphate kinase, More, phosphomevalonate kinase, phosphomevalonic kinase, PMK, PMVAK, PMVK, SSO2988
ECTree
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Metals Ions
Metals Ions on EC 2.7.4.2 - phosphomevalonate kinase
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Co2+
Fe2+
Mg2+
Mn2+
Zn2+
Mg2+
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maximal activity at 5 mM MgCl2, maximal activity at a Mg2+/ATP ratio of 3:1, Mn2+ and Mg2+ most effective
Mg2+
dependent on, maximal activity achieved at concentrations of 10 mM or greater
Mg2+
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ligand binding reverses the side-chain orientations of two antiparallel lysines residues 100 and 101 with the result that Lys101 is switched into a position in which its ammonium ion is in direct contact with the beta,gamma-bridging atom of the nucleotide, where it is expected to stabilize both the ground and transition states of the reaction
Mg2+
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required, Mg2+ is coordinated to the gamma-phosphoryl group of ATP in PMK
Mn2+
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preferred cation to activate the enzyme, optimal concentration about 4 mM