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2.7.4.2: phosphomevalonate kinase

This is an abbreviated version!
For detailed information about phosphomevalonate kinase, go to the full flat file.

Word Map on EC 2.7.4.2

Reaction

ATP
+
(R)-5-phosphomevalonate
=
ADP
 +
(R)-5-diphosphomevalonate

Synonyms

5-phosphomevalonate kinase, ATP:5-phosphomevalonate phosphotransferase, CcPMK, ERG8, GbPMK, kinase, phosphomevalonate (phosphorylating), mevalonate phosphate kinase, mevalonate-5-phosphate kinase, mevalonic acid phosphate kinase, More, phosphomevalonate kinase, phosphomevalonic kinase, PMK, PMVAK, PMVK, SSO2988

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.2 phosphomevalonate kinase

Inhibitors

Inhibitors on EC 2.7.4.2 - phosphomevalonate kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(R)-5-diphosphomevalonate
-
2,2',2''-(biphenyl-2,4,6-triyltrisulfanediyl)triacetate
-
2,2'-[(5,8-dihydroxy-9,10-dioxo-4a,9,9a,10-tetrahydroanthracene-1,4-diyl)diimino]bis(5-methylbenzenesulfonate)
-
3-Hydroxy-3-methyl-6-phosphohexanoic acid
-
-
4-hydroxybenzaldehyde
-
2.5 mM, 11% inhibition
4-hydroxybenzoic acid
-
2.5 mM, 28% inhibition
4-hydroxyphenylpropionic acid
-
2.5 mM, 46% inhibition
4-[(E)-(2,4-dihydroxyphenyl)diazenyl]-5-methylnaphthalene-2,7-disulfonate
-
5,5'-dithiobis(2-nitrobenzoate)
-
0.1 mM, almost complete inactivation after 5 min, phosphomevalonate partially protects, inactivation is reverted by 2-mercaptoethanol or dithiothreitol
5-diphosphomevalonate
-
-
AMP-PNP
-
competitive dead-end inhibition vs. ATP
Anisic acid
-
2.5 mM, 27% inhibition
Cinnamic acid
-
2.5 mM, 28% inhibition
isoferulic acid
-
2.5 mM, 64% inhibition
m-coumaric acid
-
2.5 mM, 70% inhibition
mevalonate
-
competitive vs. phosphomevalonate, noncompetitive vs. ATP
mevalonate 5-diphosphate
product inhibition, mutants R111M and R84M show decreased sensitivity compared to the wild-type enzyme
p-coumaric acid
-
1.25 mM, 46% inhibition
phosphomevalonate
-
-
pyridoxal 5'-phosphate
-
0.5 mM, 80% inactivation after 30 min, phosphomevalonate protects
pyridoxamine 5'-phosphate
-
0.25 mM, 60% inactivation after 20 min
vildagliptin
-
treatment reduces the hepatic expression of genes important for cholesterol synthesis and fatty acid oxidation, including phosphomevalonate kinase, acyl-coenzyme dehydrogenase medium chain, mevalonate (diphospho)decarboxylase, and acyl-CoA synthetase in wild-type, but not in dual incretin receptor knock-out mice
additional information
-