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2.7.4.15: thiamine-diphosphate kinase

This is an abbreviated version!
For detailed information about thiamine-diphosphate kinase, go to the full flat file.

Word Map on EC 2.7.4.15

Reaction

ATP
+
thiamine diphosphate
=
ADP
+
thiamine triphosphate

Synonyms

ATP:thiamin-diphosphate phosphotransferase, kinase (phosphorylating), thiamin diphosphate, kinase, thiamin diphosphate (phosphorylating), protein bound thiamin diphosphate:ATP phosphoryltransferase, TDP kinase, thiamin diphosphate kinase, thiamin diphosphate phosphotransferase, thiamin pyrophosphate kinase, thiamin-diphosphate kinase, thiamine diphosphate kinase, thiamine pyrophosphate-ATP phosphoryltransferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.15 thiamine-diphosphate kinase

Specific Activity

Specific Activity on EC 2.7.4.15 - thiamine-diphosphate kinase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
thiamine triphoshate accumulation in response to amino acid starvation, controverse mechanism of synthesis dicussed, adenylate kinase-independent accumulation of thiamine triphosphate, heat-sensitive CV2 strain of Escherichia coli accumulates thiamine triphosphate despite full inactivation of adenylate cyclase and subsequent decrease of cellular ATP, ATP-dependent mechanisms for thiamine triphosphate synthesis not favoured since large accumulation also observed during energy stress where ATP is low