2.7.4.14: UMP/CMP kinase

This is an abbreviated version!
For detailed information about UMP/CMP kinase, go to the full flat file.

Reaction

Synonyms

ATP:UMP-CMP phosphotransferase, CMP kinase, CMP/UMP kinase, CMPK, CMPK1, CMPK2, CTP:CMP phosphotransferase, cytidine monophosphate kinase, cytidine/uridine monophosphate kinase 2, cytidylate kinase, dCK, deoxycytidine kinase, EC 2.7.4.5, kinase, cytidylate (phosphorylating), More, MssA protein, nucleoside monophosphate kinase, P25, pyrimidine nucleoside monophosphate kinase, UCK, UMP-CMP kinase, UMP-CMP kinase 2, UMP-CMPK2, UMP/CMP kinase, UMP/CMP kinase 1, UMP/CMPK1, UMPK, uridine monophosphate/cytidine monophosphate kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.4 Phosphotransferases with a phosphate group as acceptor

                2.7.4.14 UMP/CMP kinase

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Results	in table
13	Activating Compound
3225	AA Sequence
3	Application
1	CAS Registry Number
12	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
112	Disease/ Diagnostics
1	Expression
9	General Information
8	General Stability
6	IC50 Value
45	Inhibitors
11	kcat/KM [mM/s]
10	Ki Value [mM]
132	KM Value [mM]
10	Localization
21	Metals/Ions
7	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
215	Organism
8	Pathway
29	PDB ID
7	pH Optimum
2	pH Range
3	pH Stability
1	pI Value
15	Protein Variants
13	Purification (Commentary)
6	Reaction
3	Reaction Type
40	Reference
1	Renatured (Commentary)
55	Source Tissue
9	Specific Activity [micromol/min/mg]
6	Storage Stability
188	Substrates and Products (Substrate)
6	Subunits
50	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
12	Temperature Stability [°C]
30	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 2.7.4.14 - UMP/CMP kinase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

20

Homo sapiens

-

in absence of glycerol, the half-life of a preparation with a specific activity of 80 is about 10 min, inactivation is partially reversed by addition of 2-mercaptoethanol

645141

25

Homo sapiens

-

30 min, stable

645146

4

2 entries

40

Homo sapiens

-

30 min, enzyme form UMPK2 loses 70% of maximal activity, enzyme form UMPK1 loses 30% of its activity

645146

45

Homo sapiens

-

30 min, enzyme form UMPK2 loses more than 80% of maximal activity, enzyme form UMPK1 loses more than 60% of its activity

645146

50

2 entries

51

Sus scrofa

-

midpoint denaturation temperature of UMP/CMP kinase

645157

52

Sus scrofa

-

midpoint denaturation temperature of the UAU chimeric enzyme

645157

58

Arabidopsis thaliana

O04905

10 min, 50% loss of activity

645153

70

Homo sapiens

P30085

inactivation of wild-type enzyme and mutant R134M enzyme, only partial denaturation of mutant P64T

739215

4

Rattus norvegicus

-

24 h, in absence of dithiothreitol the purified enzyme shows considerable loss of activity

645147

4

Saccharomyces cerevisiae

-

at pH 7 the enzyme is most stable when kept at 4°C

645149

50

Homo sapiens

-

30 min, enzyme forms UMPK2 and UMPK1 lose 90% of its activity

645146

50

Sus scrofa

-

midpoint denaturation temperature of the AUA chimeric enzyme

645157