2.7.4.14: UMP/CMP kinase

This is an abbreviated version!
For detailed information about UMP/CMP kinase, go to the full flat file.

Word Map on EC 2.7.4.14

2.7.4.14

dcmp

deoxycytidine

gemcitabine

cidofovir

nmp-binding

umpks

medicine

diagnostics

Reaction

Synonyms

ATP:UMP-CMP phosphotransferase, CMP kinase, CMP/UMP kinase, CMPK, CMPK1, CMPK2, CTP:CMP phosphotransferase, cytidine monophosphate kinase, cytidine/uridine monophosphate kinase 2, cytidylate kinase, dCK, deoxycytidine kinase, EC 2.7.4.5, kinase, cytidylate (phosphorylating), More, MssA protein, nucleoside monophosphate kinase, P25, pyrimidine nucleoside monophosphate kinase, UCK, UMP-CMP kinase, UMP-CMP kinase 2, UMP-CMPK2, UMP/CMP kinase, UMP/CMP kinase 1, UMP/CMPK1, UMPK, uridine monophosphate/cytidine monophosphate kinase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.14 UMP/CMP kinase

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Results	in table
13	Activating Compound
3225	AA Sequence
3	Application
1	CAS Registry Number
12	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
112	Disease/ Diagnostics
1	Expression
9	General Information
8	General Stability
6	IC50 Value
45	Inhibitors
11	kcat/KM [mM/s]
10	Ki Value [mM]
132	KM Value [mM]
10	Localization
21	Metals/Ions
7	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
215	Organism
8	Pathway
29	PDB ID
7	pH Optimum
2	pH Range
3	pH Stability
1	pI Value
15	Protein Variants
13	Purification (Commentary)
6	Reaction
3	Reaction Type
40	Reference
1	Renatured (Commentary)
55	Source Tissue
9	Specific Activity [micromol/min/mg]
6	Storage Stability
188	Substrates and Products (Substrate)
6	Subunits
50	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
12	Temperature Stability [°C]
30	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.7.4.14 - UMP/CMP kinase

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2-mercaptoethanol

dithiothreitol

doxorubicin

binding of doxorubicin to the enzyme (CMPK1) activates the phosphorylation of CMP, dCMP, and UMP. Doxorubicin might bind to the nonactive site of CMPK1 and regulate its activity with magnesium

glutathione

activates

L-Cys

activates

NADPH

NADPH-dependent activation system is composed of at least two protein factors: one is heat-stable and the other is indistinguishable from NADPH-dependent disulfide reductase

645144

reduced DL-alpha-lipoic acid

Rattus norvegicus

activates

645143

thioredoxin

2 entries