2.7.4.13: (deoxy)nucleoside-phosphate kinase

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For detailed information about (deoxy)nucleoside-phosphate kinase, go to the full flat file.

Reaction

Synonyms

AK, CK, deoxyadenylate monophosphate kinase, deoxycytidylate monophosphate kinase, deoxyguanylate monophosphate kinase, deoxynucleoside monophosphate kinase, deoxynucleoside-5'-monophosphate kinase, deoxyribonucleoside monophosphate kinase, deoxyribonucleoside monophosphokinase, deoxythymidylate monophosphate kinase, dNMP kinase, dNMPK, GK, kinase (phosphorylating), deoxynucleoside monophosphate, T5 bacteriophage dNMPK, TK

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.4 Phosphotransferases with a phosphate group as acceptor

                2.7.4.13 (deoxy)nucleoside-phosphate kinase

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Results	in table
115	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
1	Cofactor
1	General Information
3	Inhibitors
3	Ki Value [mM]
14	KM Value [mM]
10	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
11	Organism
10	Pathway
4	PDB ID
7	pH Optimum
4	pH Range
1	pI Value
15	Protein Variants
4	Purification (Commentary)
1	Reaction
3	Reaction Type
9	Reference
21	Specific Activity [micromol/min/mg]
3	Storage Stability
39	Substrates and Products (Substrate)
2	Subunits
19	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
4	Temperature Stability [°C]

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General Information on EC 2.7.4.13 - (deoxy)nucleoside-phosphate kinase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Tequintavirus T5

Q6QGP4

essential catalytic site residue, active site modelling, overview. The charged amino acid residues of the NMP binding domain and the presence of an OH-group at position 17 are important for the catalytic activity. Arginine residues at positions 130 and 172 are involved in the binding to the donor gamma-phosphoryl and acceptor alpha-phosphoryl groups, as well as the aspartic acid residue at position 16 of the ATP-binding site (P-loop), in the binding to some acceptors, first of all dTMP. The NMPK-P loop, or a glycine enriched loop, forms an anion hole interacting with donor phosphoryl groups. It contains a GX1X2X3X4GKX5T(S) consensus called the Walker A motif

739645