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2.7.3.2: creatine kinase

This is an abbreviated version!
For detailed information about creatine kinase, go to the full flat file.

Word Map on EC 2.7.3.2

Reaction

ATP
+
Creatine
=
ADP
 +
phosphocreatine

Synonyms

adenosine triphosphate-creatine transphosphorylase, adenosine-5'-triphosphate: creatine phosphotransferase, ATP-creatine transphosphorylase, ATP: creatine N-phosphotransferase, ATP:creatine phosphotransferase, B-type creatine kinase, BB-CK, BB-type creatine kinase, BCK, brain creatine kinase, brain type creatine kinase, brain-type CK, brain-type creatine kinase, CK, CK MM, CK-B, CK-BB, CK-MB, CK-MM, ckb, CKM, CKMB, CKMBI, CKMiMi, creatine kinase, creatine kinase B, creatine kinase M-type, creatine kinase MB, creatine kinase muscle type, creatine kinase-MB, creatine N-phosphotransferase, creatine phosphokinase, creatine phosphotransferase, creatinine kinase, creatinine kinase MB, hBBCK, hMMCK, kinase, creatine (phosphorylating), M-CK, M1-CK, MB-CK, MCK, Mi-CK, MiMi-CK, mit-CK, mitochondrial creatine kinase, MM-CK, MM-type creatine kinase, More, MtCK, muscle creatine kinase, muscle type creatine kinase, muscle-type creatine kinase, phosphocreatine kinase, plasma creatine kinase, PSCKM, recombinant human brain-type creatine kinase, rHBCK, RM-CK, s-type CK, sarcomeric CK, sMiCK, sMtCK, u-type CK, ubiquitous CK, ubiquitous MtCK, uMiCK, uMtCK, zMMCK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.3 Phosphotransferases with a nitrogenous group as acceptor
                2.7.3.2 creatine kinase

Expression

Expression on EC 2.7.3.2 - creatine kinase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
brain enzyme activity is lower on days 14 and 21 post-feeding in animals that received aflatoxin B1-contaminated diet compared to the control group
-
CKB mRNA and protein levels are significantly higher in probands affected with autosomal dominant inherited anomaly CKBE
-
cytosolic enzyme activity decreases 60% in animals infected with Aeromonas cavia compared to uninfected animals
-
cytosolic enzyme activity decreases 60% in animals infected with Aeromonas caviae compared to uninfected animals
-
high expression patterns at gastrulation and neurulation in ectoderm, high expression in somites from beginning of the tail-bud stage
high expression patterns at neurulation in somites
mitochondrial enzyme activity increases 200% in animals infected with Aeromonas caviae compared to uninfected animals
-
mutant mHTT (109Q) significantly suppresses the activity of the promoter of the CKB gene, which contributes to the lowered CKB expression in Huntington's disease. Exogenous expression of wild-type CKB, but not a dominant negative CKB mutant, rescues the phenotype