2.7.2.8: acetylglutamate kinase
This is an abbreviated version!
For detailed information about acetylglutamate kinase, go to the full flat file.
Word Map on EC 2.7.2.8
Reaction
Synonyms
acetylglutamate kinase, acetylglutamate phosphokinase, amino-acid acetyltransferase, argB, CcNAGK, EcNAGK, GRMZM2G132777, kinase, acetylglutamate (phosphorylating), mmNAGS/K, N-acetyl glutamate kinase, N-acetyl-glutamate 5-phosphotransferase, N-acetyl-L-glutamate 5-phosphotransferase, N-acetyl-L-glutamate kinase, N-acetyl-L-glutamate synthase/kinase, N-acetylglutamate 5-phosphotransferase, N-acetylglutamate kinase, N-acetylglutamate phosphokinase, N-acetylglutamate-5-phosphotransferase, N-acetylglutamic 5-phosphotransferase, NagK, NAGK1, NAGS-K, SYPA5-5 N-acetylglutamate kinase, xcNAGS/K, yNAGK
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Reference on EC 2.7.2.8 - acetylglutamate kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Baich, A.; Vogel, H.J.
N-acetyl-gamma-glutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: Repressible enzymes of arginine synthesis in Escherichia coli
Biochem. Biophys. Res. Commun.
7
491-496
1962
Escherichia coli, Escherichia coli Wc2
Abadjieva, A.; Pauwels, K.; Hilven, P.; Crabeel, M.
A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis. Acetylglutamate synthase activity requires complex formation with acetylglutamate kinase
J. Biol. Chem.
276
42869-42880
2001
Saccharomyces cerevisiae
Pauwels, K.; Abadjieva, A.; Hilven, P.; Stankiewicz, A.; Crabeel, M.
The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis
Eur. J. Biochem.
270
1014-1024
2003
Saccharomyces cerevisiae
Vogel, H.J.; McLellan, W.L.
N-Acetyl-gamma-glutamokinase (Escherichia coli)
Methods Enzymol.
17A
251-255
1970
Escherichia coli, Escherichia coli W2D / ATCC 25542
-
Farago, A.; Denes, G.
Mechanism of arginine biosynthesis in Chlamydomonas reinhardti. II. Purification and properties of N-acetylglutamate 5-phosphotransferase, the allosteric enzyme of the pathway
Biochim. Biophys. Acta
136
6-18
1967
Chlamydomonas reinhardtii
Denes, G.
N-Acetylglutamate-5-phosphotransferase
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
9
511-520
1973
Chlamydomonas reinhardtii, Escherichia coli
-
Haas, D.; Leisinger, T.
N-acetylglutamate 5-phosphotransferase of Pseudomonas aeruginosa. Purification and ligand-directed association-dissociation
Eur. J. Biochem.
52
365-375
1975
Pseudomonas aeruginosa
Haas, D.; Leisinger, T.
N-acetylglutamate 5-phosphotransferase of Pseudomonas aeruginosa. Catalytic and regulatory properties
Eur. J. Biochem.
52
377-383
1975
Pseudomonas aeruginosa
Wolf, E.C.; Weiss, R.L.
Acetylglutamate kinase. A mitochondrial feedback-sensitive enzyme of arginine biosynthesis in Neurospora crassa
J. Biol. Chem.
255
9189-9195
1980
Neurospora crassa
McKay, G.; Shargool, P.D.
Purification and characterization of N-acetylglutamate 5-phosphotransferase from pea (Pisum sativum) cotyledons
Biochem. J.
195
71-81
1981
Pisum sativum
Gil-Ortiz, F.; Ramon-Maiques, S.; Fita, I.; Rubio, V.
The course of phosphorus in the reaction of N-acetyl-L-glutamate kinase, determined from the structures of crystalline complexes, including a complex with an AlF(4)(-) transition state mimic
J. Mol. Biol.
331
231-244
2003
Escherichia coli (P0A6C8)
Fernandez-Murga, M.L.; Ramon-Maiques, S.; Gil-Ortiz, F.; Fita, I.; Rubio, V.
Towards structural understanding of feedback control of arginine biosynthesis: cloning and expression of the gene for the arginine-inhibited N-acetyl-L-glutamate kinase from Pseudomonas aeruginosa, purification and crystallization of the recombinant enzyme and preliminary X-ray studies
Acta Crystallogr. Sect. D
58
1045-1047
2002
Pseudomonas aeruginosa
Ramon-Maiques, S.; Marina, A.; Gil-Ortiz, F.; Fita, I.; Rubio, V.
Structure of acetylglutamate kinase, a key enzyme for arginine biosynthesis and a prototype for the amino acid kinase enzyme family, during catalysis
Structure
10
329-342
2002
Escherichia coli
Fernandez-Murga, M.L.; Gil-Ortiz, F.; Llacer, J.L.; Rubio, V.
Arginine biosynthesis in Thermotoga maritima: characterization of the arginine-sensitive N-acetyl-L-glutamate kinase
J. Bacteriol.
186
6142-6149
2004
Pseudomonas aeruginosa, Thermotoga maritima
Maheswaran, M.; Urbanke, C.; Forchhammer, K.
Complex formation and catalytic activation by the PII signaling protein of N-acetyl-L-glutamate kinase from Synechococcus elongatus strain PCC 7942
J. Biol. Chem.
279
55202-55210
2004
Synechococcus elongatus
Marco-Marin, C.; Ramon-Maiques, S.; Tavarez, S.; Rubio, V.
Site-directed mutagenesis of Escherichia coli acetylglutamate kinase and aspartokinase III probes the catalytic and substrate-binding mechanisms of these amino acid kinase family enzymes and allows three-dimensional modelling of aspartokinase
J. Mol. Biol.
334
459-476
2003
Escherichia coli (P0A6C8), Escherichia coli
Sugiyama, K.; Hayakawa, T.; Kudo, T.; Ito, T.; Yamaya, T.
Interaction of N-acetylglutamate kinase with a PII-like protein in rice
Plant Cell Physiol.
45
1768-1778
2004
Oryza sativa
Shi, D.; Caldovic, L.; Jin, Z.; Yu, X.; Qu, Q.; Roth, L.; Morizono, H.; Hathout, Y.; Allewell, N.M.; Tuchman, M.
Expression, crystallization and preliminary crystallographic studies of a novel bifunctional N-acetylglutamate synthase/kinase from Xanthomonas campestris homologous to vertebrate N-acetylglutamate synthase
Acta Crystallogr. Sect. F
F62
1218-1222
2006
Xanthomonas campestris (Q8P8J6)
Qu, Q.; Morizono, H.; Shi, D.; Tuchman, M.; Caldovic, L.
A novel bifunctional N-acetylglutamate synthase-kinase from Xanthomonas campestris that is closely related to mammalian N-acetylglutamate synthase
BMC Biochem.
8
4
2007
Xanthomonas campestris (Q8P8J6), Xanthomonas campestris
Ferrario-Mery, S.; Besin, E.; Pichon, O.; Meyer, C.; Hodges, M.
The regulatory PII protein controls arginine biosynthesis in Arabidopsis
FEBS Lett.
580
2015-2020
2006
Arabidopsis thaliana (Q9SCL7)
Chen, Y.M.; Ferrar, T.S.; Lohmeir-Vogel, E.; Morrice, N.; Mizuno, Y.; Berenger, B.; Ng, K.K.; Muench, D.G.; Moorhead, G.B.
The PII signal transduction protein of Arabidopsis thaliana forms an arginine-regulated complex with plastid N-acetyl glutamate kinase
J. Biol. Chem.
281
5726-5733
2006
Arabidopsis thaliana (Q9SCL7), Arabidopsis thaliana
Mizuno, Y.; Moorhead, G.B.; Ng, K.K.
Structural basis for the regulation of N-acetylglutamate kinase by PII in Arabidopsis thaliana
J. Biol. Chem.
282
35733-35740
2007
Arabidopsis thaliana, Arabidopsis thaliana (Q9SCL7)
Ramon-Maiques, S.; Fernandez-Murga, M.L.; Gil-Ortiz, F.; Vagin, A.; Fita, I.; Rubio, V.
Structural bases of feed-back control of arginine biosynthesis, revealed by the structures of two hexameric N-acetylglutamate kinases, from Thermotoga maritima and Pseudomonas aeruginosa
J. Mol. Biol.
356
695-713
2006
Pseudomonas aeruginosa (Q9HTN2), Pseudomonas aeruginosa, Thermotoga maritima (Q9X2A4), Thermotoga maritima
Llacer, J.L.; Contreras, A.; Forchhammer, K.; Marco-Marin, C.; Gil-Ortiz, F.; Maldonado, R.; Fita, I.; Rubio, V.
The crystal structure of the complex of PII and acetylglutamate kinase reveals how PII controls the storage of nitrogen as arginine
Proc. Natl. Acad. Sci. USA
104
17644-17649
2007
Synechococcus elongatus (Q6V1L5), Synechococcus elongatus
Wu, C.W.; Li, L.F.; Liu, X.; Gao, X.Z.; Lei, J.; Su, X.D.; Zhao, X.; Liang, Y.H.
Protein preparation, crystallization and preliminary X-ray crystallographic analysis of N-acetylglutamate kinase from Streptococcus mutans
Protein Pept. Lett.
15
541-543
2008
Streptococcus mutans
Fernandez-Murga, M.L.; Rubio, V.
Basis of arginine sensitivity of microbial N-acetyl-L-glutamate kinases: mutagenesis and protein engineering study with the Pseudomonas aeruginosa and Escherichia coli enzymes
J. Bacteriol.
190
3018-3025
2008
Pseudomonas aeruginosa
Feria Bourrellier, A.; Ferrario-Méry, S.; Vidal, J.; Hodges, M.
Metabolite regulation of the interaction between Arabidopsis thaliana PII and N-acetyl-l-glutamate kinase
Biochem. Biophys. Res. Commun.
387
700-704
2009
Arabidopsis thaliana
Min, L.; Jin, Z.; Caldovic, L.; Morizono, H.; Allewell, N.M.; Tuchman, M.; Shi, D.
Mechanism of allosteric inhibition of N-acetyl-L-glutamate synthase by L-arginine
J. Biol. Chem.
284
4873-4880
2009
Arabidopsis thaliana, Pseudomonas aeruginosa (Q9HTN2)
Beez, S.; Fokina, O.; Herrmann, C.; Forchhammer, K.
N-acetyl-L-glutamate kinase (NAGK) from oxygenic phototrophs: P(II) signal transduction across domains of life reveals novel insights in NAGK control
J. Mol. Biol.
389
748-758
2009
Synechococcus elongatus, Arabidopsis thaliana (Q9SCL7), Arabidopsis thaliana
Shi, D.; Li, Y.; Cabrera-Luque, J.; Jin, Z.; Yu, X.; Zhao, G.; Haskins, N.; Allewell, N.M.; Tuchman, M.
A novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris
PLoS ONE
6
e28825
2011
Maricaulis maris
Xu, M.; Rao, Z.; Dou, W.; Yang, J.; Jin, J.; Xu, Z.
Site-directed mutagenesis and feedback-resistant N-acetyl-L-glutamate kinase (NAGK) increase Corynebacterium crenatum L-arginine production
Amino Acids
43
255-266
2012
Corynebacterium crenatum
Xu, M.; Rao, Z.; Dou, W.; Jin, J.; Xu, Z.
Site-directed mutagenesis studies on the L-arginine-binding sites of feedback inhibition in N-acetyl-L-glutamate kinase (NAGK) from Corynebacterium glutamicum
Curr. Microbiol.
64
164-172
2012
Corynebacterium glutamicum
Fokina, O.; Chellamuthu, V.R.; Zeth, K.; Forchhammer, K.
A novel signal transduction protein P(II) variant from Synechococcus elongatus PCC 7942 indicates a two-step process for NAGK-P(II) complex formation
J. Mol. Biol.
399
410-421
2010
Synechococcus elongatus
Gil-Ortiz, F.; Ramon-Maiques, S.; Fernandez-Murga, M.L.; Fita, I.; Rubio, V.
Two crystal structures of Escherichia coli N-acetyl-L-glutamate kinase demonstrate the cycling between open and closed conformations
J. Mol. Biol.
399
476-490
2010
Escherichia coli (A0A140NEG9), Escherichia coli
Marcos, E.; Crehuet, R.; Bahar, I.
Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members
PLoS Comput. Biol.
7(9)
e1002201
2011
Escherichia coli
de Cima, S.; Gil-Ortiz, F.; Crabeel, M.; Fita, I.; Rubio, V.
Insight on an arginine synthesis metabolon from the tetrameric structure of yeast acetylglutamate kinase
PLoS ONE
7
e34734
2012
Saccharomyces cerevisiae (Q01217), Saccharomyces cerevisiae
Van de Casteele, M.; Demarez, M.; Legrain, C.; Glansdorff, N.; Pierard, A.
Pathways of arginine biosynthesis in extreme thermophilic archaeo- and eubacteria
J. Gen. Microbiol.
136
1177-1183
1990
Saccharolobus solfataricus, Saccharolobus solfataricus P1
-
Zhao, G.; Haskins, N.; Jin, Z.; M Allewell, N.; Tuchman, M.; Shi, D.
Structure of N-acetyl-L-glutamate synthase/kinase from Maricaulis maris with the allosteric inhibitor L-arginine bound
Biochem. Biophys. Res. Commun.
437
585-590
2013
Maricaulis maris (Q0ASS9), Maricaulis maris, Maricaulis maris MCS10 (Q0ASS9), Xanthomonas campestris (A0A0H2X8L7), Xanthomonas campestris 8004 (A0A0H2X8L7)
Zhao, Q.; Luo, Y.; Dou, W.; Zhang, X.; Zhang, X.; Zhang, W.; Xu, M.; Geng, Y.; Rao, Z.; Xu, Z.
Controlling the transcription levels of argGH redistributed L-arginine metabolic flux in N-acetylglutamate kinase and ArgR-deregulated Corynebacterium crenatum
J. Ind. Microbiol. Biotechnol.
43
55-66
2016
Corynebacterium crenatum (Q6R6P5), Corynebacterium crenatum, Corynebacterium crenatum SYPA5-5 (Q6R6P5), Corynebacterium crenatum SYPA5-5
Yang, X.
Conformational dynamics play important roles upon the function of N-acetylglutamate kinase
Appl. Microbiol. Biotechnol.
101
3485-3492
2017
Escherichia coli (P0A6C8), Corynebacterium glutamicum (Q59281), Pseudomonas aeruginosa (Q9HTN2), Thermotoga maritima (Q9X2A4), Corynebacterium glutamicum ATCC 13032 (Q59281)
Liu, W.; Xiang, Y.; Zhang, X.; Han, G.; Sun, X.; Sheng, Y.; Yan, J.; Scheller, H.V.; Zhang, A.
Over-expression of a maize N-acetylglutamate kinase gene (ZmNAGK) improves drought tolerance in tobacco
Front. Plant Sci.
9
1902
2018
Zea mays (A0A1D6E3W6), Zea mays
Zhao, Q.; Luo, Y.; Dou, W.; Zhang, X.; Zhang, X.; Zhang, W.; Xu, M.; Geng, Y.; Rao, Z.; Xu, Z.
Controlling the transcription levels of argGH redistributed L-arginine metabolic flux in N-acetylglutamate kinase and ArgR-deregulated Corynebacterium crenatum
J. Ind. Microbiol. Biotechnol.
43
55-66
2016
Corynebacterium crenatum, Corynebacterium crenatum SYPA5-5
Huang, J.; Chen, D.; Yan, H.; Xie, F.; Yu, Y.; Zhang, L.; Sun, M.; Peng, X.
Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana
J. Integr. Plant Biol.
59
642-656
2017
Arabidopsis thaliana (Q9SCL7), Arabidopsis thaliana
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