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2.7.1.B26: aminoglycoside 3'-phosphotransferase

This is an abbreviated version!
For detailed information about aminoglycoside 3'-phosphotransferase, go to the full flat file.

Word Map on EC 2.7.1.B26

Reaction

GTP
+
gentamicin JI-20A
=
GDP
 +
gentamicin JI-20A 3'-phosphate

Synonyms

aminoglycoside 3'-phosphotransferase VIII, APH(3'), APH-3'-IIIa, Aph3, APHVIII, biosynthetic aminoglycoside 3'-phosphotransferase, GnTI

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.B26 aminoglycoside 3'-phosphotransferase

Substrates Products

Substrates Products on EC 2.7.1.B26 - aminoglycoside 3'-phosphotransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + amikacin
ADP + amikacin 3'-phosphate
show the reaction diagram
-
-
-
?
ATP + kanamycin A
ADP + kanamycin A 3'-phosphate
show the reaction diagram
-
-
-
?
ATP + neomycin B
ADP + neomycin B 3'-phosphate
show the reaction diagram
-
-
-
?
GTP + 1-deaminoneamine
GDP + 1-deaminoneamine 3'-phosphate
show the reaction diagram
-
-
-
?
GTP + 2'-deaminoneamine
GDP + 2'-deaminoneamine 3'-phosphate
show the reaction diagram
-
-
-
?
GTP + 3-deaminoneamine
GDP + 3-deaminoneamine 3'-phosphate
show the reaction diagram
-
-
-
?
GTP + 6'-deaminoneamine
GDP + 6'-deaminoneamine 3'-phosphate
show the reaction diagram
-
-
-
?
GTP + amikacin
GDP + amikacin 3'-phosphate
show the reaction diagram
GTP + gentamicin JI-20A
GDP + gentamicin JI-20A 3'-phosphate
show the reaction diagram
GTP + kanamycin A
GDP + kanamycin A 3'-phosphate
show the reaction diagram
GTP + kanamycin B
GDP + kanamycin B 3'-phosphate
show the reaction diagram
GTP + neamine
GDP + neamine 3'-phosphate
show the reaction diagram
-
-
-
?
GTP + neomycin B
GDP + neomycin B 3'-phosphate
show the reaction diagram
additional information
?
-
an amino group on C-1 and either an amino or a hydroxyl group at the 2' and 6' positions are important for detoxification of aminoglycosides by the enzyme
-
-
?