2.7.1.B19: geranylgeraniol kinase
This is an abbreviated version!
For detailed information about geranylgeraniol kinase, go to the full flat file.
Reaction
Synonyms
GGOH kinase
ECTree
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Substrates Products
Substrates Products on EC 2.7.1.B19 - geranylgeraniol kinase
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REACTION DIAGRAM
ATP + (2E,6E)-farnesol
ADP + (2E,6E)-farnesyl phosphate
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7% of the activity compared to all-trans-geranylgeraniol. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes
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ATP + all-trans-hexaprenol
ADP + all-trans-hexaprenyl phosphate
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38% of the activity compared to all-trans-geranylgeraniol. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes
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-
?
ATP + all-trans-octaprenol
ADP + all-trans-octaprenyl phosphate
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24% of the activity compared to all-trans-geranylgeraniol. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes
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?
CTP + geranylgeraniol
CDP + geranylgeranyl phosphate
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63% of the activity compared to ATP. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes
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?
GTP + geranylgeraniol
GDP + geranylgeranyl phosphate
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87% of the activity compared to ATP. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes
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?
UTP + geranylgeraniol
UDP + geranylgeranyl phosphate
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76% of the activity compared to ATP. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes
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?
additional information
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neither geraniol nor (22E,6E,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z)-undecaprenol are active as substrates
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ADP + geranylgeranyl phosphate
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all-trans-geranylgeraniol seems to be converted to its monophosphate in the membrane, and this product moves to the cytosol to undergo a second phosphorylation
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ATP + geranylgeraniol
ADP + geranylgeranyl phosphate
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all-trans-geranylgeraniol and ATP are the best substrates, activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes. No formation of geranylgeranyl diphosphate is observed
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