2.7.1.91: sphingosine kinase
This is an abbreviated version!
For detailed information about sphingosine kinase, go to the full flat file.
Word Map on EC 2.7.1.91
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2.7.1.91
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sphingosine-1-phosphate
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1-phosphate
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sphingolipids
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ceramide
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endothelial
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sirnas
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necrosis
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agonist
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metastasis
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artery
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erk
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phospholipase
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fingolimod
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fibrosis
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lymphocyte
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protein-coupled
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sphingomyelinase
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tnf
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pulmonary
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leukemia
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sphingomyelin
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anti-apoptotic
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s1p-induced
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stat3
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pertussis
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mapks
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pro-apoptotic
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mitogen
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sclerosis
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pkc
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rheostat
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signal-regulated
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caspase-3
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pro-survival
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platelet-derived
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lysophospholipids
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cardioprotective
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phytosphingosine
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drug development
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lymphopenia
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egress
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glucosylceramide
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medicine
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fumonisins
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s1p-mediated
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dihydroceramide
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mitogenesis
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pdgf-induced
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ceramide-induced
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lysophosphatidic
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fcepsilonri
- 2.7.1.91
- sphingosine-1-phosphate
- 1-phosphate
- sphingolipids
- ceramide
- endothelial
- sirnas
- necrosis
- agonist
- metastasis
- artery
- erk
- phospholipase
- fingolimod
- fibrosis
- lymphocyte
-
protein-coupled
- sphingomyelinase
- tnf
- pulmonary
- leukemia
- sphingomyelin
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anti-apoptotic
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s1p-induced
- stat3
- pertussis
- mapks
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pro-apoptotic
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mitogen
- sclerosis
- pkc
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rheostat
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signal-regulated
- caspase-3
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pro-survival
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platelet-derived
- lysophospholipids
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cardioprotective
- phytosphingosine
- drug development
- lymphopenia
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egress
- glucosylceramide
- medicine
- fumonisins
-
s1p-mediated
- dihydroceramide
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mitogenesis
-
pdgf-induced
-
ceramide-induced
-
lysophosphatidic
- fcepsilonri
Reaction
Synonyms
dihydrosphingosine kinase, kinase, dihydrosphingosine (phosphorylating), kinase, sphingosine (phosphorylating), More, SGK, SK, SK-1, SK-2, SK1, SK2, sphinganine kinase, sphingoid base kinase, sphingosine kinase, sphingosine kinase 1, sphingosine kinase 2, sphingosine kinase type 1, sphingosine kinase type 2, sphingosine kinase-1, sphingosine kinase-2, SPHK, SPHK-1, SPHK1, SPHK1a, SPHK1b, SPHK2, SPK
ECTree
2.7.1.91 sphingosine kinaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 2.7.1.91 - sphingosine kinase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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gracilis muscle resistance artery. Pressure-dependent activation and translocation of isoform Sk1 by ERK1/2 is critically dependent on its serine225 phosphorylation site
the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound
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gracilis muscle resistance artery. Pressure-dependent activation and translocation of isoform Sk1 by ERK1/2 is critically dependent on its serine225 phosphorylation site
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SPHK1, exclusively in the acrosome, spermatozoa contain 5 sphingosine 1-phosphate receptors
additional information
higher activity of isozyme SPHK1, low activity of isozyme SPHK2
higher activity of isozyme SPHK1, low activity of isozyme SPHK2
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in bronchial epithelial cells, SphK1 and MUC5AC expression is increased by IL-13 treatment at both protein and mRNA levels, whereas SphK2 expression is not changed
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in airway epithelium of a mouse asthmatic model, both SphK and MUC5AC expression are increased and proteins co-localize
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SPHK2 is expressed in the synovial fibroblasts of the synovial tissues obtained from the knee joints of rheumatiod patients. In the cultured synovial fibroblasts from these patients, SPHK2 is more highly expressed than that in the human macrophage cell line, THP-1 and human dermal fibroblasts. SPHK2 is expressed in and around the nucleus and transferred to the cytoplasm and cell surface by the administration of epidermal growth factor, associated with the increased expression of sphingosine 1-phosphate. A sphingosine analogue, FTY720, which is activated by phosphorylation specifically by SPHK2, mediates apoptotic signaling of the cultured synovial fibroblasts
high activity of isozyme SPHK2, low activity of isozyme SPHK1
high activity of isozyme SPHK1, low activity of isozyme SPHK2
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from bone marrow. N,N-dimethyl-D-erythro-sphingosine inhibits osteoclastogenesis a sphingosine kinase independently of sphingosine kinase
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during gestation, isoforms Sphk1 and Sphk2 are co-expressed. The levels and activity of SphK1/2 are modest at midgestation , increase at day 19 and progressively decline to low at postpartum. Inhibition of protein kinase C and ERK reduces SphK1/2 activity. In primary cultures of myometrial cells from day 19 pregnant rats, induction of COX2 is mediated by 4-phorbol 12,13-dibutyrate and IL-1 through sequential activation of protein kinase C, ERK1/2, and SphK1. Sphingosine 1-phosphate produced by SphK1 is released in the medium. In day 12 myometrial tissues, the release of sphingosine 1-phosphate is markedly reduced in association with low levels of SphK1 and COX2
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sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells
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in the cultured synovial fibroblasts from rheumatoid arthritis patients, SPHK2 is more highly expressed than in the human macrophage cell line, THP-1 and human dermal fibroblasts
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epidermal growth factor regulates plasminogen activator inhibitor-1 by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells
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N,N-dimethyl-D-erythro-sphingosine induces apoptotic cell death via modulation of mitochondrial membrane potential, c-Jun N-terminal protein kinase, p38 MAP kinase, extracellular signal-regulated kinase, and Akt kinase, but not through inhibition of sphingosine kinase or protein -kinase C in U937 cells
additional information
the 2 genes Sk1 and Sk2 show overlapping but distinct temporal and spatial expression patterns
additional information
the 2 genes Sk1 and Sk2 show overlapping but distinct temporal and spatial expression patterns
additional information
tissue distribution of isozyme SPHK1 and isozyme SPHK2 expression and activity, overview
additional information
tissue distribution of isozyme SPHK1 and isozyme SPHK2 expression and activity, overview
additional information
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tissue distribution of isozyme SPHK1 and isozyme SPHK2 expression and activity, overview
