2.7.1.91: sphingosine kinase
This is an abbreviated version!
For detailed information about sphingosine kinase, go to the full flat file.
Word Map on EC 2.7.1.91
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2.7.1.91
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sphingosine-1-phosphate
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1-phosphate
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sphingolipids
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ceramide
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endothelial
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sirnas
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necrosis
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agonist
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metastasis
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artery
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erk
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phospholipase
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fingolimod
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fibrosis
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lymphocyte
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protein-coupled
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sphingomyelinase
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tnf
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pulmonary
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leukemia
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sphingomyelin
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anti-apoptotic
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s1p-induced
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stat3
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pertussis
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mapks
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pro-apoptotic
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mitogen
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sclerosis
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pkc
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rheostat
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signal-regulated
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caspase-3
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pro-survival
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platelet-derived
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lysophospholipids
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cardioprotective
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phytosphingosine
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drug development
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lymphopenia
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egress
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glucosylceramide
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medicine
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fumonisins
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s1p-mediated
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dihydroceramide
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mitogenesis
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pdgf-induced
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ceramide-induced
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lysophosphatidic
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fcepsilonri
- 2.7.1.91
- sphingosine-1-phosphate
- 1-phosphate
- sphingolipids
- ceramide
- endothelial
- sirnas
- necrosis
- agonist
- metastasis
- artery
- erk
- phospholipase
- fingolimod
- fibrosis
- lymphocyte
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protein-coupled
- sphingomyelinase
- tnf
- pulmonary
- leukemia
- sphingomyelin
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anti-apoptotic
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s1p-induced
- stat3
- pertussis
- mapks
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pro-apoptotic
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mitogen
- sclerosis
- pkc
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rheostat
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signal-regulated
- caspase-3
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pro-survival
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platelet-derived
- lysophospholipids
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cardioprotective
- phytosphingosine
- drug development
- lymphopenia
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egress
- glucosylceramide
- medicine
- fumonisins
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s1p-mediated
- dihydroceramide
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mitogenesis
-
pdgf-induced
-
ceramide-induced
-
lysophosphatidic
- fcepsilonri
Reaction
Synonyms
dihydrosphingosine kinase, kinase, dihydrosphingosine (phosphorylating), kinase, sphingosine (phosphorylating), More, SGK, SK, SK-1, SK-2, SK1, SK2, sphinganine kinase, sphingoid base kinase, sphingosine kinase, sphingosine kinase 1, sphingosine kinase 2, sphingosine kinase type 1, sphingosine kinase type 2, sphingosine kinase-1, sphingosine kinase-2, SPHK, SPHK-1, SPHK1, SPHK1a, SPHK1b, SPHK2, SPK
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Natural Substrates Products
Natural Substrates Products on EC 2.7.1.91 - sphingosine kinase
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REACTION DIAGRAM
ATP + dihydrosphingosine
ADP + dihydrosphingosine 1-phosphate
C14 and C16 dihydrosphingosine substrates
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-
?
ATP + D-erythro-sphingosine
ADP + D-erythro-sphingosine 1-phosphate
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-
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?
ATP + D-erythro-sphingosine
ADP + D-erythro-sphingosine 1-phosphate
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-
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?
ATP + D-erythro-sphingosine
ADP + D-erythro-sphingosine 1-phosphate
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major substrate of isozyme SPHK1, also active with isozyme SPHK2
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?
ATP + D-erythro-sphingosine
ADP + D-erythro-sphingosine 1-phosphate
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-
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?
ADP + phytosphingosine 1-phosphate
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phytosphingosine 1-phosphate is capable of regulating the turgor in guard cells/stomatal aperture via G-proteins
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ir
ATP + sphinganine
ADP + sphinganine 1-phosphate
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involved in signal transduction in the nucleus
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?
ATP + sphinganine
ADP + sphinganine 1-phosphate
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the lipid phosphate acts as a pleiotropic agent in cell signalling pathways, acts often in concert with ceramide 1-phosphate, enzyme is involved in the sphingomyelid pathway, overview
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?
ATP + sphinganine
ADP + sphinganine 1-phosphate
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overview on cellular functions
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?
ATP + sphinganine
ADP + sphinganine 1-phosphate
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involved in regulation of GTP cyclohydrolase I and 6(r)-5,6,7,8-tetrahydrobiopterin
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?
ATP + sphinganine
ADP + sphinganine 1-phosphate
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the lipid phosphate acts as a pleiotropic agent in cell signalling pathways, enzyme is involved in the sphingomyelid pathway, overview
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?
ATP + sphinganine
ADP + sphinganine 1-phosphate
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D-erythro-sphinganine, sphingosine metabolism
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?
ATP + sphinganine
ADP + sphinganine 1-phosphate
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calcium mobilization through antigen receptors utilizes enzyme
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?
ATP + sphinganine
ADP + sphinganine 1-phosphate
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overview on cellular functions
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?
ADP + sphingosine 1-phosphate
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sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview
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ir
ATP + sphingosine
ADP + sphingosine 1-phosphate
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sphingosine 1-phosphate is capable of regulating the turgor in guard cells/stomatal aperture via G-proteins
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ir
ATP + sphingosine
ADP + sphingosine 1-phosphate
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sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview
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ir
ATP + sphingosine
ADP + sphingosine 1-phosphate
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sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview
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ir
ATP + sphingosine
ADP + sphingosine 1-phosphate
C14 and C16 sphingosine substrates
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?
ATP + sphingosine
ADP + sphingosine 1-phosphate
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sphingosine 1-phosphate is a mediator in diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis
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?
ATP + sphingosine
ADP + sphingosine 1-phosphate
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sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview
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ir
ATP + sphingosine
ADP + sphingosine 1-phosphate
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sphingosine is a modulator of membrane signal transduction systems and a regulatory element of cardiac and skeletal muscle physiology
sphingosine 1-phosphate is a intracellular messenger molecule and ann extracellular ligand for specific membrane receptors
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?
ATP + sphingosine
ADP + sphingosine 1-phosphate
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short-living product S1P is a bioactive lipid mediator in diverse cellular processes, e.g. regulation of cell differentiation, motility, and apoptosis both extracellularly via S1P family receptors and intracellularly
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?
ATP + sphingosine
ADP + sphingosine 1-phosphate
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sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview
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ir
ATP + sphingosine
ADP + sphingosine 1-phosphate
involved in diverse biological functions
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?
ATP + sphingosine
ADP + sphingosine 1-phosphate
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sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview
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ir
ATP + sphingosine
ADP + sphingosine 1-phosphate
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sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview
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ir
?
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sphingosine 1-phosphate is responsible for resistance to the anticancer drug cisplatin
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?
additional information
?
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requirement for Sk2 in normal reproductive function, product S1P signaling promotes cell proliferation, survival, and migration, enzyme reduces cellular levels of sphingosine and ceramide, sphingolipid metabolism, overview
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?
additional information
?
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requirement for Sk2 in normal reproductive function, product S1P signaling promotes cell proliferation, survival, and migration, enzyme reduces cellular levels of sphingosine and ceramide, sphingolipid metabolism, overview
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?
additional information
?
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isozyme SPHK1 is involved in responses to macrophages, the enzyme is involved in mast cell signalling, in neutrophil priming, and in prostaglandin biosynthesis via arachidonic acid production, overview, sphinganine 1-phosphate acts as an extracellular mediator by binding to specific members of the EDG-family of G-protein coupled receptors, and intracellularly as a messenger
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?
additional information
?
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sphingosine and sphingosine 1-phosphate activate phospholipase D in mouse myoblasts
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additional information
?
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the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation and via neutrophil, macrophage, and monocyte activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis, chemotaxis of leukocytes
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?
additional information
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the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound
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?
additional information
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the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound
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?
additional information
?
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the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound
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?
additional information
?
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sphinganine 1-phosphate acts as an extracellular mediator by binding to specific members of the EDG-family of G-protein coupled receptors, and intracellularly as a messenger
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?
additional information
?
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the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis
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?
additional information
?
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sphingosine kinase-mediated signalling plays a role in the innate and adaptive immune responses by altering migration of dendritic cells
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?
additional information
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long-rSK1 is involved in cell signaling
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?