2.7.1.91: sphingosine kinase
This is an abbreviated version!
For detailed information about sphingosine kinase, go to the full flat file.
Word Map on EC 2.7.1.91
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2.7.1.91
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sphingosine-1-phosphate
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1-phosphate
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sphingolipids
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ceramide
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endothelial
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sirnas
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necrosis
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agonist
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metastasis
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artery
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erk
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phospholipase
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fingolimod
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fibrosis
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lymphocyte
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protein-coupled
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sphingomyelinase
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tnf
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pulmonary
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leukemia
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sphingomyelin
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anti-apoptotic
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s1p-induced
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stat3
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pertussis
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mapks
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pro-apoptotic
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mitogen
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sclerosis
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pkc
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rheostat
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signal-regulated
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caspase-3
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pro-survival
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platelet-derived
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lysophospholipids
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cardioprotective
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phytosphingosine
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drug development
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lymphopenia
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egress
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glucosylceramide
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medicine
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fumonisins
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s1p-mediated
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dihydroceramide
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mitogenesis
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pdgf-induced
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ceramide-induced
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lysophosphatidic
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fcepsilonri
- 2.7.1.91
- sphingosine-1-phosphate
- 1-phosphate
- sphingolipids
- ceramide
- endothelial
- sirnas
- necrosis
- agonist
- metastasis
- artery
- erk
- phospholipase
- fingolimod
- fibrosis
- lymphocyte
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protein-coupled
- sphingomyelinase
- tnf
- pulmonary
- leukemia
- sphingomyelin
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anti-apoptotic
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s1p-induced
- stat3
- pertussis
- mapks
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pro-apoptotic
-
mitogen
- sclerosis
- pkc
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rheostat
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signal-regulated
- caspase-3
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pro-survival
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platelet-derived
- lysophospholipids
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cardioprotective
- phytosphingosine
- drug development
- lymphopenia
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egress
- glucosylceramide
- medicine
- fumonisins
-
s1p-mediated
- dihydroceramide
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mitogenesis
-
pdgf-induced
-
ceramide-induced
-
lysophosphatidic
- fcepsilonri
Reaction
Synonyms
dihydrosphingosine kinase, kinase, dihydrosphingosine (phosphorylating), kinase, sphingosine (phosphorylating), More, SGK, SK, SK-1, SK-2, SK1, SK2, sphinganine kinase, sphingoid base kinase, sphingosine kinase, sphingosine kinase 1, sphingosine kinase 2, sphingosine kinase type 1, sphingosine kinase type 2, sphingosine kinase-1, sphingosine kinase-2, SPHK, SPHK-1, SPHK1, SPHK1a, SPHK1b, SPHK2, SPK
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Localization
Localization on EC 2.7.1.91 - sphingosine kinase
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enzymes cycles between trans-Golgi network and late endosomes, facing the cytosol
additional information
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SPHK2 is expressed in and around the nucleus and transferred to the cytoplasm and cell surface by the administration of epidermal growth factor, associated with the increased expression of sphingosine 1-phosphate
isozyme SphK1 is mostly in the cytoplasm and migrates to the plasma membrane upon phosphorylation
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the cytosolic enzyme is 20fold less active than the membrane-associated enzyme
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enzymes cycles between trans-Golgi network and late endosomes, facing the cytosol
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75% of total activity in leaves, associated with, the cytosolic enzyme is 20fold less active than the membrane-associated enzyme
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deleting the N-terminal domain with residues 1-175 reduces Sphk2 membrane localisation in cells
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SPHK2 is expressed in and around the nucleus and transferred to the cytoplasm and cell surface by the administration of epidermal growth factor, associated with the increased expression of sphingosine 1-phosphate
isozyme SK2 possess (and isozyme SK1 lacks) nuclear localization R88-R93 and export signal sequences L380-L389 that help to define subcellular localization and function
isozyme SphK1 is mostly in the cytoplasm and migrates to the plasma membrane upon phosphorylation
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activation of Gq protein-coupled receptors induces a profound, rapid and long-lasting translocation of isoform SphK1 to the plasma membrane
additional information
isozyme hSK1 lacks the nuclear localization R88-R93 and export signal sequences, in contrast to isozyme hSK2. Threonine 54 and asparagine 89 are required for the specific increase in affinity of hSK1 with vesicles comprised of phosphatidylcholine and phosphatidylserine over those comprised of phosphatidylcholine and phosphatidylglycerol. Mutants T54A and N89A lose selective binding to POPC/POPS over POPC/POPG, whereas the S168A mutant maintain the selectivity shown by WT
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additional information
isozyme hSK1 lacks the nuclear localization R88-R93 and export signal sequences, in contrast to isozyme hSK2. Threonine 54 and asparagine 89 are required for the specific increase in affinity of hSK1 with vesicles comprised of phosphatidylcholine and phosphatidylserine over those comprised of phosphatidylcholine and phosphatidylglycerol. Mutants T54A and N89A lose selective binding to POPC/POPS over POPC/POPG, whereas the S168A mutant maintain the selectivity shown by WT
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additional information
unlike isozyme SK1, isozyme SK2 does not translocate the membrane fraction following calmodulin binding
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additional information
unlike isozyme SK1, isozyme SK2 does not translocate the membrane fraction following calmodulin binding
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