Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.1.91: sphingosine kinase

This is an abbreviated version!
For detailed information about sphingosine kinase, go to the full flat file.

Word Map on EC 2.7.1.91

Reaction

ATP
+
a sphingoid base
=
ADP
 +
a sphingoid base 1-phosphate

Synonyms

dihydrosphingosine kinase, kinase, dihydrosphingosine (phosphorylating), kinase, sphingosine (phosphorylating), More, SGK, SK, SK-1, SK-2, SK1, SK2, sphinganine kinase, sphingoid base kinase, sphingosine kinase, sphingosine kinase 1, sphingosine kinase 2, sphingosine kinase type 1, sphingosine kinase type 2, sphingosine kinase-1, sphingosine kinase-2, SPHK, SPHK-1, SPHK1, SPHK1a, SPHK1b, SPHK2, SPK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.91 sphingosine kinase

KI Value

KI Value on EC 2.7.1.91 - sphingosine kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.01
(2R,3S,4E)-N-methyl-5-(4'-pentylphenyl)-2-aminopent-4-ene-1,3-diol
-
-
0.000125 - 0.0015
(2S)-1-(3-dodecylbenzoyl)pyrrolidine-2-carboximidamide
-
0.000047 - 0.0042
(2S)-1-(4-[4-[3-(2-cyclohexylethyl)phenyl]-1,3-oxazol-2-yl]benzoyl)pyrrolidine-2-carboximidamide
-
0.000075 - 0.003
(2S)-1-[3-[7-(cyclohexylmethoxy)heptyl]benzoyl]pyrrolidine-2-carboximidamide
-
0.00009 - 0.00012
(2S)-2-([3-[4-([4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino)phenyl]-1,2,4-oxadiazol-5-yl]methyl)pyrrolidine-1-carboximidamide
-
0.000089 - 0.0065
(2S)-2-[3-[3-(trifluoromethyl)-4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide
-
0.00037
(2S)-2-[3-[4-(octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide
isoform SphK2, at pH 8.0 and 25°C
-
0.00102 - 0.0038
(2S)-2-[3-[6-(hexyloxy)naphthalen-2-yl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide
-
0.00098
(2S)-2-[3-[6-(pentyloxy)naphthalen-2-yl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide
isoform SphK2, pH and temperature not specified in the publication
-
0.014 - 0.016
(2S,3R,4E)-2-(dimethylamino)octadec-4-ene-1,3-diol
0.00098
(2S,3S)-3-hydroxy-2-[3-[6-(2-methylpropoxy)naphthalen-2-yl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide
isoform SphK2, pH and temperature not specified in the publication
-
0.0009
(2S,3S)-3-hydroxy-2-[3-[6-(pentyloxy)naphthalen-2-yl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide
isoform SphK2, pH and temperature not specified in the publication
-
0.0064
(5Z)-3-(2-aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-1,3-thiazolidine-2,4-dione
-
0.044 - 0.093
(R)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
0.083 - 0.1
(R)-amino(2-((4-decylphenyl)carbamoyl)pyrrolidin-1-yl)-methaniminium 2,2,2-trifluoroacetate
0.088 - 0.096
(R)-amino(3-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)-pyrrolidin-1-yl)methaniminium
0.078 - 0.09
(S)-1-(1-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-guanidine
0.07 - 0.094
(S)-1-(2-methyl-1-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)-propyl)guanidine
0.000197
(S)-2-(3-(3-(tert-butyl)-4-((4-(trifluoromethyl)benzyl)-oxy)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
isoform SphK2, at pH 8.0 and 25°C
-
0.000089
(S)-2-(3-(3-(trifluoromethyl)-4-((4-(trifluoromethyl)-benzyl)oxy)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
isoform SphK2, at pH 8.0 and 25°C
-
0.000186
(S)-2-(3-(3-cyclopropyl-4-((4-(trifluoromethyl)-benzyl)oxy)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
isoform SphK2, at pH 8.0 and 25°C
-
0.000192
(S)-2-(3-(3-isopropyl-4-((4-(trifluoromethyl)benzyl)-oxy)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
isoform SphK2, at pH 8.0 and 25°C
-
0.000201
(S)-2-(3-(3-propyl-4-((4-(trifluoromethyl)benzyl)oxy)-phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
isoform SphK2, at pH 8.0 and 25°C
-
0.092 - 0.096
(S)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboximidamide
0.088 - 0.098
(S)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
0.042 - 0.096
(S)-2-(5-(4-octylphenyl)-1,3,4-oxadiazol-2-yl)pyrrolidin-1-ium 2,2,2-trifluoroacetate
0.085 - 0.094
(S)-amino((2-hydroxy-1-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)amino)methaniminium
0.012 - 0.075
(S)-amino(2-((3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)-methyl)pyrrolidin-1-yl)methaniminium chloride
0.091 - 0.1
(S)-amino(2-((4-decylphenyl)carbamoyl)pyrrolidin-1-yl)-methaniminium 2,2,2-trifluoroacetate
0.09 - 0.095
(S)-amino(2-((4-octylbenzamido)methyl)pyrrolidin-1-yl)-methaniminium 2,2,2-trifluoroacetate
0.095 - 0.1
(S)-amino(2-((4-octylbenzyl)carbamoyl)pyrrolidin-1-yl)-methaniminium 2,2,2-trifluoroacetate
0.077 - 0.08
(S)-amino(2-(2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)-ethyl)pyrrolidin-1-yl)methaniminium
0.1
(S)-amino(2-(2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)-ethyl)pyrrolidin-1-yl)methaniminium chloride
pH and temperature not specified in the publication
0.09 - 0.094
(S)-amino(2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)-2,5-di-hydro-1H-pyrrol-1-yl)methaniminium 2,2,2-trifluoroacetate
0.056 - 0.098
(S)-amino(2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)-piperidin-1-yl)methaniminium
0.091 - 0.095
(S)-amino(2-(5-(4-octylphenyl)-1,2,4-oxadiazol-3-yl)-pyrrolidin-1-yl)methaniminium
0.0145
(S)-FTY720 vinylphosphonate
pH 7.4, 30°C
0.075
1-((3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)methyl)guanidine
pH and temperature not specified in the publication
0.088 - 0.099
1-(1-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)cyclopropyl)-guanidine
0.0003 - 0.006
1-carbamimidoyl-N-(3-dodecylphenyl)cyclopropane-1-carboxamide
-
0.09 - 0.098
1-methyl-1-((3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)methyl)-guanidine
0.0001 - 0.0103
1-[3-(3-decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide
-
0.00004 - 0.0141
1-[3-(3-dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide
-
0.00098 - 0.0117
1-[3-(3-tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide
-
0.00007 - 0.0099
1-[3-(3-undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide
-
0.00044 - 0.006
1-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide
-
0.00032 - 0.008
1-[3-(4-dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide
-
0.0025 - 0.011
1-[3-(4-tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide
-
0.043 - 0.055
1-[3-(4-undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide
-
0.0004 - 0.0102
1-[5-(3-dodecylphenyl)-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboximidamide
-
0.0002 - 0.0081
1-[5-(3-dodecylphenyl)-1,3,4-oxadiazol-2-yl]cyclopropane-1-carboximidamide
-
0.003 - 0.0034
1-[5-(4-dodecylphenyl)-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboximidamide
-
0.0012 - 0.0016
1-[5-(4-dodecylphenyl)-1,3,4-oxadiazol-2-yl]cyclopropane-1-carboximidamide
-
0.0079 - 0.048
2-(4-hydroxyanilino)-4-(4-chlorophenyl)thiazole
0.0093
5-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)tricyclo[3.3.1.13,7]decane-2-carboxamide
pH not specified in the publication, temperature not specified in the publication
0.0031 - 0.0042
5-(4-chlorophenyl)-N-[2-(3,4-dihydroxyphenyl)ethyl]tricyclo[3.3.1.13,7]decane-2-carboxamide
0.00002
Amgen 82
isoform SphK2, pH and temperature not specified in the publication
-
0.069 - 0.092
amino((1S,3S)-3-hydroxy-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)methaniminium
0.07 - 0.096
amino((1S,4S)-4-hydroxy-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)methaniminium
0.065 - 0.098
amino((2S,4R)-4-hydroxy-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)methaniminium
0.084 - 0.09
amino(3-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)methaniminium
0.0022 - 0.004
B-5354c
0.0037
B5354c
-
0.005 - 0.018
D,L-threo-dihydrosphingosine
0.005
dimethylsphingosine
-
0.01
DL-threo-dihydrosphingosine
-
0.004 - 0.0055
F-12509A
0.002
FTY720
pH 7.4, 30°C
0.008 - 0.06
N,N-dimethyl-4-(3-octylphenyl)-N-propylcyclohexan-1-aminium
-
0.00033 - 0.012
N,N-dimethylsphingosine
0.0002 - 0.0005
N-(1-carbamimidoylcyclopropyl)-3-dodecylbenzamide
-
0.0046 - 0.0109
N-(1-carbamimidoylcyclopropyl)-4-dodecylbenzamide
-
0.00028
N-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-cyclohexylacetamide
pH not specified in the publication, temperature not specified in the publication
0.055
N-[(2S)-1-amino-1-iminopropan-2-yl]-3-octylbenzamide
isoform SphK1, pH and temperature not specified in the publication
-
0.0000043
PF-543
isoform SphK1, at pH 7.4 and 23°C
0.00037
SLM6031434
isoform SphK2, at pH 8.0 and 25°C
-
0.000089
SLM6071469
isoform SphK2, at pH 8.0 and 25°C
-
0.016
SLP-120701
IC50 above 100 mM, isoform SphK2, at pH 8.0 and 25°C
-
0.0014
SLR080811
isoform SphK2, pH and temperature not specified in the publication
0.02 - 0.055
VPC94075
-