2.7.1.90: diphosphate-fructose-6-phosphate 1-phosphotransferase
This is an abbreviated version!
For detailed information about diphosphate-fructose-6-phosphate 1-phosphotransferase, go to the full flat file.
Reaction
+
=
+
Synonyms
6-phosphofructokinase (pyrophosphate), AtPFPalpha2, diphosphate-D-fructose-6-phosphate 1-phosphotransferase, FBPase, fructose 1,6-bisphosphatase, inorganic pyrophosphate-dependent phosphofructokinase, inorganic pyrophosphate-phosphofructokinase, PFKA, PFP, PfpA4, phosphotransferase, pyrophosphate-D-fructose 6-phosphate 1-, PPi-dependent 6-phosphofructokinase, PPi-dependent phosphofructokinase, PPi-PFK, pyrophosphate D-fructose-6-phosphate 1-phosphotransferase, pyrophosphate-D-fructose 6-phosphate 1-phosphotransferase, pyrophosphate-D-fructose 6-phosphate phosphotransferase, pyrophosphate-dependent 6-phosphofructokinase, pyrophosphate-dependent fructose-6-phosphate 1-phosphotransferase, pyrophosphate-dependent phosphofructo-1-kinase, pyrophosphate-dependent phosphofructokinase, pyrophosphate-fructose-6-phosphate-phosphotransferase, pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase, pyrophosphate: fructose 6-phosphate 1-phosphotransferase, pyrophosphate: fructose-6-phosphate 1-phosphotransferase, pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase, pyrophosphate:fructose 6-phosphate 1-phosphotransferase, pyrophosphate:fructose-6-phosphate 1-phosphotransferase
ECTree
Metals Ions
Metals Ions on EC 2.7.1.90 - diphosphate-fructose-6-phosphate 1-phosphotransferase
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Ca2+
-
activates 120% at 0.1 mM
Fe2+
-
activates 120% at 0.1 mM
Na+
-
activates 135% at 10 mM
Co2+
-
less effective than Mg2+
Co2+
-
less effective than Mn2+
Co2+
-
inhibitory at high concentration
Co2+
-
less effective than Mg2+
Co2+
-
less effective than Mg2+
Co2+
-
less effective than Mn2+
Co2+
at 1 mM concentration Co2+ can replace Mg2+ (about 50% of Mg2+ activity)
Co2+
-
at low concentration (0.01 mM), Co2+ ions can replace Mg2+ (about 39% of the Mg2+ activity)
Co2+
-
less effective than Mg2+
Co2+
-
no activation of forward reaction
Co2+
-
no activation of forward reaction
divalent cations
-
required
divalent cations
-
descending order Mg2+, Mn2+ and Co2+
divalent cations
-
Mn2+ or Mg2+
divalent cations
-
required
divalent cations
-
descending order Mg2+, Mn2+ and Co2+
divalent cations
-
Mn2+ or Mg2+
divalent cations
-
activates 120% at 0.1 mM
divalent cations
-
required
divalent cations
-
desecending order Mn2+, Mg2+, Co2+
divalent cations
-
Mn2+ or Mg2+
divalent cations
-
required
divalent cations
-
Mn2+ or Mg2+
divalent cations
-
required
divalent cations
-
Mn2+ or Mg2+
divalent cations
-
required
divalent cations
-
desecending order Mn2+, Mg2+, Co2+
divalent cations
-
descending order Mg2+, Mn2+ and Co2+
divalent cations
-
required
divalent cations
-
Mn2+ or Mg2+
divalent cations
-
required
divalent cations
-
required
divalent cations
-
Mn2+ or Mg2+
K+
-
activates 140% at 10 mM
K+
-
slightly activating in forward reaction
Mg2+
-
requirement
Mg2+
-
optimal at 0.5-3.5 mM
Mg2+
-
less effective than Mn2+
Mg2+
-
enzyme requires 0.5 mM in the forward reaction, 0.0008 mM in the reverse reaction
Mg2+
-
substrates are Mg2+-chelated complexes of phosphate and diphosphate, respectively, not uncomplexed ligands
Mg2+
required, Km values of 0.03 mM (forward reaction) and 0.363 mM (reverse reaction) at pH 7.5 and 50°C
Mg2+
-
required for maximal activity, Co2+ or Mn2+ can substitute for Mg2+ with 63% and 48% of maximal activity
Mg2+
-
required, Km values of 0.047 mM (forward reaction) and 0.36 mM (reverse reaction) at pH 7.5 and 30°C
Mg2+
-
required for activity
Mg2+
-
magnesium diphosphate is the actual substrate of forward reaction
Mg2+
-
product inhibition of reverse reaction, kinetics
Mg2+
-
mainly required for the forward reaction
Mg2+
-
inhibitory at high concentration
Mg2+
-
less effective than Mn2+
Mg2+
-
inhibitory at high concentration
Mn2+
-
requirement
Mn2+
-
less effective than Mg2+
Mn2+
-
inhibitory at high concentration
Mn2+
-
less effective than Mg2+
Mn2+
at 1 mM concentration Mn2+ can replace Mg2+ (about 65% of Mg2+ activity)
Mn2+
-
at 1 mM concentration Mn2+ can replace Mg2+ (81% of Mg2+ activity)
Mn2+
-
at low concentration (0.01 mM), Mn2+ ions can replace Mg2+ (about 39% of the Mg2+ activity)
Mn2+
-
less effective than Mg2+
Mn2+
-
inhibitory in the forward reaction only, slightly activating in the reverse reaction
Mn2+
-
less effective than Mg2+
additional information
-
no activation by Zn2+
additional information
-
no activation by (NH4)2SO4
additional information
-
no activation by Ni2+
additional information
-
no activation by Zn2+
additional information
-
no activation by Cu2+
additional information
-
no activation by Zn2+
additional information
-
no activation by Fe2+
additional information
-
no activation by Zn2+
additional information
-
no activation by Cu2+
additional information
-
no activation by Ba2+, Sn2+, Sr2+