2.7.1.82: ethanolamine kinase
This is an abbreviated version!
For detailed information about ethanolamine kinase, go to the full flat file.
Word Map on EC 2.7.1.82
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2.7.1.82
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choline
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phosphatidylethanolamine
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phosphoethanolamine
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cdp-ethanolamine
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phosphocholine
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kennedy
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ptdetn
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cdp-choline
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setbp1
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medicine
- 2.7.1.82
- choline
- phosphatidylethanolamine
- phosphoethanolamine
- cdp-ethanolamine
- phosphocholine
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kennedy
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ptdetn
- cdp-choline
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setbp1
- medicine
Reaction
Synonyms
CEK4, choline/ethanolamine kinase, EKI, EKI1, ethanolamine kinase, ethanolamine kinase 1, ethanolamine kinase 2, ethanolamine phosphokinase, Etn kinase, EtnK, ETNK1, Etnk2, kinase, ethanolamine (phosphorylating), More, PfEK, Treki1
ECTree
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Inhibitors
Inhibitors on EC 2.7.1.82 - ethanolamine kinase
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3,3'-dodecane-1,12-diylbis[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium]
SAR97276
Inositol
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decreases gene EKI1 expression, involving the transcription factors Ino2p, Ino4p, and Opi1p, the UASINO element of the EKI promotor is required for the repressive regulation, the inhibitory effect on the enzyme is correlated with a decrease of ethanolamine incorporation into CDP-ethanolamine pathway intermediates and into phosphatidylethanolamine and phosphatidylcholine
SAR97276
bis-thiazolium compound designed as a choline analogue, affects ethanolamine kinase and choline kinase activities similarly. Inhibition is competitive and correlates with the impairment of cellular phosphatidylcholine biosynthesis
analogue of ethanolamine, selective inhibition
choline
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ethanolamine kinase I not inhibited, ethanolamine kinase II strongly inhibited
Mn2+
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presence of Mn2+ at lower concentrations of Mg2+ has an additive stimulating effect, at higher concentrations of Mg2+, Mn2+ inhibits
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not inhibitory: N-ethyl-N,N-dibutylethanolamine; not inhibitory: N-methyl-N-butylethanolamine; not inhibitory: N-methyl-N,N-diisopropylethanolamine; not inhibitory: N,N-diisopropylethanolamine; not inhibitory: N,N,N-triethanolamine; not inhibitory: serine
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additional information
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criterion for an effective inhibitor is the presence of only one N-alkyl group (except dimethylethanol) and a distance of 2 carbon atoms between the N atom and the OH group
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additional information
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enzyme expression is not affected by addition of choline
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