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2.7.1.82: ethanolamine kinase

This is an abbreviated version!
For detailed information about ethanolamine kinase, go to the full flat file.

Word Map on EC 2.7.1.82

Reaction

ATP
+
ethanolamine
=
ADP
+
O-Phosphoethanolamine

Synonyms

CEK4, choline/ethanolamine kinase, EKI, EKI1, ethanolamine kinase, ethanolamine kinase 1, ethanolamine kinase 2, ethanolamine phosphokinase, Etn kinase, EtnK, ETNK1, Etnk2, kinase, ethanolamine (phosphorylating), More, PfEK, Treki1

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.82 ethanolamine kinase

Inhibitors

Inhibitors on EC 2.7.1.82 - ethanolamine kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
2,3-Dimercaptopropanol
-
-
2-amino-1-butanol
3,3'-dodecane-1,12-diylbis[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium]
SAR97276
Acetyl-beta-methylcholine chloride
-
-
Acetylcholine
-
-
betaine
Butyrylcholine iodide
-
-
butyrylthiocholine iodide
-
-
choline
choline phosphate
-
-
cysteine
-
-
EGTA
-
stimulation at 0.4-0.9 mM, inhibition at 1.8 mM
Ethanolaminephosphate
-
-
hemicholinium
-
-
hemicholinium-3
-
Inositol
-
decreases gene EKI1 expression, involving the transcription factors Ino2p, Ino4p, and Opi1p, the UASINO element of the EKI promotor is required for the repressive regulation, the inhibitory effect on the enzyme is correlated with a decrease of ethanolamine incorporation into CDP-ethanolamine pathway intermediates and into phosphatidylethanolamine and phosphatidylcholine
Methane sulfonylcholine chloride
-
-
MgATP2-
-
substrate inhibition
monomethylethanolamine
-
-
N,N-dimethylethanolamine
N-ethylmaleimide
-
-
N-Methyl-N-isopropylethanolamine
-
-
N-Methylethanolamine
-
-
Ni2+
-
inhibits activating effect of Mg2+
p-chloromercuribenzoate
phosphorylcholine
Phosphorylethanolamine
Propionylcholine iodide
-
-
SAR97276
bis-thiazolium compound designed as a choline analogue, affects ethanolamine kinase and choline kinase activities similarly. Inhibition is competitive and correlates with the impairment of cellular phosphatidylcholine biosynthesis
stearoyl-CoA
-
-
Succinylcholine chloride
-
-
additional information
-