2.7.1.82: ethanolamine kinase
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For detailed information about ethanolamine kinase, go to the full flat file.
Word Map on EC 2.7.1.82
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2.7.1.82
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choline
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phosphatidylethanolamine
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phosphoethanolamine
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cdp-ethanolamine
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phosphocholine
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kennedy
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ptdetn
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cdp-choline
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setbp1
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medicine
- 2.7.1.82
- choline
- phosphatidylethanolamine
- phosphoethanolamine
- cdp-ethanolamine
- phosphocholine
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kennedy
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ptdetn
- cdp-choline
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setbp1
- medicine
Reaction
Synonyms
CEK4, choline/ethanolamine kinase, EKI, EKI1, ethanolamine kinase, ethanolamine kinase 1, ethanolamine kinase 2, ethanolamine phosphokinase, Etn kinase, EtnK, ETNK1, Etnk2, kinase, ethanolamine (phosphorylating), More, PfEK, Treki1
ECTree
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General Information
General Information on EC 2.7.1.82 - ethanolamine kinase
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evolution
malfunction
metabolism
physiological function
human ethanolamine kinase exists as three isoforms: EK1, EK2alpha and EK2beta, encoded by two separate genes; ek1, which produces the ek1 transcript variant 1, and ek2, which undergoes alternative splicing to produce ek2alpha (NCBI reference: NM_018208.2) and ek2beta (GenBank reference: AK001623.1) transcript variants. ek2alpha and ek2beta are respectively translated into EK2alpha and EK2beta
evolution
the enzmye belongs to the choline/ethanolamine kinase (CEK) family catalyzing the initial steps of phospholipid biosynthesis
knocking out of CEK4 caused an embryo-lethal phenotype with defective embryo development, which is complemented by transformation of genomic CEK4. Overexpression of enzyme CEK4 in wild-type Arabidopsis thaliana increases the levels of phosphatidylcholine in seedlings and mature siliques and of major membrane lipids in seedlings and triacylglycerol in mature siliques
malfunction
somatic enzyme mutations targeted to two contiguous amino acids in the ETNK1 kinase domain are involved in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia, phenotypes, overview
malfunction
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the gene Treki deletion mutant strain is less sensitive to cell wall stressors calcofluor white and Congo red and releases fewer protoplasts during cell wall digestion than the parent strain QM9414. The expression levels of five genes that encode chitin synthases are drastically increased in the Treki1 mutant, the chitin content is also increased in the null mutant of Treki1 comparing to the parent strain, and the Treki1 mutant exhibits defects in radial growth, conidiation and the accumulation of ethanolamine, phenotype overview
malfunction
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the gene Treki deletion mutant strain is less sensitive to cell wall stressors calcofluor white and Congo red and releases fewer protoplasts during cell wall digestion than the parent strain QM9414. The expression levels of five genes that encode chitin synthases are drastically increased in the Treki1 mutant, the chitin content is also increased in the null mutant of Treki1 comparing to the parent strain, and the Treki1 mutant exhibits defects in radial growth, conidiation and the accumulation of ethanolamine, phenotype overview
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metabolism
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catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway
metabolism
choline kinase and ethanolamine kinase are enzymes that initiate the first step in the Kennedy pathway, resulting in the biosynthesis of phosphatidylcholine and phosphatidylethanolamine. Expression profiling of ethanolamine kinase in MCF-7, HCT-116 and Hep-G2 cells, and the transcriptional regulation by epigenetic modification
metabolism
the enzyme catalyzes the initial steps of phospholipid biosynthesis
metabolism
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catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway
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enzyme CEK4 may be the plasma membrane-localized isoform of the CEK family involved in the rate-limiting step of phosphatidylcholine biosynthesis and appears to be required for embryo development in Arabidopsis thaliana
physiological function
splicing variant ek2beta exhibits a markedly low mRNA transcript level in all three of the cancer cell lines examined, thus suggesting that transcription of the ek2beta gene may be negligible and this isoform may not have a significant role in phosphatidyletanolamine synthesis in the three cancer cell lines
physiological function
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the enzyme plays a key role in growth and development and in the maintenance of cell wall integrity in Trichoderma reesei
physiological function
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the enzyme plays a key role in growth and development and in the maintenance of cell wall integrity in Trichoderma reesei
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