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2.7.1.81: hydroxylysine kinase

This is an abbreviated version!
For detailed information about hydroxylysine kinase, go to the full flat file.

Word Map on EC 2.7.1.81

Reaction

GTP
+
5-hydroxy-L-lysine
=
GDP
 +
5-phosphooxy-L-lysine

Synonyms

AGPHD1, guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase, hydroxylysine kinase (phosphorylating), kinase, hydroxylysine (phosphorylating)

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.81 hydroxylysine kinase

Substrates Products

Substrates Products on EC 2.7.1.81 - hydroxylysine kinase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 5-hydroxy-L-lysine
ADP + O-phosphohydroxy-L-lysine
show the reaction diagram
catalytic efficiency is 22fold higher with GTP than with ATP
-
-
?
GTP + 5-hydroxy-D-lysine
GDP + O-phosphohydroxy-D-lysine
show the reaction diagram
best substrate is the physiological form 5-hydroxy-L-lysine but human enzyme can also phosphorylate at a lower rate at least one other isomer
-
-
?
GTP + 5-hydroxy-L-lysine
GDP + O-phosphohydroxy-L-lysine
show the reaction diagram
GTP + allohydroxy-L-lysine
?
show the reaction diagram
-
-
-
-
?
additional information
?
-