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2.7.1.78: polynucleotide 5'-hydroxyl-kinase

This is an abbreviated version!
For detailed information about polynucleotide 5'-hydroxyl-kinase, go to the full flat file.

Word Map on EC 2.7.1.78

Reaction

ATP
+
5'-dephospho-DNA
=
ADP
 +
5'-phospho-DNA

Synonyms

5' end-specific RNA/DNA kinase, 5' polynucleotide kinase, 5'-hydroxyl polynucleotide kinase, 5'-hydroxyl polyribonucleotide kinase, 5'-hydroxyl RNA kinase, 5'-OH polynucleotide kinase, ATP:5'-dephosphopolynucleotide 5'-phosphatase, cleavage and polyadenylation factor I subunit, CLP1, Clp1-like protein, DNA 5'-hydroxyl kinase, DNA kinase, Grc3, HD-Pnk, HEAB, hPNKP, kinase (phosphorylating), polynucleotide 5'-hydroxyl, More, mPNKP, Nol9, PALF, PhoClp1, PNK, Pnk1, PNKP, polynucleotide 5'-hydroxyl kinase (phosphorylating), polynucleotide 5'-hydroxyl-kinase, polynucleotide kinase, polynucleotide kinase and aprataxin-like forkhead-associated, polynucleotide kinase phosphatase, polynucleotide kinase-phosphatase, polynucleotide kinase/phosphatase, RNA-specific polynucleotide kinase, Rnl1, RPNK, T4 PNK, T4 polynucleotide kinase, T4 polynucleotide kinase/phosphatase, tRNA endonuclease complex, TSEN

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.78 polynucleotide 5'-hydroxyl-kinase

Disease

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Disease on EC 2.7.1.78 - polynucleotide 5'-hydroxyl-kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review.
The "killer cell story" in recurrent miscarriage: Association between activated peripheral lymphocytes and uterine natural killer cells.
[IMMUNE DISORDERS AND THEIR ROLE IN ABORTION].
Abortion, Spontaneous
Concordance between peripheral and decidual NK cell subsets and killer immunoglobulin-like receptors in women with recurrent spontaneous miscarriages.
Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review.
Peripheral blood NK cells reflect changes in decidual NK cells in women with recurrent miscarriages.
Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence.
Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway.
Acquired Immunodeficiency Syndrome
Mutational analysis defines the 5'-kinase and 3'-phosphatase active sites of T4 polynucleotide kinase.
Adenocarcinoma
Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase.
Adenoma
Polynucleotide kinase 3' phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial.
Anemia
Vitamin B6 metabolism in anaemic and alcoholic man.
Anemia, Iron-Deficiency
Vitamin B6 metabolism in anaemic and alcoholic man.
Anemia, Sideroblastic
Vitamin B6 metabolism in anaemic and alcoholic man.
Apraxias
Compound Heterozygous Mutations in PNKP Gene in an Iranian Child with Microcephaly, Seizures, and Developmental Delay.
Breast Neoplasms
A potential role for peripheral natural killer cell activity induced by preoperative chemotherapy in breast cancer patients.
Carcinogenesis
Appearance of artefacts when using 32P-postlabelling to investigate DNA adduct formation by bile acids in vitro: lack of evidence for covalent binding.
Carcinoma
Development of a positive-negative selection procedure for gene targeting in fish cells.
Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase.
Carcinoma, Hepatocellular
Analysis of loss of nuclear RNA in azo dye-induced hepatoma by DNA-RNA competitive hybridization.
Diabetes, Gestational
Expression of Natural Cytotoxicity Receptors on and Intracellular Cytokine Production by NK Cells in Women with Gestational Diabetes Mellitus.
Immune System Diseases
The impact of previous live births on peripheral and uterine natural killer cells in patients with recurrent miscarriage.
Infections
Bacteriophage T4 polynucleotide kinase triggers degradation of mRNAs.
Bacteriophage T4-induced anticodon-loop nuclease detected in a host strain restrictive to RNA ligase mutants.
Host transfer RNA cleavage and reunion in T4-infected Escherichia coli CTr5x.
In vitro reconstitution of anticodon nuclease from components encoded by phage T4 and Escherichia coli CTr5X.
Phage and host genetic determinants of the specific anticodon loop cleavages in bacteriophage T4-infected Escherichia coli CTr5X.
[Biosynthesis of early enzymes induced by bacteriophage T4]
Infertility
Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review.
Intellectual Disability
Compound Heterozygous Mutations in PNKP Gene in an Iranian Child with Microcephaly, Seizures, and Developmental Delay.
Leukemia
Single prokaryotic cell isolation and total transcript amplification protocol for transcriptomic analysis.
Leukemia, Myeloid, Acute
CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy.
Lymphatic Metastasis
A potential role for peripheral natural killer cell activity induced by preoperative chemotherapy in breast cancer patients.
Immune correlates of the differing pathological and therapeutic effects of neoadjuvant chemotherapy in breast cancer.
Lymphoma
Maternal-iron-deficiency effects on peritoneal macrophage and peritoneal natural-killer-cell cytotoxicity in rat pups.
Microcephaly
A Novel c.968C?>?T homozygous Mutation in the Polynucleotide Kinase 3'?-?Phosphatase Gene Related to the Syndrome of Microcephaly, Seizures, and Developmental Delay.
Compound Heterozygous Mutations in PNKP Gene in an Iranian Child with Microcephaly, Seizures, and Developmental Delay.
Microcephalic primordial dwarfism in an Emirati patient with PNKP mutation.
Microphthalmos
Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence.
Neoplasm Metastasis
A potential role for peripheral natural killer cell activity induced by preoperative chemotherapy in breast cancer patients.
Immune correlates of the differing pathological and therapeutic effects of neoadjuvant chemotherapy in breast cancer.
Immune factors associated with the pathological and therapeutic effects of preoperative chemotherapy in patients with breast cancer.
Neoplasms
A label-free bioluminescent sensor for real-time monitoring polynucleotide kinase activity.
A potential role for peripheral natural killer cell activity induced by preoperative chemotherapy in breast cancer patients.
CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy.
Characterization and ex vivo Expansion of Human Placenta-Derived Natural Killer Cells for Cancer Immunotherapy.
DNA end-processing enzyme polynucleotide kinase as a potential target in the treatment of cancer.
Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase.
Immune correlates of the differing pathological and therapeutic effects of neoadjuvant chemotherapy in breast cancer.
Immune factors associated with the pathological and therapeutic effects of preoperative chemotherapy in patients with breast cancer.
Maternal-iron-deficiency effects on peritoneal macrophage and peritoneal natural-killer-cell cytotoxicity in rat pups.
Mimic Peroxidase- and Bi2S3 Nanorod-Based Photoelectrochemical Biosensor for Signal-On Detection of Polynucleotide Kinase.
Problem-solving test: analysis of DNA damage recognizing proteins in yeast and human cells.
Renal cell tumors convert natural killer cells to a proangiogenic phenotype.
Single-Molecule Detection of Polynucleotide Kinase Based on Phosphorylation-Directed Recovery of Fluorescence Quenched by Au Nanoparticles.
Neurodegenerative Diseases
2 new cases of pontocerebellar hypoplasia type 10 identified by whole exome sequencing in a Turkish family.
Pelvic Inflammatory Disease
A novel fluorescence method for activity assay and drug screening of T4 PNK by coupling rGO with ligase reaction.
Polyneuropathies
Genetic assessment and folate receptor autoantibodies in infantile-onset cerebral folate deficiency (CFD) syndrome.
Pregnancy Complications
[ACTIVATION OF PERIPHERAL NATURAL KILLER CELLS IN WOMEN WITH REPEATED EARLY PREGNANCY LOSS].
Respiratory Insufficiency
Prepacked naloxone administration for suspected opioid overdose in the era of illicitly manufactured fentanyl: a retrospective study of regional poison center data.
Seizures
A Novel c.968C?>?T homozygous Mutation in the Polynucleotide Kinase 3'?-?Phosphatase Gene Related to the Syndrome of Microcephaly, Seizures, and Developmental Delay.
Compound Heterozygous Mutations in PNKP Gene in an Iranian Child with Microcephaly, Seizures, and Developmental Delay.
Microcephalic primordial dwarfism in an Emirati patient with PNKP mutation.
Vaccinia
A nuclease that cuts specifically in the ribosome binding site of some T4 mRNAs.