2.7.1.74: deoxycytidine kinase
This is an abbreviated version!
For detailed information about deoxycytidine kinase, go to the full flat file.
Word Map on EC 2.7.1.74
-
2.7.1.74
-
leukemia
-
gemcitabine
-
thymidine
-
triphosphate
-
deaminase
-
purine
-
ribonucleotide
-
deoxynucleoside
-
pyrimidine
-
deoxyguanosine
-
salvage
-
myeloid
-
arabinoside
-
cytarabine
-
prodrugs
-
deoxyadenosine
-
1-beta-d-arabinofuranosylcytosine
-
deoxyribonucleoside
-
5'-nucleotidase
-
cladribine
-
cross-resistance
-
ara-ctp
-
2-chlorodeoxyadenosine
-
2',2'-difluorodeoxycytidine
-
fludarabine
-
dttp
-
antileukemic
-
ccrf-cem
-
dfdctp
-
2-chloro-2'-deoxyadenosine
-
gemcitabine-resistant
-
dado
-
deoxycytidylate
-
kinase-deficient
-
clofarabine
-
2',3'-dideoxycytidine
-
5'-phosphorylation
-
arabinosyl
-
deoxypyrimidine
-
t-lymphoblastoid
-
deoxycoformycin
-
medicine
-
2'-deoxyadenosine
-
deoxythymidine
-
l-nucleoside
-
dideoxycytidine
-
t-lymphoblasts
-
2',3'-dideoxyinosine
-
tetrahydrouridine
-
arabinosylcytosine
-
anabolites
-
pharmacology
-
analysis
- 2.7.1.74
- leukemia
- gemcitabine
- thymidine
- triphosphate
- deaminase
- purine
- ribonucleotide
- deoxynucleoside
- pyrimidine
- deoxyguanosine
-
salvage
- myeloid
- arabinoside
- cytarabine
-
prodrugs
- deoxyadenosine
- 1-beta-d-arabinofuranosylcytosine
- deoxyribonucleoside
- 5'-nucleotidase
- cladribine
-
cross-resistance
- ara-ctp
- 2-chlorodeoxyadenosine
- 2',2'-difluorodeoxycytidine
- fludarabine
- dttp
-
antileukemic
-
ccrf-cem
-
dfdctp
- 2-chloro-2'-deoxyadenosine
-
gemcitabine-resistant
-
dado
- deoxycytidylate
-
kinase-deficient
- clofarabine
- 2',3'-dideoxycytidine
-
5'-phosphorylation
-
arabinosyl
-
deoxypyrimidine
-
t-lymphoblastoid
- deoxycoformycin
- medicine
- 2'-deoxyadenosine
- deoxythymidine
-
l-nucleoside
- dideoxycytidine
- t-lymphoblasts
- 2',3'-dideoxyinosine
- tetrahydrouridine
- arabinosylcytosine
-
anabolites
- pharmacology
- analysis
Reaction
Synonyms
2'-deoxycytidine kinase, ara-C kinase, arabinofuranosylcytosine kinase, dC kinase, dCK, deoxycytidine kinase, deoxycytidine-cytidine kinase, dNTP:deoxycytidine 5'-phosphotransferase, kinase, deoxycytidine (phosphorylating), NTP:deoxycytidine 5'-phosphotransferase
ECTree
2.7.1.74 deoxycytidine kinaseAdvanced search results
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Natural Substrates Products on EC 2.7.1.74 - deoxycytidine kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 2',2'-difluorodeoxycytidine
ADP + 2',2'-difluorodeoxycytidine monophosphate
-
i.e. gemcitabine, transport and metabolism in vivo, overview
-
-
?
ATP + 2-chlorodeoxyadenosine
ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
i.e. cladribine
-
-
?
ATP + cytarabine
ADP + cytarabine 5'-phosphate
-
drug against acute myeloid and lymphoblastic leukemia
-
-
?
ATP + L-thymidine
?
human dCK, in addition to being able to phosphorylate both purines and pyrimidines, has the special ability to accept L-nucleosides as substrates
-
-
?
NTP + (-)-beta-2',3'-dideoxy-3'-thiacytidine
NDP + (-)-beta-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
activation of the clinically relevant substrate
-
-
?
NTP + 1-beta-D-arabinofuranosylcytosine
NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
NTP + 1-beta-D-arabinosylcytosine
NDP + 1-beta-D-arabinosylcytosine 5'-phosphate
i.e. cytaribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
-
-
?
NTP + 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
NDP + 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine 5'-phosphate
i.e. clofarabine, rate-limiting step in the activation of the prodrug, precursor of an effective chemotherapeutic agent for leukemias and other haematological malignancies
-
-
?
NTP + 9-beta-D-arabinosyl 2-fluoroadenine
NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
NTP + 9-beta-D-arabinosyl-2-fluoroadenine
NDP + 9-beta-D-arabinosyl-2-fluoroadenine 5'-phosphate
-
phosphorylation of chemotherapeutically important nucleoside analogues
-
-
?
NTP + troxacitabine
?
activation of the clinically relevant substrate
-
-
?
UTP + 2',3'-dideoxycytidine
UDP + 2',3'-dideoxycytidine 5'-phosphate
-
i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
-
-
?
UTP + 2'-deoxy-3'-thiacytidine
UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
rate-limiting reaction in the salvage of deoxyribonucleosides
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
involved in nucleotide synthesis, involved in DNA repair
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
rate-limiting reaction in the salvage of deoxyribonucleosides
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
-
-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
rate-limiting reaction in the salvage of deoxyribonucleosides
-
-
?
ATP + deoxycytidine
ADP + ?
-
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
-
-
?
ATP + deoxycytidine
ADP + ?
-
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
-
-
?
ATP + deoxycytidine
ADP + ?
-
key anabolic enzyme for activation of purine or pyrimidine deoxynucleosides as well as cytidine arabinoside and other anti-tumor drugs
-
-
?
ATP + deoxycytidine
ADP + ?
-
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
-
-
?
NTP + 1-beta-D-arabinofuranosylcytosine
NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
antineoplastic agent
-
-
?
NTP + 1-beta-D-arabinofuranosylcytosine
NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
i.e. cytarabine, rate limiting enzyme in the activation of the prodrug
-
-
?
NTP + 2',2'-difluorodeoxycytidine
NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
i.e. gemcitabine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of solid malignant tumors
-
-
?
NTP + 2',2'-difluorodeoxycytidine
NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of solid malignant tumors
-
-
?
NTP + 2',2'-difluorodeoxycytidine
NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of tumors
-
-
?
NTP + 2',2'-difluorodeoxycytidine
NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
substrate also termed gemcitabine
-
-
?
NTP + 2',3'-dideoxycytidine
NDP + 2',3'-dideoxycytidine 5'-phosphate
antiviral agent
-
-
?
NTP + 2',3'-dideoxycytidine
NDP + 2',3'-dideoxycytidine 5'-phosphate
i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used in the treatment of HIV infections
-
-
?
NTP + 2'-deoxy-3'-thiacytidine
NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
antiviral agent
-
-
?
NTP + 2'-deoxy-3'-thiacytidine
NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used in the treatment of HIV infections
-
-
?
NTP + 2'-deoxyadenosine
NDP + 2'-deoxyadenosine 5'-phosphate
rate-limiting reaction in the salvage of deoxyribonucleosides
-
-
?
NTP + 2'-deoxycytidine
NDP + 2'-deoxycytidine 5'-phosphate
more effective substrate than 2'-deoxyadenosine and 2'-deoxyguanosine
-
-
?
NTP + 2'-deoxycytidine
NDP + 2'-deoxycytidine 5'-phosphate
rate-limiting reaction in the salvage of deoxyribonucleosides
-
-
?
NTP + 2'-deoxyguanosine
NDP + 2'-deoxyguanosine 5'-phosphate
rate-limiting reaction in the salvage of deoxyribonucleosides
-
-
?
NTP + 2-chloro-2'-deoxyadenosine
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
-
-
?
NTP + 2-chloro-2'-deoxyadenosine
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
-
-
?
NTP + 2-chloro-2'-deoxyadenosine
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
i.e. cladribine, antineoplastic agent
-
-
?
NTP + 2-chloro-2'-deoxyadenosine
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
phosphorylation of chemotherapeutically important nucleoside analogues
-
-
?
NTP + 9-beta-D-arabinosyl 2-fluoroadenine
NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
-
activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
-
-
?
NTP + 9-beta-D-arabinosyl 2-fluoroadenine
NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
i.e. fludarabine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
-
-
?
UTP + 2'-deoxyadenosine
UDP + 2'-deoxyadenosine 5'-phosphate
rate-limiting reaction in the salvage of deoxyribonucleosides
-
-
?
UTP + 2'-deoxyadenosine
UDP + 2'-deoxyadenosine 5'-phosphate
-
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
-
-
?
UTP + 2'-deoxycytidine
UDP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
UTP + 2'-deoxycytidine
UDP + 2'-deoxycytidine 5'-phosphate
-
preferred donor and acceptor substrates
-
-
?
UTP + 2'-deoxycytidine
UDP + 2'-deoxycytidine 5'-phosphate
rate-limiting reaction in the salvage of deoxyribonucleosides
-
-
?
UTP + 2'-deoxycytidine
UDP + 2'-deoxycytidine 5'-phosphate
-
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
-
-
?
UTP + 2'-deoxyguanosine
UDP + 2'-deoxyguanosine 5'-phosphate
rate-limiting reaction in the salvage of deoxyribonucleosides
-
-
?
additional information
?
-
-
5'-phosphorylation of is a crucial step in metabolic activation of anticancer and antiviral nucleoside antimetabolites, such as cladribine, gemcitabine, cytarabine, and lamivudine
-
-
?
additional information
?
-
de novo synthesis and salvage of ribonucleotides and deoxyribonucleotides, metabolism overview, enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview
-
-
?
additional information
?
-
-
enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview
-
-
?
additional information
?
-
-
resistance of cells to cytarabine is caused by dCK enzyme deficiency
-
-
?
additional information
?
-
-
the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity
-
-
?
additional information
?
-
the earliest nucleotide kinase in evolution, probably encoded by the so-called dCK/dGK/TK2-like gene, is the progenitor gene, several duplications of it are the reason for evolutionary occurrence of nucleoside kinases with strict substrate specificities in other organism, phylogenetic tree, overview
-
-
?
additional information
?
-
-
the enzyme is active and important in activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies
-
-
?
additional information
?
-
catalyzes the rate-limiting step of the deoxyribonucleoside salvage pathway, key role in the activation of numerous nucleoside analogues used in anti-cancer and antiviral chemotherapy
-
-
?
additional information
?
-
-
catalyzes the rate-limiting step of the deoxyribonucleoside salvage pathway, key role in the activation of numerous nucleoside analogues used in anti-cancer and antiviral chemotherapy
-
-
?
additional information
?
-
-
dCK is able to phosphorylate both D- and L-nucleosides and nucleoside analogs
-
-
?
additional information
?
-
dCK is able to phosphorylate both D- and L-nucleosides and nucleoside analogs
-
-
?
additional information
?
-
-
enzyme of the salvage pathway for deoxyribonucleotide synthesis, which provides resting cells with deoxynucleotides for DNA repair and mitochondrial DNA synthesis, important enzyme for the phosphorylation/activation of deoxynucleoside analogues, which are cytotoxic towards both replicating and indolent malignancies
-
-
?
additional information
?
-
-
essential for the synthesis of deoxynucleotides required for DNA repair and involved in deoxynucleoside analogue activation
-
-
?
additional information
?
-
-
key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy
-
-
?
additional information
?
-
phosphorylates both pyrimidine and purine deoxynucleosides, including numerous nucleoside analogue anticancer and antiviral prodrugs
-
-
?
additional information
?
-
-
phosphorylates both pyrimidine and purine deoxynucleosides, including numerous nucleoside analogue anticancer and antiviral prodrugs
-
-
?
additional information
?
-
-
dCK phosphorylates all three natural deoxyribonucleosides, exhibiting the highest affinity for 2'-deoxycytidine
-
-
?
additional information
?
-
-
dCK interacts with cyclin-dependent kinase 1 (Cdk1) and the interaction inhibits Cdk1 activity both in vitro and in vivo
-
-
?
additional information
?
-
-
development and evaluation of a homogeneous fluorescence-based assay for real-time and simultaneous detection of thymidine kinase 1 and deoxycytidine kinase activities, detailed overview
-
-
?
additional information
?
-
the earliest nucleotide kinase in evolution, probably encoded by the so-called dCK/dGK/TK2-like gene, is the progenitor gene, several duplications of it are the reason for evolutionary occurrence of nucleoside kinases with strict substrate specificities in other organism, phylogenetic tree, overview
-
-
?
