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2.7.1.74: deoxycytidine kinase

This is an abbreviated version!
For detailed information about deoxycytidine kinase, go to the full flat file.

Word Map on EC 2.7.1.74

Reaction

NTP
+
deoxycytidine
=
NDP
 +
dCMP

Synonyms

2'-deoxycytidine kinase, ara-C kinase, arabinofuranosylcytosine kinase, dC kinase, dCK, deoxycytidine kinase, deoxycytidine-cytidine kinase, dNTP:deoxycytidine 5'-phosphotransferase, kinase, deoxycytidine (phosphorylating), NTP:deoxycytidine 5'-phosphotransferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.74 deoxycytidine kinase

KI Value

KI Value on EC 2.7.1.74 - deoxycytidine kinase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000008
1-(5-(4-(((4,6-diaminopyrimidin-2-yl)thio)methyl)-5-propylthiazol-2-yl)-2-methoxyphenoxy)-2-methylpropan-2-ol
at pH 7.6 and 37°C
0.3
2'-O-methylcytidine
-
37°C, pH 7.6
0.0000095
2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine
at pH 7.6 and 37°C
0.0000015
2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-propylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine
at pH 7.6 and 37°C
0.02
3'-O-methyl-2'deoxycytidine
-
37°C, pH 7.6
0.032
5'-O-ethyl-2'-deoxycytidine
-
37°C, pH 7.6
0.23
5'-O-methyl-2'-deoxycytidine
-
37°C, pH 7.6
0.0015 - 0.022
dCMP
0.0015 - 0.398
dCTP
0.0000005
N-(2-(5-(4-(((4,6-diaminopyrimidin-2-yl)thio)methyl)-5-propylthiazol-2-yl)-2-methoxyphenoxy)ethyl)methanesulfonamide
at pH 7.6 and 37°C
0.0004 - 0.0069
UDP
additional information
additional information
-
steady-state fluorescent measurement, inhibitor binding constant, recombinant enzyme
-