2.7.1.74: deoxycytidine kinase
This is an abbreviated version!
For detailed information about deoxycytidine kinase, go to the full flat file.
Word Map on EC 2.7.1.74
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2.7.1.74
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leukemia
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gemcitabine
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thymidine
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triphosphate
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deaminase
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purine
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ribonucleotide
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deoxynucleoside
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pyrimidine
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deoxyguanosine
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salvage
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myeloid
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arabinoside
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cytarabine
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prodrugs
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deoxyadenosine
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1-beta-d-arabinofuranosylcytosine
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deoxyribonucleoside
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5'-nucleotidase
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cladribine
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cross-resistance
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ara-ctp
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2-chlorodeoxyadenosine
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2',2'-difluorodeoxycytidine
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fludarabine
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dttp
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antileukemic
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ccrf-cem
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dfdctp
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2-chloro-2'-deoxyadenosine
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gemcitabine-resistant
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dado
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deoxycytidylate
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kinase-deficient
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clofarabine
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2',3'-dideoxycytidine
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5'-phosphorylation
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arabinosyl
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deoxypyrimidine
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t-lymphoblastoid
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deoxycoformycin
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medicine
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2'-deoxyadenosine
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deoxythymidine
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l-nucleoside
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dideoxycytidine
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t-lymphoblasts
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2',3'-dideoxyinosine
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tetrahydrouridine
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arabinosylcytosine
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anabolites
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pharmacology
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analysis
- 2.7.1.74
- leukemia
- gemcitabine
- thymidine
- triphosphate
- deaminase
- purine
- ribonucleotide
- deoxynucleoside
- pyrimidine
- deoxyguanosine
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salvage
- myeloid
- arabinoside
- cytarabine
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prodrugs
- deoxyadenosine
- 1-beta-d-arabinofuranosylcytosine
- deoxyribonucleoside
- 5'-nucleotidase
- cladribine
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cross-resistance
- ara-ctp
- 2-chlorodeoxyadenosine
- 2',2'-difluorodeoxycytidine
- fludarabine
- dttp
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antileukemic
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ccrf-cem
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dfdctp
- 2-chloro-2'-deoxyadenosine
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gemcitabine-resistant
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dado
- deoxycytidylate
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kinase-deficient
- clofarabine
- 2',3'-dideoxycytidine
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5'-phosphorylation
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arabinosyl
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deoxypyrimidine
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t-lymphoblastoid
- deoxycoformycin
- medicine
- 2'-deoxyadenosine
- deoxythymidine
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l-nucleoside
- dideoxycytidine
- t-lymphoblasts
- 2',3'-dideoxyinosine
- tetrahydrouridine
- arabinosylcytosine
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anabolites
- pharmacology
- analysis
Reaction
Synonyms
2'-deoxycytidine kinase, ara-C kinase, arabinofuranosylcytosine kinase, dC kinase, dCK, deoxycytidine kinase, deoxycytidine-cytidine kinase, dNTP:deoxycytidine 5'-phosphotransferase, kinase, deoxycytidine (phosphorylating), NTP:deoxycytidine 5'-phosphotransferase
ECTree
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General Information
General Information on EC 2.7.1.74 - deoxycytidine kinase
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malfunction
metabolism
physiological function
additional information
malfunction
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dCK inactivation selectively and profoundly affects T and B cell development, severe impact of dCK inactivation on lymphopoiesis. Inactivation of dCK induces a partial block in B cell development
malfunction
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deoxxycytidine kinase inhibition causes gemcitabine resistance, overview
malfunction
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inhibition of the enzyme results in diminished dAdomediated apoptosis in the lungs
malfunction
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inhibition of the enzyme results in diminished deoxyadenosine-mediated apoptosis in the lungs
malfunction
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mechanisms of cell killing by activated bromovinyl-deoxyuridine in Jurkat cells expressing thymidine-activating deoxycytidine kinase, cell fate control gene therapy strategy, overview. Tumor formation is repressed by dCK-based cell fate control gene therapy strategy in vivo in a xenogeneic murine model and thymidine-activating dCK mutant increased survival in a stringent model of T cell leukemia
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dCK plays an important role in the salvage pathway of nucleoside metabolism
metabolism
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2',2'-difluorodeoxycytidine, i.e. gemcitabine, is phosphorylated intracellularly via multiple steps, and the triphosphate inhibits DNA synthesis by interfering with incorporation of endogenous dCTP into DNA, deocycytidine kinase catalyzes the first phosphorylation step, overview
metabolism
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dCK function in the context of cytosolic deoxycytidine metabolism, model, overview
metabolism
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deoxycytidine kinase is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway
metabolism
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deoxycytidine kinase is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway
metabolism
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deoxycytidine kinase is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway
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cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview
physiological function
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cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview
physiological function
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deoxycitidine kinase is a major enzyme for deoxyadenosine phosphorylation. Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease, hypoxia is a regulator of the enzyme
physiological function
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deoxycitidine kinase is a major enzyme for deoxyadenosine phosphorylation. Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease, hypoxia is a regulator of the enzyme. Activating the dAdo-DCK-dATP pathway directly results in increased apoptosis in the lungs of mice with air-space enlargement, the dAdo-DCK pathway is activated in the lungs of Ada-/- mice, overview
physiological function
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deoxycytidine kinase (dCK) is a rate limiting enzyme critical for phosphorylation of endogenous deoxynucleosides for DNA synthesis and exogenous nucleoside analogues for anticancer and antiviral drug actions. The enzyme is activated in response to DNA damage. Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damagereqquiring its phosphorylation at Ser74, overview
physiological function
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deoxycytidine kinase is a key enzyme in the salvage of deoxyribonucleosides and in the activation of several anticancer and antiviral nucleoside analogues
physiological function
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deoxycytidine kinase is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that recycles products of DNA degradation. The enzyme phosphorylates and therefore activates nucleoside analogue prodrugs frequently used in cancer, autoimmunity, and viral infections. Normal lymphocyte development critically requires the deoxyribonucleoside salvage pathway
physiological function
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deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity in Saos-2 cells and OCI-AML3 cells, ABCG2 primarily effluxes clofarabine, but not chlorfarabine-monophosphate, overview
physiological function
phosphorylation of Ser74 might be a mechanism for regulating the specificity of the kinase to favor deoxycytidine
physiological function
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deoxycytidine kinase promotes the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients
physiological function
the enzyme confers resistance against cytarabine in acute myeloid leukaemia
physiological function
the phosphorylated and activated enzyme can inhibit ionizing radiation-induced cell death including apoptosis and mitotic catastrophe, and promote ionizing radiation-induced autophagy through PI3K/Akt/mTOR pathway. The enzyme is required for the G2/M cell cycle checkpoint and to protect cells against mitotic catastrophe
physiological function
the phosphorylated and activated enzyme inhibits IR-induced total cell death and apoptosis, and promotes ionizing radiation-induced autophagy through the phospho-mammalian target of rapamycin pathway and by inhibiting the binding of Bcl-2 protein to Bcl-2/Beclin1
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biodistribution of cytosine derivative substrates in mouse healthy and malignant tissues, overview
additional information
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deoxycytidine kinase is a key enzyme in the activation of several therapeutic nucleoside analogues
additional information
structure-function analysis and substrate specificity, overview
additional information
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structure-function analysis and substrate specificity, overview
additional information
structure-function analysis, comparison of wild-type enzyme and mutant S74E
additional information
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structure-function analysis, comparison of wild-type enzyme and mutant S74E
additional information
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biodistribution of cytosine derivative substrates in mouse healthy and malignant tissues, overview
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