2.7.1.71: shikimate kinase
This is an abbreviated version!
For detailed information about shikimate kinase, go to the full flat file.
Word Map on EC 2.7.1.71
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2.7.1.71
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chorismate
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shikimate-3-phosphate
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chrysanthemi
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oseltamivir
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dahp
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5-enolpyruvylshikimate
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3-deoxy-d-arabino-heptulosonate
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dehydroquinate
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7-phosphate
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drug development
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synthesis
- 2.7.1.71
- chorismate
-
shikimate-3-phosphate
- chrysanthemi
- oseltamivir
- dahp
-
5-enolpyruvylshikimate
-
3-deoxy-d-arabino-heptulosonate
- dehydroquinate
- 7-phosphate
- drug development
- synthesis
Reaction
Synonyms
adenosine triphosphate: shikimate-3-phosphotransferase, AroK, AroL, AtSK1, AtSK2, kinase (phosphorylating), shikimate, kinase, shikimate (phosphorylating), MtSK, OsSK1, OsSK2, OsSK3, Rv2539c, shikimate kinase II, shikimate kinase-like 1, SK I, SK II, SK1, SK2, SKI, SKII, SKL1, type I shikimate kinase, aroK-encoded, type II shikimate kinase
ECTree
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Temperature Stability
Temperature Stability on EC 2.7.1.71 - shikimate kinase
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37
isozyme AtSK2 is highly unstable and becomes inactivated at 37°C, whereas the heat-induced isoform, AtSK1, is thermostable and fully active at 37°C
4 - 26
after 8 h of incubation, the enzyme maintains its maximal activity in a range from 4 to 20°C, while at 25 and 26°C, it drops to 70% and 60%, respectively. A further increase of two degrees leads to the loss of 70% of the maximal activity, and at 30°C the enzyme is practically inactive
40
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midpoint of protein unfolding transition is 39.7°C for the wild-type enzyme, 39°C for the mutant enzyme C13S and 43.0°C for the wild-type enzyme K15M in absence of ligands