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2.7.1.71: shikimate kinase

This is an abbreviated version!
For detailed information about shikimate kinase, go to the full flat file.

Word Map on EC 2.7.1.71

Reaction

ATP
+
shikimate
=
ADP
 +
3-phosphoshikimate

Synonyms

adenosine triphosphate: shikimate-3-phosphotransferase, AroK, AroL, AtSK1, AtSK2, kinase (phosphorylating), shikimate, kinase, shikimate (phosphorylating), MtSK, OsSK1, OsSK2, OsSK3, Rv2539c, shikimate kinase II, shikimate kinase-like 1, SK I, SK II, SK1, SK2, SKI, SKII, SKL1, type I shikimate kinase, aroK-encoded, type II shikimate kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.71 shikimate kinase

KI Value

KI Value on EC 2.7.1.71 - shikimate kinase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.645
(1R,4R,6S,10S)-6,10-dihydroxy-4-methyl-2-oxabicyclo[4.3.1]dec-7-ene-8-carboxylic acid
at pH 7.7 and 25°C
0.36 - 0.465
(1R,4S,6S,10S)-6,10-dihydroxy-4-methyl-2-oxabicyclo[4.3.1]dec-7-ene-8-carboxylic acid
0.068 - 0.121
(1R,6S,10S)-4-benzyloxymethyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
0.012 - 0.177
(1R,6S,10S)-4-butyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
0.01 - 0.101
(1R,6S,10S)-4-cyclopropylmethyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
0.005 - 0.17
(1R,6S,10S)-4-ethoxymethyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
0.0155 - 0.041
(1R,6S,10S)-4-ethyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
0.038 - 0.333
(1R,6S,10S)-4-hydroxylmethyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
0.046 - 0.047
(1R,6S,10S)-6,10-dihydroxy-2-oxabicyclo[4.3.1]dec-7-ene-8-carboxylic acid
0.062 - 0.104
(1R,6S,10S)-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4,7-diene-8-carboxylic acid
0.028 - 0.0545
(1R,6S,10S)-6,10-dihydroxy-4-methyl-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
0.0092 - 0.072
(1R,6S,10S)-6,10-dihydroxy-4-propyl-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
1.05
(3aR,6R,7R,7aS)-6,7-dihydroxy-2,2-dimethyl-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylic acid
-
pH and temperature not specified in the publication
0.001 - 0.135
(3R,4R,5R)-3,4-dihydroxy-5-(3-methoxybenzyloxy)cyclohex-1-ene-1-carboxylic acid
0.0021 - 0.109
(3R,4R,5R)-3,4-dihydroxy-5-(3-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid
0.0109 - 0.166
(3R,4R,5R)-3,4-dihydroxy-5-(4-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid
0.0018 - 0.022
(3R,4R,5R)-3,4-dihydroxy-5-(naphthalen-2-ylmethoxy)cyclohex-1-ene-1-carboxylic acid
0.0018 - 0.022
(3R,4R,5R)-3,4-dihydroxy-5-(naphthyl-2-yl)methoxycyclohex-1-ene-1-carboxylic acid
0.062
(3R,4R,5R)-3-amino-4,5-dihydroxycyclohex-1-ene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.00056 - 0.043
(3R,4R,5R)-5-(1-benzothiophen-5-ylmethoxy)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid
0.00128 - 0.18
(3R,4R,5R)-5-(3-fluorobenzyloxy)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid
0.00056 - 0.043
(3R,4R,5R)-5-(benzo[b]thiophen-5-yl)methoxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid
0.003 - 0.036
(3R,4R,5R)-5-benzyloxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid
0.792
(3R,4R,5R,6R)-3,4,5,6-tetrahydroxycyclohex-1-ene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.095 - 2
(3R,4S,5R)-5-(4-benzyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid
0.067 - 2
(3R,4S,5R)-5-(4-phenoxymethyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid
0.0082 - 0.0087
(3R,4S,5R)-5-bis(3-bromo-1H-indol-5-yl)methylamino-3,4-dihydroxycyclohex-1-eno-1-carboxylic acid
0.065
(3S,4R,5R)-3-amino-4,5-dihydroxycyclohex-1-ene-1-carboxylic acid
-
pH and temperature not specified in the publication
0.0055
3-methoxy-4-[2-[2-([2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl)phenyl]ethyl]benzaldehyde
-
pH and temperature not specified in the publication
0.00948
3-methoxy-4-[[2-([2-methoxy-4-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl)benzyl]oxy]benzaldehyde
0.0064
5-bromo-2-(5-[(E)-[1-(3,4-dichlorophenyl)-3,5-dioxopyrazolidin-4-ylidene]methyl]furan-2-yl)benzoic acid
-
pH and temperature not specified in the publication
0.00219
5-bromo-2-(5-[[1-(3,4-dichlorophenyl)-3,5-dioxo-4-pyrazolidinylidene]methyl]-2-furyl)benzoic acid
0.0024 - 0.0032
6-cyclohexamidomanzamine A
0.012 - 0.021
6-deoxymanzamine X
0.011 - 0.015
8-hydroxymanzamine A
0.000005
asxe1
-
pH and temperature not specified in the publication
0.0049
disodium 7-amino-3-[(E)-(5-hydroxy-7-sulfonatonaphthalen-2-yl)diazenyl]naphthalene-2-sulfonate
-
pH and temperature not specified in the publication
0.12 - 0.151
manzamine A
0.058 - 0.063
manzamine E
0.022 - 0.04
manzamine F
4.95
shikimate
at pH 7.5 and 25°C
0.041 - 0.71
sodium (3R,4R,5R)-3,4-dihydroxy-5-((perfluorophenyl)methoxy)-cyclohex-1-ene-1-carboxylate
0.00046 - 0.01
sodium (3R,4R,5R)-3,4-dihydroxy-5-(3-nitrobenzyloxy)cyclohex-1-ene-1-carboxylate
0.455 - 2
sodium (3R,4S,5R)-3,4-dihydroxy-5-[[(1H-indol-5-yl)methyl]amino]cyclohex-1-ene-1-carboxylate
0.181 - 2
sodium (3R,4S,5R)-3,4-dihydroxy-5-[[(naphthalen-2-yl)methyl]amino]cyclohex-1-ene-1-carboxylate
0.0003 - 0.048
sodium (3R,4S,5R)-5-di(naphth-2-yl)methylamino-3,4-dihydroxycyclohex-1-eno-1-carboxylate
0.0052 - 0.024
sodium (3R,4S,5R)-5-[bis[(1-benzothiophen-5-yl)methyl]amino]-3,4-dihydroxycyclohex-1-ene-1-carboxylate
0.415 - 0.535
sodium (3S,4R,5R)-3-amino-5-(benzo[b]thiophen-5-yl)-methoxy-4-hydroxycyclohex-1-ene-carboxylate
0.8 - 2
sodium (3S,4S,5R)-3-amino-4-hydroxy-5-(naphth-2-yl)-metoxycyclohex-1-ene-carboxylate