2.7.1.67: 1-phosphatidylinositol 4-kinase

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For detailed information about 1-phosphatidylinositol 4-kinase, go to the full flat file.

Reaction

Synonyms

1-phosphatidyl-1D-myo-inositol 4-phosphotransferase, 56 kDa type II PtdIns 4-kinase, alpha type II PI 4-kinase, AtPI4KIIIalpha1, AtPI4KIIIbeta1, AtPI4KIIIbeta2, beta type II PI 4-kinase, beta-type phosphatidylinositol 4-kinase, kinase, phosphatidylinositol (phosphorylating), Lsb6, Lsb6p, phosphatidyl-inositol 4-kinase type IIIalpha, phosphatidylinositol 4 kinase, phosphatidylinositol 4 kinase IIIbeta, phosphatidylinositol 4-kinase, phosphatidylinositol 4-kinase beta, phosphatidylinositol 4-kinase beta1, phosphatidylinositol 4-kinase IIalpha, phosphatidylinositol 4-kinase IIbeta, phosphatidylinositol 4-kinase III alpha, phosphatidylinositol 4-kinase IIIalpha, phosphatidylinositol 4-kinase IIIbeta, phosphatidylinositol 4-kinase IIIbeta,, phosphatidylinositol 4-kinase type 2-alpha, phosphatidylinositol 4-kinase type II, phosphatidylinositol 4-kinase type II alpha, phosphatidylinositol 4-kinase type IIalpha, phosphatidylinositol 4-kinase type IIbeta, phosphatidylinositol 4-kinase type-III alpha, phosphatidylinositol kinase, phosphatidylinositol-4-kinase, phosphatidylinositol-4-kinase IIalpha, phosphatidylinositol-4-kinase III beta, phosphatidylinositol-4-kinase type II alpha, phosphatidylinositol-4-kinase type IIalpha, PI 4-kinase, PI 4-kinase type IIalpha, PI kinase, PI-4 kinase, PI4-kinase, PI4K, PI4K beta, PI4K IIalpha, PI4K IIbeta, PI4K IIIbeta, PI4K2, PI4K230, PI4K2A, PI4K55, PI4K92, PI4KA, PI4KB, PI4Kbeta, PI4Kbeta1, PI4Kgamma3, PI4Kgamma5, PI4KII, PI4KIIalpha, PI4KIIbeta, PI4KIII-beta, PI4KIIIalpha, PI4KIIIbeta, Pik1, Pik1p, PIK230, Pik2p, Pik4ca, PIK4IIalpha, PIK4IIbeta, PIK4IIIalpha, PIK4IIIbeta, PIK55, PIKCB, PtdIns 4-kinase, PtdIns 4-kinase beta, PtdIns4KIIalpha, Stt4p, type II phosphatidylinositol 4-kinase, type II phosphatidylinositol kinase, type II phosphoinositide 4-kinase, type II PI 4-kinase enzyme, type II PI4Kalpha, type II PtdIns 4-kinase, type IIalpha phosphatidylinositol 4-kinase, type III alpha phosphatidylinositol 4-kinase, type III phosphatidylinositol 4-kinase alpha, type III phosphatidylinositol 4-kinase beta, type III PI 4-kinase beta, type III PI4K, type III PI4Kbeta, type-II PI4K, type-III phosphatidylinositol 4-kinase beta1, type-III phosphatidylinositol 4-kinase beta2, type-III PI4K

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.67 1-phosphatidylinositol 4-kinase

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Results	in table
70	Activating Compound
10362	AA Sequence
3	Application
1	CAS Registry Number
33	Cloned(Commentary)
31	Cofactor
5	Crystallization (Commentary)
330	Disease/ Diagnostics
3	Expression
63	General Information
1	General Stability
160	IC50 Value
470	Inhibitors
42	Ki Value [mM]
72	KM Value [mM]
166	Localization
74	Metals/Ions
49	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
155	Organism
4	Pathway
49	PDB ID
27	pH Optimum
14	pH Range
1	pH Stability
1	pI Value
10	Posttranslational Modification
26	Protein Variants
47	Purification (Commentary)
5	Reaction
1	Reaction Type
144	Reference
1	Renatured (Commentary)
131	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
164	Substrates and Products (Substrate)
29	Subunits
242	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
2	Temperature Range [°C]
9	Temperature Stability [°C]
4	Turnover Number [1/s]

pH Range

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pH Range on EC 2.7.1.67 - 1-phosphatidylinositol 4-kinase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 8

Bos taurus

-

pH 5.0: about 40% of maximal activity, pH 8.0: about 50% of maximal activity

641787

5.3 - 9

Rattus norvegicus

-

pH 5.3: about 80% of maximal activity, pH 8.6: about 60% of maximal activity

641790

5.5 - 8

Ovis aries

-

rapid decrease of activity above pH 8.0 and below pH 5.5

641798

5.5 - 9

Homo sapiens

-

pH 5.5: 60% of maximal activity for mPIK-I and 45% of maximal activity of mPIK-III, pH 8.5-9.0: pH-optimum for enzyme form mPIK-I and mPIK-III

641801

6 - 8.5

Oryctolagus cuniculus

-

pH 7.5: about 75% of maximal activity, pH 10.5: about 40% of maximal activity, PI kinase III

641774

6 - 9

2 entries

6 - 9.5

Saccharomyces cerevisiae

-

pH 6.0: about 75% of maximal activity, pH 9.5: about 60% of maximal activity

641785

6.3 - 8.7

Rattus norvegicus

-

pH 6.3: about 50% of maximal activity, pH 8.7: about 80% of maximal activity

641769

6.5 - 8.5

Daucus carota

-

pH 6.5: about 40% of maximal activity, pH 8.0-8.5: optimium

641811

7 - 8

Spinacia oleracea

-

pH 7.0: about 70% of maximal activity, pH 8.0: about 45% of maximal activity

641815

7 - 8.5

Spinacia oleracea

-

pH 7.0: about 50% of maximal activity, pH 8.5: about 40% of maximal activity, enzyme form QII

641815

7.3 - 9

Rattus norvegicus

-

pH 7.3: about 75% of maximal activity, pH 9.0: about 95% of maximal activity

641773

7.5 - 10.5

Oryctolagus cuniculus

-

pH 7.5: about 50% of maximal activity, pH 10.5: about 65% of maximal activity, PI kinase I

641774

6 - 9

Homo sapiens

-

activity of cPIK-I and cPIK-III is almost undetectable at pH 6.0, pH 9.0: about 80% of maximal activity

641801

6 - 9

Saccharomyces cerevisiae

-

active from pH 6.0 to pH 9.0 with Tris maleate buffer

641783